DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn53F and SERPINH1

DIOPT Version :9

Sequence 1:	NP_001036553.1	Gene:	Spn53F / 36931	FlyBaseID:	FBgn0034195	Length:	379	Species:	Drosophila melanogaster
Sequence 2:	NP_001193943.1	Gene:	SERPINH1 / 871	HGNCID:	1546	Length:	418	Species:	Homo sapiens

Alignment Length:	377	Identity:	77/377 - (20%)
Similarity:	152/377 - (40%)	Gaps:	30/377 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 AQKNSQLPDELYAAIVNSFSNRNIMFSTEMIRSSMLFIYVGVEEDESEQIRKAMHYRGTHLSEYK 80
            |::::.|...||.|:....:..||:.|..::.||:..:.:|.:...:.|.:..       ||..:
Human    44 AERSAGLAFSLYQAMAKDQAVENILVSPVVVASSLGLVSLGGKATTASQAKAV-------LSAEQ 101

  Fly    81 PKTQKIFA------MSVKKAPVAKSLT-----RFYVRQNMKMSTEY-RVFMRHTEGRARNIAF-- 131
            .:.:::.|      .|:..: .|:::|     |.|...::..:.:: |...:|.......|.|
Human   102 LRDEEVHAGLGELLRSLSNS-TARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRD 165

  Fly   132 AREQLDEVNTFYSHEMGEQIGQVVKESWWKPNSQGLLVNAIFFNLSWERTFNPEATYPREFRVNA 196
            .|..|..:|.:.:.....::.:|.|:.  :.....|||||:||...|:..|:.:....|.|.|..
Human   166 KRSALQSINEWAAQTTDGKLPEVTKDV--ERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTR 228

  Fly   197 TKSVMIPMMHEDSKFAFGILGNLKATAVLVPFSHGDLRMLLIKPDQPDGLAALQMKLQAMNILSV 261
            :.:|.:.|||....:.:......|...|.:|.:|....::::.|...:.|..|:..|....:...
Human   229 SYTVGVMMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIW 293

  Fly   262 ARNLTMMDVFVGIPKFKIHSDLELSPAFEKMGIKDIFKPSKSFSTLLHRNTNFRIDGVIHVVTFE 326
            ...:....|.:.:||..:....:|......:|:.:....:|:..:.:....:..:..|.|...||
Human   294 MGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFE 358

  Fly   327 FQEQGIGTPSTDVGNGSLTHTFNGVKYFLATHPFAFYIID--NTSIYFAGHV 376
            ....|........|...|    ...|.|.|.|||.|.:.|  :.|:.|.|.:
Human   359 LDTDGNPFDQDIYGREEL----RSPKLFYADHPFIFLVRDTQSGSLLFIGRL 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn53F	NP_001036553.1	SERPIN	25..376	CDD:238101	75/366 (20%)
SERPINH1	NP_001193943.1	serpinH1_CBP1	36..417	CDD:381003	77/377 (20%)
SERPINH1	NP_001193943.1	Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	415..418
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920