DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn53F and Serpind1

DIOPT Version :9

Sequence 1:	NP_001036553.1	Gene:	Spn53F / 36931	FlyBaseID:	FBgn0034195	Length:	379	Species:	Drosophila melanogaster
Sequence 2:	NP_077358.1	Gene:	Serpind1 / 79224	RGDID:	619854	Length:	479	Species:	Rattus norvegicus

Alignment Length:	403	Identity:	85/403 - (21%)
Similarity:	168/403 - (41%)	Gaps:	48/403 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLLILLGISRYRAQK--NSQLPDELYAAIVN-SFSNRNIMFSTEMIRSSMLFIYVGVEEDESEQI 65
            :|.:..|.||.:...  |::....||..:.: :.|:.||..:...|.::|..|.:|:..:..|::
  Rat    93 ILQLFQGKSRIQRLNILNAKFAFNLYRVLKDQATSSDNIFIAPVGISTAMGMISLGLRGETHEEV 157

  Fly    66 RKAMHYRG-----------THLSEYKPKTQKIFAMSVKKAPVAKSLTRFYVRQNMKMSTEYRVFM 119
            ...:|::.           |..:.::..|.::|..:.  ....:|:...|:::...:..:::..|
  Rat   158 HSVLHFKDFVNASSKYEVTTIHNLFRKLTHRLFRRNF--GYTLQSVNDLYIQKQFPIREDFKAAM 220

  Fly   120 RHTEGRARNIAFAREQ---------LDEVNTFYSHEMGEQIGQVVKESWWKPNS--QGLLVNAIF 173
                   |...||..|         :.:.|   ||.:....| ::||:....:|  |.:::|.|:
  Rat   221 -------REFYFAEAQEADFSDPAFISKAN---SHILKLTKG-LIKEALENTDSATQMMILNCIY 274

  Fly   174 FNLSWERTFNPEATYPREFRVNATKSVMIPMMHEDSKFAFGILGNLKATAVLVPFSHGDLRMLLI 238
            |..:|...|..|.|:...||:|..:.|.:.||.....|.......|....:.:.:. |.:.||::
  Rat   275 FKGAWMNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYV-GGISMLIV 338

  Fly   239 KPDQPDGLAALQMKLQAMNILSVARNLTMMDVFVGIPKFKIHSDLELSPAFEKMGIKDIFKPSKS 303
            .|.:..|:..|:.:|....:....:::|.....|.:||||:..:..|....:.|||..:|..:.:
  Rat   339 IPRKLSGMKTLEAQLTPQVVERWQKSMTNRTREVLLPKFKLEKNYNLVEVLKSMGITKLFNKNGN 403

  Fly   304 FSTLLHRNTNFRIDGVIHVVTFEFQEQGIGTPS-TDVGNGSLTHTFNGVKYFLATHPFAFYIIDN 367
            .|.:  .:....||...|..|....|:|....: |.||...|:....    |....||.|.:.::
  Rat   404 MSGI--SDQRIIIDLFKHQSTITVNEEGTQAAAVTTVGFMPLSTQVR----FTVDRPFLFLVYEH 462

  Fly   368 --TSIYFAGHVTS 378
              :.:.|.|.|.:
  Rat   463 RTSCLLFMGRVAN 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn53F	NP_001036553.1	SERPIN	25..376	CDD:238101	79/376 (21%)
Serpind1	NP_077358.1	HCII	44..477	CDD:239002	85/403 (21%)
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	55..79
		Glycosaminoglycan-binding site. /evidence=ECO:0000250	172..192		3/19 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110