DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Amy-d and AMY1B

DIOPT Version :9

Sequence 1:	NP_523768.1	Gene:	Amy-d / 36932	FlyBaseID:	FBgn0000078	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001008219.1	Gene:	AMY1B / 277	HGNCID:	475	Length:	511	Species:	Homo sapiens

Alignment Length:	500	Identity:	270/500 - (54%)
Similarity:	337/500 - (67%)	Gaps:	26/500 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 AQFDTNYASGRSGMVHLFEWKWDDIAAECENFLGPNGYAGVQVSPVNENAV--KDSRPWWERYQP 80
            ||:.:|...||:.:||||||:|.|||.|||.:|.|.|:.||||||.|||..  ...|||||||||
Human    15 AQYSSNTQQGRTSIVHLFEWRWVDIALECERYLAPKGFGGVQVSPPNENVAIHNPFRPWWERYQP 79

  Fly    81 ISYKLETRSGNEEQFASMVKRCNAVGVRTYVDVVFNHM---AADGGTYGTGGSTASPSSKSYPGV 142
            :||||.||||||::|.:||.|||.||||.|||.|.|||   |...||..|.||..:|.|:.:|.|
Human    80 VSYKLCTRSGNEDEFRNMVTRCNNVGVRIYVDAVINHMCGNAVSAGTSSTCGSYFNPGSRDFPAV 144

  Fly   143 PYSSLDFNP-TCA-----ISNYNDANEVRNCELVGLRDLNQGNSYVQDKVVEFLDHLIDLGVAGF 201
            |||..|||. .|.     |.|||||.:||:|.|.||.||..|..||:.|:.|:::||||:|||||
Human   145 PYSGWDFNDGKCKTGSGDIENYNDATQVRDCRLSGLLDLALGKDYVRSKIAEYMNHLIDIGVAGF 209

  Fly   202 RVDAAKHMWPADLAVIYGRLKNLNTDHGFASGSKAYIVQEVIDMGGEAISKSEYTGLGAITEFRH 266
            |:||:|||||.|:..|..:|.|||: :.|..|||.:|.|||||:|||.|..|:|.|.|.:|||::
Human   210 RIDASKHMWPGDIKAILDKLHNLNS-NWFPEGSKPFIYQEVIDLGGEPIKSSDYFGNGRVTEFKY 273

  Fly   267 SDSIGKVFR--GKDQLQYLTNWGTAWGFAASDRSLVFVDNHDNQRGHGAGGADVLTYKVPKQYKM 329
            ...:|.|.|  ..:::.||.|||..|||..|||:||||||||||||||||||.:||:...:.|||
Human   274 GAKLGTVIRKWNGEKMSYLKNWGEGWGFMPSDRALVFVDNHDNQRGHGAGGASILTFWDARLYKM 338

  Fly   330 ASAFMLAHPFGTPRVMSSFSF-------TDTDQ--GPPTTDGHNIASPI-FNSDNSCSGGWVCEH 384
            |..||||||:|..|||||:.:       .|.:.  |||..:|  :...: .|.|.:|...|||||
Human   339 AVGFMLAHPYGFTRVMSSYRWPRYFENGKDVNDWVGPPNDNG--VTKEVTINPDTTCGNDWVCEH 401

  Fly   385 RWRQIYNMVAFRNAVGLDEIQNWWDSGSNQISFSRGSRGFVAFNNDNYDLNSSLQTGLPAGTYCD 449
            |||||.|||.|||.|......||:|:||||::|.||:|||:.||||::..:.:||||||||||||
Human   402 RWRQIRNMVNFRNVVDGQPFTNWYDNGSNQVAFGRGNRGFIVFNNDDWTFSLTLQTGLPAGTYCD 466

  Fly   450 VISGSKSGSSCTGKTVTVGSDGRASIYIGSSEDDGVLAIHVNAKL 494
            ||||.|...:|||..:.|..||:|...|.:|.:|..:|||..:||
Human   467 VISGDKINGNCTGIKIYVSDDGKAHFSISNSAEDPFIAIHAESKL 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Amy-d	NP_523768.1	AmyAc_bac_euk_AmyA	28..399	CDD:200456	216/393 (55%)
		Alpha-amylase	54..342	CDD:278554	171/300 (57%)
		Aamy_C	405..493	CDD:214749	47/87 (54%)
AMY1B	NP_001008219.1	AmyAc_bac_euk_AmyA	25..416	CDD:200456	216/393 (55%)
AMY1B	NP_001008219.1	Aamy_C	422..510	CDD:214749	47/87 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	268	1.000	Domainoid score	I1866
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	550	1.000	Inparanoid score	I1140
Isobase	1	0.950	-	0	Normalized mean entropy	S3326
OMA	1	1.010	-	-		QHG53143
OrthoDB	1	1.010	-	-		D231864at33208
OrthoFinder	1	1.000	-	-		FOG0000926
OrthoInspector	1	1.000	-	-		mtm8522
orthoMCL	1	0.900	-	-		OOG6_103366
Panther	1	1.100	-	-	O	PTHR43447
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X338
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790