DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn53F and SERPINB4

DIOPT Version :9

Sequence 1:	NP_001036553.1	Gene:	Spn53F / 36931	FlyBaseID:	FBgn0034195	Length:	379	Species:	Drosophila melanogaster
Sequence 2:	NP_002965.1	Gene:	SERPINB4 / 6318	HGNCID:	10570	Length:	390	Species:	Homo sapiens

Alignment Length:	407	Identity:	99/407 - (24%)
Similarity:	169/407 - (41%)	Gaps:	66/407 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 AQKNSQLPDELYAAIVNSFSNRNIMFSTEMIRSSMLFIYVGVEEDESEQIRKAMHY-RGTHLSEY 79
            ::.|::...:|:.....|..| ||.:|...|.|::..:.:|.:::.::||.|.:|: :.|..:..
Human     5 SEANTKFMFDLFQQFRKSKEN-NIFYSPISITSALGMVLLGAKDNTAQQISKVLHFDQVTENTTE 68

  Fly    80 KPKTQKIFAMSVKKAPVAKSLTRFYVRQNMKMSTEYRVFMRHTEGRARNIAFAREQLDEVNTFYS 144
            |..|..:...........|.||.|     .|.:..|.:.:.:.....:...|.:|.||.:..||.
Human    69 KAATYHVDRSGNVHHQFQKLLTEF-----NKSTDAYELKIANKLFGEKTYQFLQEYLDAIKKFYQ 128

  Fly   145 HEM-GEQIGQVVKESWWKPNS---------------QG--------LLVNAIFFNLSWERTFNPE 185
            ..: ........:||..|.||               .|        :|||||:|...||..|..|
Human   129 TSVESTDFANAPEESRKKINSWVESQTNEKIKNLFPDGTIGNDTTLVLVNAIYFKGQWENKFKKE 193

  Fly   186 ATYPREFRVNATKSVMIPMMHEDSKFAFGILGNLKATAVLVPFSHGDLRMLLIKPDQPDGLAALQ 250
            .|...:|..|......:.||.:.:.|.|.:|.:::|..:.:|:...||.|:::.|::.|||..|:
Human   194 NTKEEKFWPNKNTYKSVQMMRQYNSFNFALLEDVQAKVLEIPYKGKDLSMIVLLPNEIDGLQKLE 258

  Fly   251 MKLQAMNIL--SVARNLTMMDVFVGIPKFKIHSDLELSPAFEKMGIKDIFKPSKSFS--TLLHRN 311
            .||.|..::  :..:|:....|.:.:|:||:....:|......||:.:||......|  |..|
Human   259 EKLTAEKLMEWTSLQNMRETCVDLHLPRFKMEESYDLKDTLRTMGMVNIFNGDADLSGMTWSH-- 321

  Fly   312 TNFRIDGVIHVVTFEFQEQGI-------------GTPSTDVGNGSLTHTFNGVKYFLATHPFAFY 363
             ...:..|:|....|..|:|:             .:|||:             :.|...|||.|:
Human   322 -GLSVSKVLHKAFVEVTEEGVEAAAATAVVVVELSSPSTN-------------EEFCCNHPFLFF 372

  Fly   364 IIDN--TSIYFAGHVTS 378
            |..|  .||.|.|..:|
Human   373 IRQNKTNSILFYGRFSS 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn53F	NP_001036553.1	SERPIN	25..376	CDD:238101	97/394 (25%)
SERPINB4	NP_002965.1	SERPIN	4..390	CDD:320777	99/407 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.930