Protein Alignment Spn53F and Serpina12

DIOPT Version :10

• Sequence 1: NP_001036553.1
• Gene: Spn53F / 36931
• FlyBaseID: FBgn0034195
• Length: 379
• Species: Drosophila melanogaster
• Sequence 2: NP_620180.2
• Gene: Serpina12 / 191570
• RGDID: 708485
• Length: 414
• Species: Rattus norvegicus
• Alignment Length: 403
• Identity: 85/403 - (21%)
• Similarity: 159/403 - (39%)
• Gaps: 67/403 - (16%)

  Fly    11 ISRYRAQK--------NSQLPDELYAAIVNSFSNRNIMFSTEMIRSSMLFIYVGVEEDESEQIR- 66
            :..:|.:|        |.:...:|...:.::....||..|...|.::...:.:|.:....|:||
  Rat    36 VQEWRGKKDARELTRHNMEFGFKLLQRLASNSRQGNIFLSPLSISTAFSMLSLGAQNSTLEEIRE 100

  Fly    67 ----KAMHYRGTHLSEYKPKTQKIFAMSVKKAPVAKSLTRFYVRQNMKMSTEYRVFM-RHTEGRA 126
                |.|..|..|:.         |...::|      |.|  ..|::|||....:|| :....:.
  Rat   101 GFNFKEMSDRDMHMG---------FHYLLQK------LNR--ETQDVKMSIGNALFMDQRLRPQQ 148

  Fly   127 RNIAFAREQLD----------------EVNTFYSHEMGEQIGQVVKESWWKPNSQGLLVNAIFFN 175
            |.:..|:...|                .:|.:.|.:...:|..:||..  .|.:..||.|.|:|.
  Rat   149 RFLKLAKNLYDADMILTNFQDLENTQKNINKYISRKTHNRIENMVKNI--DPGTVMLLTNYIYFQ 211

  Fly   176 LSWERTFNPEATYPREFRVNATKSVMIPMMHEDSKFAFGILGNLKATAVLVPFSHGDLRMLLIKP 240
            ..|:..|:|:.|...:|.:...|:|.:|||.:...:.......|..|.:.:|:.. ::....:.|
  Rat   212 GRWQYEFDPKQTKEEDFFIEEGKTVKVPMMFQRGMYDMAYDSQLSCTILEMPYRR-NITATFVLP 275

  Fly   241 DQPDGLAALQMKLQAMNILSVARNL---TMMDVFVGIPKFKIHSDLELSPAFEKMGIKDIFKPSK 302
            |. ..|..|:..||| :|.:..::|   .::||:|  |:..|.:...:.....::||..||:...
  Rat   276 DS-GKLRLLEQGLQA-DIFAKWKSLLSKRVVDVWV--PRLHISATYNMKKVLSRLGISKIFEEHG 336

  Fly   303 SFSTLLHRNTNFRIDGVIHVVTFEFQEQGIGTPSTD--VGNGSLTHTFNGVKYFLATHPFAFYII 365
            .. |.:..:.:.::...:|.......|:|     |:  .|:|:.|......:......||...|.
  Rat   337 DL-TRISSHRSLKVGEAVHKAELRMNEKG-----TEGAAGSGAQTLPMETPRRMKLNAPFLMMIY 395

  Fly   366 DN--TSIYFAGHV 376
            :|  .|:.|...:
  Rat   396 ENLMPSMIFLARI 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn53F	NP_001036553.1	serpin42Dd-like_insects	20..379	CDD:381070	82/386 (21%)
Serpina12	NP_620180.2	serpinA12_vaspin	40..411	CDD:381026	85/399 (21%)
		Reactive center loop. /evidence=ECO:0000250|UniProtKB:Q8IW75	364..382		5/22 (23%)