DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn53F and SERPINI1

DIOPT Version :9

Sequence 1:	NP_001036553.1	Gene:	Spn53F / 36931	FlyBaseID:	FBgn0034195	Length:	379	Species:	Drosophila melanogaster
Sequence 2:	NP_001116224.1	Gene:	SERPINI1 / 5274	HGNCID:	8943	Length:	410	Species:	Homo sapiens

Alignment Length:	403	Identity:	92/403 - (22%)
Similarity:	173/403 - (42%)	Gaps:	48/403 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLILLGISRYRAQKNSQLPDELYAAIVNSFSNR--------NIMFSTEMIRSSMLFIYVGVEEDE 61
            ||:|..::     ..:..|:|..|.:..:..||        ||:||...|..:|..:.:|.:...
Human     9 LLVLQSMA-----TGATFPEEAIADLSVNMYNRLRATGEDENILFSPLSIALAMGMMELGAQGST 68

  Fly    62 SEQIRKAMHY----RGTHLSEYKPKTQKIFAMSVKKAPVAKSLTRFYVRQNMKMSTEYRVFMR-- 120
            .::||.:|.|    .|...|..|..:..:.|.  :...|.|.....:|:....::.|:...|:
Human    69 QKEIRHSMGYDSLKNGEEFSFLKEFSNMVTAK--ESQYVMKIANSLFVQNGFHVNEEFLQMMKKY 131

  Fly   121 ------HTEGRARNIAFAREQLDEVNTFYSHEMGEQIGQVVKESWWKPNSQGLLVNAIFFNLSWE 179
                  |.: .::|:|.|    :.:|.:..:.....:..:|....:...:...|:||::|..:|:
Human   132 FNAAVNHVD-FSQNVAVA----NYINKWVENNTNNLVKDLVSPRDFDAATYLALINAVYFKGNWK 191

  Fly   180 RTFNPEATYPREFRVNATKSVMIPMMHEDSKFAFGIL--GNLKATAVL----VPFSHGDLRMLLI 238
            ..|.||.|....|..:....|.||||::..:|.:|..  |:.:|..:.    :|:...::.|:|:
Human   192 SQFRPENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLV 256

  Fly   239 KPDQPDGLAALQMKLQAMNILSVARNLTMMDVFVGIPKFKIHSDLELSPAFEKMGIKDIFKPSKS 303
            ...|...||.|:..::|..:...|.::....|.|.:|:|.:..:::|....:.:||.:||....:
Human   257 LSRQEVPLATLEPLVKAQLVEEWANSVKKQKVEVYLPRFTVEQEIDLKDVLKALGITEIFIKDAN 321

  Fly   304 FSTLLHRNTNFRIDGVIHVVTFEFQEQGIGTPSTDVGNGSLTHTFNGVKY--FLATHPFAFYIID 366
            . |.|..|....:...||....|..|:|....:.   :|.:..:...|.|  .:..||| |::|.
Human   322 L-TGLSDNKEIFLSKAIHKSFLEVNEEGSEAAAV---SGMIAISRMAVLYPQVIVDHPF-FFLIR 381

  Fly   367 NT---SIYFAGHV 376
            |.   :|.|.|.|
Human   382 NRRTGTILFMGRV 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn53F	NP_001036553.1	SERPIN	25..376	CDD:238101	87/381 (23%)
SERPINI1	NP_001116224.1	neuroserpin	23..410	CDD:239003	88/384 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBFJ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.930