DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn53F and Serping1

DIOPT Version :9

Sequence 1:	NP_001036553.1	Gene:	Spn53F / 36931	FlyBaseID:	FBgn0034195	Length:	379	Species:	Drosophila melanogaster
Sequence 2:	NP_033906.2	Gene:	Serping1 / 12258	MGIID:	894696	Length:	504	Species:	Mus musculus

Alignment Length:	389	Identity:	67/389 - (17%)
Similarity:	145/389 - (37%)	Gaps:	62/389 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 AQKNSQLPD---ELYAAI-VNSFSNRNIMFSTEMIRSSMLFIYVGVEEDESEQIRKAMHYRGTHL 76
            |:.:..|.|   :||.|. ....:..|:.||...|.|.:..:.:|..:.....:...:.|
Mouse   145 AKLSEALTDFSVKLYHAFSATKMAKTNMAFSPFSIASLLTQVLLGAGDSTKSNLESILSY----- 204

  Fly    77 SEYKPKTQKIFAMSVK--KAPVAKSLTRFYVRQNMKMSTEYRVFMRHTEGRARNI--AFAREQLD 137
                ||.......::|  .:....|:::.:...::.:...|....:...|.:..:  ..:...|:
Mouse   205 ----PKDFACVHQALKGFSSKGVTSVSQIFHSPDLAIRDTYVNASQSLYGSSPRVLGPDSAANLE 265

  Fly   138 EVNTFYSHEMGEQIGQVVKESWWKPNSQGL-LVNAIFFNLSWERTFNPEATYPREFRVNATKSVM 201
            .:||:.:.....:|.:::..   .|:...| |:||::.:..|:.||.|             |.:|
Mouse   266 LINTWVAENTNHKIRKLLDS---LPSDTCLVLLNAVYLSAKWKITFEP-------------KKMM 314

  Fly   202 IPMMHEDSKFAFGILGN------------LKATAVLVPFSHGDLRMLLIKPDQP-DGLAALQMKL 253
            .|..:::|.....::.:            |||....:..|| :|..:::.|..| ..|..::..|
Mouse   315 APFFYKNSMIKVPMMSSVKYPVAQFDDHTLKAKVGQLQLSH-NLSFVIVVPVFPKHQLKDVEKAL 378

  Fly   254 QAMNILSVARNLTM---MDVFVGIPKFKIHSDLELSPAFEKMGIKDIFKPSKSFSTL-LHRNTNF 314
            ......::.:.|.:   :..::.:|..|:.|..::....||:   :.|..:...:.. |..:.:.
Mouse   379 NPTVFKAIMKKLELSKFLPTYLTMPHIKVKSSQDMLSVMEKL---EFFDFTYDLNLCGLTEDPDL 440

  Fly   315 RIDGVIHVVTFEFQEQGIGTPSTDVGNGSLTHTFNGVKYFLATHPFAFYIIDNTSIY--FAGHV 376
            ::..:.|....|..|.|:     :....|.......:..|....||.|.:.|....:  |.|.|
Mouse   441 QVSAMKHETVLELTESGV-----EAAAASAISFGRSLPIFEVQRPFLFLLWDQQHRFPVFMGRV 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn53F	NP_001036553.1	SERPIN	25..376	CDD:238101	63/375 (17%)
Serping1	NP_033906.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..67
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..141
		serpinG1_C1-INH	141..500	CDD:381006	67/389 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100