DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn53F and SERPINB8

DIOPT Version :9

Sequence 1:	NP_001036553.1	Gene:	Spn53F / 36931	FlyBaseID:	FBgn0034195	Length:	379	Species:	Drosophila melanogaster
Sequence 2:	NP_001353127.1	Gene:	SERPINB8 / 5271	HGNCID:	8952	Length:	374	Species:	Homo sapiens

Alignment Length:	382	Identity:	84/382 - (21%)
Similarity:	166/382 - (43%)	Gaps:	34/382 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 QKNSQLPDELYAAIVNSFSNRNIMFSTEMIRSSMLFIYVGVEEDESEQIRKAM-------HYRG- 73
            :.|......|:..:....::||:.||...|.|::..:::|.:...:.|:.:|:       .:||
Human     6 EANGTFAISLFKILGEEDNSRNVFFSPMSISSALAMVFMGAKGSTAAQMSQALCLYKDGDIHRGF 70

  Fly    74 -THLSEY-KPKTQKIFAMSVKKAPVAKSLTRFYVRQNMKMSTEYRVF-MRHTEGRARNIAFAREQ 135
             :.|||. :..||.:.          ::..|.:..:......:::.: .:..:.....::|| |.
Human    71 QSLLSEVNRTGTQYLL----------RTANRLFGEKTCDFLPDFKEYCQKFYQAELEELSFA-ED 124

  Fly   136 LDE----VNTFYSHEMGEQIGQVVKESWWKPNSQGLLVNAIFFNLSWERTFNPEATYPREFRVNA 196
            .:|    :|.:.:.:...:|.:|:......|.::.:|||||:|...|...|:.:.|....|:.|.
Human   125 TEECRKHINDWVAEKTEGKISEVLDAGTVDPLTKLVLVNAIYFKGKWNEQFDRKYTRGMLFKTNE 189

  Fly   197 TKSVMIPMMHEDSKFAFGILGNLKATAVLVPFSHGDLRMLLIKPDQPDGLAALQMKL--QAMNIL 259
            .|.. :.||.:::||..|....:....:.:|:...:|.|:::.||....||.::..|  :.....
Human   190 EKKT-VQMMFKEAKFKMGYADEVHTQVLELPYVEEELSMVILLPDDNTDLAVVEKALTYEKFKAW 253

  Fly   260 SVARNLTMMDVFVGIPKFKIHSDLELSPAFEKMGIKDIFKPSKSFSTLLHRNTNFRIDGVIHVVT 324
            :.:..||...|.|.:|:.|:....:|.|...::|:.|.|..:|:..:.:....|..:..|.|...
Human   254 TNSEKLTKSKVQVFLPRLKLEESYDLEPFLRRLGMIDAFDEAKADFSGMSTEKNVPLSKVAHKCF 318

  Fly   325 FEFQEQGI-GTPSTDVGNGSLTHTFNGVKYFLATHPFAFYIIDNTS--IYFAGHVTS 378
            .|..|:|. ...:|.|...|......  ..|.|.|||.|:|..:.:  |.|.|..:|
Human   319 VEVNEEGTEAAAATAVVRNSRCSRME--PRFCADHPFLFFIRHHKTNCILFCGRFSS 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn53F	NP_001036553.1	SERPIN	25..376	CDD:238101	82/370 (22%)
SERPINB8	NP_001353127.1	SERPIN	4..374	CDD:320777	84/382 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.930