DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn53F and SERPINE1

DIOPT Version :9

Sequence 1:	NP_001036553.1	Gene:	Spn53F / 36931	FlyBaseID:	FBgn0034195	Length:	379	Species:	Drosophila melanogaster
Sequence 2:	NP_001373389.1	Gene:	SERPINE1 / 5054	HGNCID:	8583	Length:	492	Species:	Homo sapiens

Alignment Length:	428	Identity:	84/428 - (19%)
Similarity:	159/428 - (37%)	Gaps:	110/428 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLLILLGIS-------------RYRAQKNSQLPDELYAAIVNSFSNRNIMFSTEMIRSSMLFIYV 55
            |..::||::             .|.|...|.....::..:..:..:||::||...:.|.:..:.:
Human     7 LTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQL 71

  Fly    56 GVEEDESEQIRKAMHY----RG-----THLSE----------------------------YKPKT 83
            ....:..:||:.||.:    :|     .||.:                            :.|..
Human    72 TTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHF 136

  Fly    84 QKIFAMSVKKAPVAK-SLTRFYVRQNMKMSTEYRVFMRHTEGRARNIAFAREQLDEVNTFYSHEM 147
            .::|..:||:...:: ...||.:...:|         .||:|...|: ..:..:|::...
Human   137 FRLFRSTVKQVDFSEVERARFIINDWVK---------THTKGMISNL-LGKGAVDQLTRL----- 186

  Fly   148 GEQIGQVVKESWWKPNSQGLLVNAIFFNLSWERTFNPEATYPREFRVNATKSVMIPMMHEDSKFA 212
                               :||||::||..|:..|...:|:.|.|..:...:|.:|||.:.:||.
Human   187 -------------------VLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFN 232

  Fly   213 FGILGNLKATAVLVPFS----------HGD-LRMLLIKPDQPD-GLAALQMKLQAMNILSVARNL 265
            :        |....|..          ||| |.|.:..|.:.: .|:||...|.|..|.....|:
Human   233 Y--------TEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNM 289

  Fly   266 TMMDVFVGIPKFKIHSDLELSPAFEKMGIKDIFKPSKSFSTLLHRNTNFRIDGVIHVVTFEFQEQ 330
            |.:...:.:|||.:.::::|....|.:|:.|:|:..::..|.|.......:...:..|..|..|.
Human   290 TRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNES 354

  Fly   331 G-IGTPSTDVGNGSLTHTFNGVKYFLATHPFAFYIIDN 367
            | :.:.||.|    :.......:..:...||.|.:..|
Human   355 GTVASSSTAV----IVSARMAPEEIIMDRPFLFVVRHN 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn53F	NP_001036553.1	SERPIN	25..376	CDD:238101	78/394 (20%)
SERPINE1	NP_001373389.1	serpinE1_PAI-1	29..393	CDD:381007	81/406 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020