Protein Alignment Spn53F and SERPINB1

DIOPT Version :10

• Sequence 1: NP_001036553.1
• Gene: Spn53F / 36931
• FlyBaseID: FBgn0034195
• Length: 379
• Species: Drosophila melanogaster
• Sequence 2: NP_109591.1
• Gene: SERPINB1 / 1992
• HGNCID: 3311
• Length: 379
• Species: Homo sapiens
• Alignment Length: 390
• Identity: 95/390 - (24%)
• Similarity: 173/390 - (44%)
• Gaps: 49/390 - (12%)

  Fly    19 NSQLPDELYAAIVNSFSNRNIMFSTEMIRSSMLFIYVGVEEDESEQIRKAMHYRGTHLSEYKPKT 83
            |::...:|:.|:..:....||..|...|.|:|..:::|...:.:.|:.|..|:  ..:.|...:.
Human     8 NTRFALDLFLALSENNPAGNIFISPFSISSAMAMVFLGTRGNTAAQLSKTFHF--NTVEEVHSRF 70

  Fly    84 QKIFAMSVKKAP--VAKSLTRFYVRQNMKMSTEYRVFMRHTEGRARNIAFAREQLDEVNTFYSHE 146
            |.:.|...|:..  :.|...|.|..:......|:.|..:.|.|           .|..:..:.|
Human    71 QSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTYG-----------ADLASVDFQH- 123

  Fly   147 MGEQIGQVVKESWWKPNSQG-----------------LLVNAIFFNLSWERTFNPEATYPREFRV 194
            ..|...:.:.: |.|..::|                 :|||||:|..:|:..|..|||....||:
Human   124 ASEDARKTINQ-WVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEATTNAPFRL 187

  Fly   195 NATKSVMIPMMHEDSKFAFGILGNLKATAVLVPFSHGDLRMLLIKP----DQPDGLAAL--QMKL 253
            |......:.||::..|||:|.:.:||...:.:|:...:|.|:::.|    |:..||..:  |:.|
Human   188 NKKDRKTVKMMYQKKKFAYGYIEDLKCRVLELPYQGEELSMVILLPDDIEDESTGLKKIEEQLTL 252

  Fly   254 QAMNILSVARNLTMMDVFVGIPKFKIHSDLELSPAFEKMGIKDIFKPSKSFSTLLHRNTNFRIDG 318
            :.::..:...||..::|.|.:|:||:.....|:....::|::|:|..||:..:.:....:..|..
Human   253 EKLHEWTKPENLDFIEVNVSLPRFKLEESYTLNSDLARLGVQDLFNSSKADLSGMSGARDIFISK 317

  Fly   319 VIHVVTFEFQEQGIGTPSTDVGNGSLTHTFNGV---KYFLATHPFAFYIIDNT--SIYFAGHVTS 378
            ::|....|..|:|....:...|    ..||..:   :.|.|.|||.|:|..|:  ||.|.|..:|
Human   318 IVHKSFVEVNEEGTEAAAATAG----IATFCMLMPEENFTADHPFLFFIRHNSSGSILFLGRFSS 378

  Fly   379  378
            Human   379  378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn53F	NP_001036553.1	serpin42Dd-like_insects	20..379	CDD:381070	94/389 (24%)
SERPINB1	NP_109591.1	serpinB1_LEI	1..379	CDD:381028	95/390 (24%)
		CARD-binding motif (CBM). /evidence=ECO:0000269|PubMed:30692621	351..379		13/28 (46%)