DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn53F and Serpinh1

DIOPT Version :9

Sequence 1:	NP_001036553.1	Gene:	Spn53F / 36931	FlyBaseID:	FBgn0034195	Length:	379	Species:	Drosophila melanogaster
Sequence 2:	NP_001104513.1	Gene:	Serpinh1 / 12406	MGIID:	88283	Length:	417	Species:	Mus musculus

Alignment Length:	376	Identity:	78/376 - (20%)
Similarity:	151/376 - (40%)	Gaps:	28/376 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 AQKNSQLPDELYAAIVNSFSNRNIMFSTEMIRSSMLFIYVGVEEDESEQIRKAMHYRGTHLSEYK 80
            |::::.|...||.|:....:..||:.|..::.||:..:.:|.:...:.|.:..       ||..|
Mouse    43 AERSTGLAFSLYQAMAKDQAVENILLSPLVVASSLGLVSLGGKATTASQAKAV-------LSAEK 100

  Fly    81 PKTQKI----------FAMSVKKAPVAKSLTRFYVRQNMKMSTEY-RVFMRHTEGRARNIAF--A 132
            .:.:::          .:.|..:....|..:|.|...::..:.:: |...:|.......|.|  .
Mouse   101 LRDEEVHTGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDK 165

  Fly   133 REQLDEVNTFYSHEMGEQIGQVVKESWWKPNSQGLLVNAIFFNLSWERTFNPEATYPREFRVNAT 197
            |..|..:|.:.|.....::.:|.|:.  :.....|||||:||...|:..|:.:....|.|.|..:
Mouse   166 RSALQSINEWASQTTDGKLPEVTKDV--ERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRS 228

  Fly   198 KSVMIPMMHEDSKFAFGILGNLKATAVLVPFSHGDLRMLLIKPDQPDGLAALQMKLQAMNILSVA 262
            .:|.:.|||....:.:......|...|.:|.:|....::::.|...:.|..|:..|....:.:..
Mouse   229 YTVGVTMMHRTGLYNYYDDEKEKLQMVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKAWM 293

  Fly   263 RNLTMMDVFVGIPKFKIHSDLELSPAFEKMGIKDIFKPSKSFSTLLHRNTNFRIDGVIHVVTFEF 327
            ..:....|.:.:||..:....:|......:|:.:....:|:..:.:....:..:..|.|...||:
Mouse   294 GKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFEW 358

  Fly   328 QEQGIGTPSTDVGNGSLTHTFNGVKYFLATHPFAFYIIDNT--SIYFAGHV 376
            ..:|........|...|    ...|.|.|.|||.|.:.||.  |:.|.|.:
Mouse   359 DTEGNPFDQDIYGREEL----RSPKLFYADHPFIFLVRDNQSGSLLFIGRL 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn53F	NP_001036553.1	SERPIN	25..376	CDD:238101	76/365 (21%)
Serpinh1	NP_001104513.1	serpinH1_CBP1	35..416	CDD:381003	78/376 (21%)
Serpinh1	NP_001104513.1	Prevents secretion from ER. /evidence=ECO:0000305	414..417
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010