Protein Alignment Spn53F and SERPINA12

DIOPT Version :10

• Sequence 1: NP_001036553.1
• Gene: Spn53F / 36931
• FlyBaseID: FBgn0034195
• Length: 379
• Species: Drosophila melanogaster
• Sequence 2: NP_776249.1
• Gene: SERPINA12 / 145264
• HGNCID: 18359
• Length: 414
• Species: Homo sapiens
• Alignment Length: 388
• Identity: 80/388 - (20%)
• Similarity: 153/388 - (39%)
• Gaps: 51/388 - (13%)

  Fly    16 AQKNSQLPDELYAAIVNSFSNRNIMFSTEMIRSSMLFIYVGVEEDESEQIRKAMHYR-------- 72
            |::|..|..:|...:......|||..|...|.::...:.:|.::...::|::..::|
Human    49 ARQNMDLGFKLLKKLAFYNPGRNIFLSPLSISTAFSMLCLGAQDSTLDEIKQGFNFRKMPEKDLH 113

  Fly    73 -GTH--LSEYKPKTQKIFAMSVKKAPVAKSLTRFYVRQNMKMSTEYRVFMRHTEG---------R 125
             |.|  :.|...|||.:      |..:..:|   ::.|.::   ..|.|:...:.         .
Human   114 EGFHYIIHELTQKTQDL------KLSIGNTL---FIDQRLQ---PQRKFLEDAKNFYSAETILTN 166

  Fly   126 ARNIAFAREQLDEVNTFYSHEMGEQIGQVVKESWWKPNSQGLLVNAIFFNLSWERTFNPEATYPR 190
            .:|:..|::|   :|.|.|.:...:|..:::..  .|.:..||.|.|||...|:..|:|..|...
Human   167 FQNLEMAQKQ---INDFISQKTHGKINNLIENI--DPGTVMLLANYIFFRARWKHEFDPNVTKEE 226

  Fly   191 EFRVNATKSVMIPMMHEDSKFAFGILGNLKATAVLVPFSHGDLRMLLIKPDQPDGLAALQMKLQA 255
            :|.:....||.:|||.....:..|....|..|.:.:|:.. ::..:.|.||: ..|..|:..||.
Human   227 DFFLEKNSSVKVPMMFRSGIYQVGYDDKLSCTILEIPYQK-NITAIFILPDE-GKLKHLEKGLQV 289

  Fly   256 MNILSVARNLTMMDVFVGIPKFKIHSDLELSPAFEKMGIKDIFKPSKSFSTLL-HRNTNFRIDGV 319
            .........|:...|.|.:|:..:....:|......:|:..||:.....:.:. ||  :.::...
Human   290 DTFSRWKTLLSRRVVDVSVPRLHMTGTFDLKKTLSYIGVSKIFEEHGDLTKIAPHR--SLKVGEA 352

  Fly   320 IHVVTFEFQEQGIGTPSTD--VGNGSLTHTFNGVKYFLATHPFAFYIIDN--TSIYFAGHVTS 378
            :|....:..|:|     |:  .|.|:.|.............|:...|...  .|:.|.|.:.:
Human   353 VHKAELKMDERG-----TEGAAGTGAQTLPMETPLVVKIDKPYLLLIYSEKIPSVLFLGKIVN 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn53F	NP_001036553.1	serpin42Dd-like_insects	20..379	CDD:381070	78/384 (20%)
SERPINA12	NP_776249.1	serpinA12_vaspin	40..411	CDD:381026	80/388 (21%)
		Reactive center loop. /evidence=ECO:0000269|PubMed:26529565, ECO:0000305|PubMed:23370777, ECO:0000305|PubMed:26199422	364..382		5/22 (23%)