DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn53F and SERPINE2

DIOPT Version :9

Sequence 1:	NP_001036553.1	Gene:	Spn53F / 36931	FlyBaseID:	FBgn0034195	Length:	379	Species:	Drosophila melanogaster
Sequence 2:	XP_005246698.1	Gene:	SERPINE2 / 5270	HGNCID:	8951	Length:	410	Species:	Homo sapiens

Alignment Length:	373	Identity:	82/373 - (21%)
Similarity:	154/373 - (41%)	Gaps:	35/373 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ELYAAIVNSFSNRNIMFSTEMIRSSMLFIYVGVEEDESEQIRKAMHYRGTHLSEYKPKTQKIFAM 89
            :::..||.|..:.||:.|...|.|.:..:.:|.:....:|:...|.|....:.:...|..|.. :
Human    49 QVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKKINKAI-V 112

  Fly    90 SVKKAPVAKSLTRFYVRQNMKMSTEY-----RVFMRHTEGRARNIAF--AREQLDEVNTFYSHEM 147
            |.|...:.......:|:...::...:     .||    :...||:.|  .....|.:|.:..:|.
Human   113 SKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVF----QCEVRNVNFEDPASACDSINAWVKNET 173

  Fly   148 GEQIGQVVKESWWKPN------SQGLLVNAIFFNLSWERTFNPEATYPREFRVNATKSVMIPMMH 206
            .:.|..::     .|:      ::.:||||::|...|:..|.||.|..|.|.....||..:||:.
Human   174 RDMIDNLL-----SPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLA 233

  Fly   207 EDSKFAFGIL---GNLKATAVLVPFSHGD-LRMLLIKP-DQPDGLAALQMKLQAMNILSVARNLT 266
            :.|.|..|..   .:|....:.:|: ||: :.||:..| :....|:|:...:....|.|....:.
Human   234 QLSVFRCGSTSAPNDLWYNFIELPY-HGESISMLIALPTESSTPLSAIIPHISTKTIDSWMSIMV 297

  Fly   267 MMDVFVGIPKFKIHSDLELSPAFEKMGIKDIFKPSK-SFSTLLHRNTNFRIDGVIHVVTFEFQEQ 330
            ...|.|.:|||...:..:|....:.:||.|:|..|| :|:.:...:.|..:..::.....|..|.
Human   298 PKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTGSENLHVSHILQKAKIEVSED 362

  Fly   331 GIGTPSTDVGNGSLTHTFNGVKYFLATHPFAFYIIDNT--SIYFAGHV 376
            |   ........::....:...:|:...||.|:|..|.  ::.|.|.:
Human   363 G---TKASAATTAILIARSSPPWFIVDRPFLFFIRHNPTGAVLFMGQI 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn53F	NP_001036553.1	SERPIN	25..376	CDD:238101	82/371 (22%)
SERPINE2	XP_005246698.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.030