DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn53F and SERPINF1

DIOPT Version :9

Sequence 1:	NP_001036553.1	Gene:	Spn53F / 36931	FlyBaseID:	FBgn0034195	Length:	379	Species:	Drosophila melanogaster
Sequence 2:	NP_001316832.1	Gene:	SERPINF1 / 5176	HGNCID:	8824	Length:	418	Species:	Homo sapiens

Alignment Length:	385	Identity:	81/385 - (21%)
Similarity:	160/385 - (41%)	Gaps:	49/385 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 QLPDELYAAIVNSFS------------NRNIMFSTEMIRSSMLFIYVGVEEDESEQIRKAMHY-- 71
            ::|....||.|::|.            ..|::.|...:.:::..:.:|.|:.....|.:|::|
Human    48 KVPVNKLAAAVSNFGYDLYRVRSSTSPTTNVLLSPLSVATALSALSLGAEQRTESIIHRALYYDL 112

  Fly    72 ------RGTHLSEYKPKTQKIFAMSVKKAPVAKSLTRFYVRQNMKMSTEYRVFMRHTEGRARNIA 130
                  .||    ||.....:.|....    .||.:|....:.:::.:.:...:..:.|....:.
Human   113 ISSPDIHGT----YKELLDTVTAPQKN----LKSASRIVFEKKLRIKSSFVAPLEKSYGTRPRVL 169

  Fly   131 FAREQLD--EVNTFYSHEMGEQIGQVVKESWWKPNSQG-LLVNAIFFNLSWERTFNPEATYPREF 192
            ....:||  |:|.:...:|..::.:..||.   |:... ||:....|...|...|:...|...:|
Human   170 TGNPRLDLQEINNWVQAQMKGKLARSTKEI---PDEISILLLGVAHFKGQWVTKFDSRKTSLEDF 231

  Fly   193 RVNATKSVMIPMMHEDSK--FAFGILGNLKATAVLVPFSHGDLRMLLIKP-DQPDGLAALQMKLQ 254
            .::..::|.:||| .|.|  ..:|:..:|......:|.: |.:.::...| .....|..::..|.
Human   232 YLDEERTVRVPMM-SDPKAVLRYGLDSDLSCKIAQLPLT-GSMSIIFFLPLKVTQNLTLIEESLT 294

  Fly   255 AMNILSVARNLTMMDVFVGIPKFKIHSDLELSPAFEKMGIKDIFKPSKSFSTLLHRNTNFRIDGV 319
            :..|..:.|.|..:...:.:||.|:..:.|::.:.::|.::.:| .|..||.:..:  ..::..|
Human   295 SEFIHDIDRELKTVQAVLTVPKLKLSYEGEVTKSLQEMKLQSLF-DSPDFSKITGK--PIKLTQV 356

  Fly   320 IHVVTFEFQEQGIG-TPSTDVGNGSLTHTFNGVKYFLATHPFAFYI--IDNTSIYFAGHV 376
            .|...||:.|.|.| |||..:....||...:   |.| ..||.|.:  .|..::.|.|.:
Human   357 EHRAGFEWNEDGAGTTPSPGLQPAHLTFPLD---YHL-NQPFIFVLRDTDTGALLFIGKI 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn53F	NP_001036553.1	SERPIN	25..376	CDD:238101	80/379 (21%)
SERPINF1	NP_001316832.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..39
		PEDF	40..415	CDD:239007	81/385 (21%)
		O-glycosylated at one site	371..383		3/11 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010