Protein Alignment Spn53F and SERPINB10

DIOPT Version :10

• Sequence 1: NP_001036553.1
• Gene: Spn53F / 36931
• FlyBaseID: FBgn0034195
• Length: 379
• Species: Drosophila melanogaster
• Sequence 2: NP_005015.1
• Gene: SERPINB10 / 5273
• HGNCID: 8942
• Length: 397
• Species: Homo sapiens
• Alignment Length: 393
• Identity: 92/393 - (23%)
• Similarity: 173/393 - (44%)
• Gaps: 39/393 - (9%)

  Fly    20 SQLPDELYAAIVNSFSNRNIMFSTEMIRSSMLFIYVGVEEDESEQIRKAMHYRGTHLSEYKPKTQ 84
            :|...||...:..|...:||.||:..|.:|:..:|:|.:...:.|:.:.:.:......:..|:::
Human     9 NQFALELSKKLAESAQGKNIFFSSWSISTSLTIVYLGAKGTTAAQMAQVLQFNRDQGVKCDPESE 73

  Fly    85 KIFAM--SVKKAPVAKSLTRFYVRQNMKMSTEYRVFMRHTEGRARNIAFAREQLDEVNTFYSHE- 146
            |...|  ::..:....|..:..:.:.:|.:.:|.:...:.....:..||..:.|:::.|::..|
Human    74 KKRKMEFNLSNSEEIHSDFQTLISEILKPNDDYLLKTANAIYGEKTYAFHNKYLEDMKTYFGAEP 138

  Fly   147 ----MGEQIGQVVKE--SWWKPNSQG-----------------LLVNAIFFNLSWERTFNPEATY 188
                ..|...|:.|:  ||.:..::|                 :||||::|...||..|..:.|.
Human   139 QPVNFVEASDQIRKDINSWVERQTEGKIQNLLPDDSVDSTTRMILVNALYFKGIWEHQFLVQNTT 203

  Fly   189 PREFRVNATKSVMIPMMHEDSKFAFGILGNLKATAVLVPFSHGDLRMLLIKPDQPDGLAALQMKL 253
            .:.||:|.|.|..:.||....|.....:...||..:.:.:...||.:|::.|:..:||..|:..:
Human   204 EKPFRINETTSKPVQMMFMKKKLHIFHIEKPKAVGLQLYYKSRDLSLLILLPEDINGLEQLEKAI 268

  Fly   254 --QAMNILSVARNLTMMDVFVGIPKFKIHSDLELSPAFEKMGIKDIFKPSKSFSTLLHRNTNFRI 316
              :.:|..:.|..:.:.:|.:.:||||:....:|......||:.|.|..||:..:.:....|..:
Human   269 TYEKLNEWTSADMMELYEVQLHLPKFKLEDSYDLKSTLSSMGMSDAFSQSKADFSGMSSARNLFL 333

  Fly   317 DGVIHVVTFEFQEQGIGTPSTDVGNGSLTHTFNGVKY----FLATHPFAFYIIDN--TSIYFAGH 375
            ..|.|....|..|||     |:...||.:.....::.    |.|.|||.|:|..|  .:|.|.|.
Human   334 SNVFHKAFVEINEQG-----TEAAAGSGSEIDIRIRVPSIEFNANHPFLFFIRHNKTNTILFYGR 393

  Fly   376 VTS 378
            :.|
Human   394 LCS 396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn53F	NP_001036553.1	serpin42Dd-like_insects	20..379	CDD:381070	92/393 (23%)
SERPINB10	NP_005015.1	serpinB10_bomapin	1..397	CDD:381035	92/393 (23%)
		Nuclear localization signal	74..77		1/2 (50%)