DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn53F and SERPINA12

DIOPT Version :9

Sequence 1:	NP_001036553.1	Gene:	Spn53F / 36931	FlyBaseID:	FBgn0034195	Length:	379	Species:	Drosophila melanogaster
Sequence 2:	NP_001291390.1	Gene:	SERPINA12 / 145264	HGNCID:	18359	Length:	414	Species:	Homo sapiens

Alignment Length:	388	Identity:	80/388 - (20%)
Similarity:	153/388 - (39%)	Gaps:	51/388 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 AQKNSQLPDELYAAIVNSFSNRNIMFSTEMIRSSMLFIYVGVEEDESEQIRKAMHYR-------- 72
            |::|..|..:|...:......|||..|...|.::...:.:|.::...::|::..::|
Human    49 ARQNMDLGFKLLKKLAFYNPGRNIFLSPLSISTAFSMLCLGAQDSTLDEIKQGFNFRKMPEKDLH 113

  Fly    73 -GTH--LSEYKPKTQKIFAMSVKKAPVAKSLTRFYVRQNMKMSTEYRVFMRHTEG---------R 125
             |.|  :.|...|||.:      |..:..:|   ::.|.::   ..|.|:...:.         .
Human   114 EGFHYIIHELTQKTQDL------KLSIGNTL---FIDQRLQ---PQRKFLEDAKNFYSAETILTN 166

  Fly   126 ARNIAFAREQLDEVNTFYSHEMGEQIGQVVKESWWKPNSQGLLVNAIFFNLSWERTFNPEATYPR 190
            .:|:..|::|   :|.|.|.:...:|..:::..  .|.:..||.|.|||...|:..|:|..|...
Human   167 FQNLEMAQKQ---INDFISQKTHGKINNLIENI--DPGTVMLLANYIFFRARWKHEFDPNVTKEE 226

  Fly   191 EFRVNATKSVMIPMMHEDSKFAFGILGNLKATAVLVPFSHGDLRMLLIKPDQPDGLAALQMKLQA 255
            :|.:....||.:|||.....:..|....|..|.:.:|:.. ::..:.|.||: ..|..|:..||.
Human   227 DFFLEKNSSVKVPMMFRSGIYQVGYDDKLSCTILEIPYQK-NITAIFILPDE-GKLKHLEKGLQV 289

  Fly   256 MNILSVARNLTMMDVFVGIPKFKIHSDLELSPAFEKMGIKDIFKPSKSFSTLL-HRNTNFRIDGV 319
            .........|:...|.|.:|:..:....:|......:|:..||:.....:.:. ||  :.::...
Human   290 DTFSRWKTLLSRRVVDVSVPRLHMTGTFDLKKTLSYIGVSKIFEEHGDLTKIAPHR--SLKVGEA 352

  Fly   320 IHVVTFEFQEQGIGTPSTD--VGNGSLTHTFNGVKYFLATHPFAFYIIDN--TSIYFAGHVTS 378
            :|....:..|:|     |:  .|.|:.|.............|:...|...  .|:.|.|.:.:
Human   353 VHKAELKMDERG-----TEGAAGTGAQTLPMETPLVVKIDKPYLLLIYSEKIPSVLFLGKIVN 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn53F	NP_001036553.1	SERPIN	25..376	CDD:238101	77/375 (21%)
SERPINA12	NP_001291390.1	serpinA12_vaspin	40..411	CDD:381026	80/388 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010