DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn53F and SERPIND1

DIOPT Version :9

Sequence 1:	NP_001036553.1	Gene:	Spn53F / 36931	FlyBaseID:	FBgn0034195	Length:	379	Species:	Drosophila melanogaster
Sequence 2:	NP_000176.2	Gene:	SERPIND1 / 3053	HGNCID:	4838	Length:	499	Species:	Homo sapiens

Alignment Length:	402	Identity:	87/402 - (21%)
Similarity:	172/402 - (42%)	Gaps:	46/402 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLLILLGISRYRAQK--NSQLPDELYAAI---VNSFSNRNIMFSTEMIRSSMLFIYVGVEEDESE 63
            :|.:..|.||.:...  |::....||..:   ||:|.  ||..:...|.::|..|.:|::.:..|
Human   113 ILQLFHGKSRIQRLNILNAKFAFNLYRVLKDQVNTFD--NIFIAPVGISTAMGMISLGLKGETHE 175

  Fly    64 QIRKAMHYRG-----------THLSEYKPKTQKIFAMSVKKAPVAKSLTRFYVRQNMKMSTEYRV 117
            |:...:|::.           |..:.::..|.::|..:.  ....:|:...|:::...:..:::.
Human   176 QVHSILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNF--GYTLRSVNDLYIQKQFPILLDFKT 238

  Fly   118 FMRHTEGRARNIAFAREQLDE------VNTFYSHEMGEQIGQVVKESWWK--PNSQGLLVNAIFF 174
                   :.|...||..|:.:      ::...:|.|....| ::|::...  |.:|.:::|.|:|
Human   239 -------KVREYYFAEAQIADFSDPAFISKTNNHIMKLTKG-LIKDALENIDPATQMMILNCIYF 295

  Fly   175 NLSWERTFNPEATYPREFRVNATKSVMIPMMHEDSKFAFGILGNLKATAVLVPFSHGDLRMLLIK 239
            ..||...|..|.|:...||:|..:.|.:.||.....|.......|....:.:.:. |.:.||::.
Human   296 KGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYV-GGISMLIVV 359

  Fly   240 PDQPDGLAALQMKLQAMNILSVARNLTMMDVFVGIPKFKIHSDLELSPAFEKMGIKDIFKPSKSF 304
            |.:..|:..|:.:|....:....:::|.....|.:||||:..:..|..:.:.|||:.:|..:.:.
Human   360 PHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNM 424

  Fly   305 STLLHRNTNFRIDGVIHVVTFEFQEQGI-GTPSTDVGNGSLTHTFNGVKYFLATHPFAFYIIDN- 367
            :.:  .:....||...|..|....|:|. .|..|.||...|:....    |....||.|.|.::
Human   425 AGI--SDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVR----FTVDRPFLFLIYEHR 483

  Fly   368 -TSIYFAGHVTS 378
             :.:.|.|.|.:
Human   484 TSCLLFMGRVAN 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn53F	NP_001036553.1	SERPIN	25..376	CDD:238101	81/375 (22%)
SERPIND1	NP_000176.2	HCII	62..497	CDD:239002	87/402 (22%)
		Chemotactic activity	68..79
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	73..97
		Glycosaminoglycan-binding site	192..212		3/19 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020