DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Amy-d and amy2a

DIOPT Version :9

Sequence 1:	NP_523768.1	Gene:	Amy-d / 36932	FlyBaseID:	FBgn0000078	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_002938902.1	Gene:	amy2a / 100125163	XenbaseID:	XB-GENE-968629	Length:	511	Species:	Xenopus tropicalis

Alignment Length:	513	Identity:	282/513 - (54%)
Similarity:	360/513 - (70%)	Gaps:	26/513 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KSIVCLSLLAVANAQFDTNYASGRSGMVHLFEWKWDDIAAECENFLGPNGYAGVQVSPVNENAVK 69
            |.::.|..:.:.:||::.|..|||:.:||||||:|||||||||.:|||||:.|||:||.||:.:.
Frog     2 KVLLLLVAIGLCSAQYNPNTQSGRTSIVHLFEWRWDDIAAECERYLGPNGFGGVQISPPNEHIIV 66

  Fly    70 DS--RPWWERYQPISYKLETRSGNEEQFASMVKRCNAVGVRTYVDVVFNHMAADG---GTYGTGG 129
            .:  ||||||||||||||.:|||||:||..||.|||.|||..|||.|.|||...|   ||:.:.|
Frog    67 TNPYRPWWERYQPISYKLCSRSGNEQQFRDMVTRCNNVGVYIYVDAVINHMCGSGGGAGTHSSCG 131

  Fly   130 STASPSSKSYPGVPYSSLDFNP-TC-----AISNYNDANEVRNCELVGLRDLNQGNSYVQDKVVE 188
            |..:..|:.:| |||||.|||. .|     .|.||:|||:||:|.||||.||.....||:.|:.|
Frog   132 SYFNAGSREFP-VPYSSWDFNDGKCRTGSGEIENYSDANQVRDCRLVGLLDLALEKDYVRGKIAE 195

  Fly   189 FLDHLIDLGVAGFRVDAAKHMWPADLAVIYGRLKNLNTDHGFASGSKAYIVQEVIDMGGEAISKS 253
            |:::||::||||||:||||||||.||..|..||.|||| ..|.:|::.:|.|||||:||||||.:
Frog   196 FMNNLINIGVAGFRLDAAKHMWPGDLKAISERLNNLNT-KWFPAGARPFIFQEVIDLGGEAISVN 259

  Fly   254 EYTGLGAITEFRHSDSIGKVFR--GKDQLQYLTNWGTAWGFAASDRSLVFVDNHDNQRGHGAGGA 316
            ||.|:|.:|||::...:|.|.|  ..::|.||.|||..|||..:||:||||||||||||||||||
Frog   260 EYYGIGRVTEFKYGAKLGTVIRKWNGEKLSYLRNWGEGWGFMPNDRALVFVDNHDNQRGHGAGGA 324

  Fly   317 DVLTYKVPKQYKMASAFMLAHPFGTPRVMSSFSFT-----DTDQ----GPPT-TDGHNIASPIFN 371
            .:||:...:.|||...||||||:|..||||||.::     ..||    |||: :||...:.|| |
Frog   325 SILTFWDARLYKMGVGFMLAHPYGFTRVMSSFRWSRNIVNGKDQNDWIGPPSNSDGSTKSVPI-N 388

  Fly   372 SDNSCSGGWVCEHRWRQIYNMVAFRNAVGLDEIQNWWDSGSNQISFSRGSRGFVAFNNDNYDLNS 436
            .|::|...||||||||||.|||.|||........||||:||||::|.||::||:.||||::.|:.
Frog   389 PDSTCGDNWVCEHRWRQIKNMVTFRNVADGQPFSNWWDNGSNQVAFGRGNKGFIIFNNDDWQLDV 453

  Fly   437 SLQTGLPAGTYCDVISGSKSGSSCTGKTVTVGSDGRASIYIGSSEDDGVLAIHVNAKL 494
            :|.||||:|||||||||.|.||.|||:.:.|..:|.|...|.::::|...||||||||
Frog   454 TLNTGLPSGTYCDVISGQKEGSRCTGRQINVDGNGYAKFQISNNDEDPFAAIHVNAKL 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Amy-d	NP_523768.1	AmyAc_bac_euk_AmyA	28..399	CDD:200456	224/393 (57%)
		Alpha-amylase	54..342	CDD:278554	170/300 (57%)
		Aamy_C	405..493	CDD:214749	48/87 (55%)
amy2a	XP_002938902.1	AmyAc_bac_euk_AmyA	25..416	CDD:200456	224/393 (57%)
amy2a	XP_002938902.1	Aamy_C	423..510	CDD:214749	48/86 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	264	1.000	Domainoid score	I1877
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H134663
Inparanoid	1	1.050	567	1.000	Inparanoid score	I1058
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D231864at33208
OrthoFinder	1	1.000	-	-		FOG0000926
OrthoInspector	1	1.000	-	-		mtm9418
Panther	1	1.100	-	-	LDO	PTHR43447
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4468
SonicParanoid	1	1.000	-	-		X338
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190