Protein Alignment Spn53F and SERPINA3

DIOPT Version :10

• Sequence 1: NP_001036553.1
• Gene: Spn53F / 36931
• FlyBaseID: FBgn0034195
• Length: 379
• Species: Drosophila melanogaster
• Sequence 2: NP_001076.2
• Gene: SERPINA3 / 12
• HGNCID: 16
• Length: 423
• Species: Homo sapiens
• Alignment Length: 397
• Identity: 90/397 - (22%)
• Similarity: 163/397 - (41%)
• Gaps: 51/397 - (12%)

  Fly     9 LGISRYRAQKNSQLPDELYAAIVNSFSNRNIMFSTEMIRSSMLFIYVGVEEDESEQIRKAMHYRG 73
            ||:    |..|......||..:|....::|::||...|.:::.|:.:|.......:|.|.:.:..
Human    47 LGL----ASANVDFAFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKFNL 107

  Fly    74 THLSEYKPKTQKIFAMSVKKAPVAKSLTRFYVRQNMKMSTEYRVFMRHTEGRAR---NIAFAREQ 135
            |..||  .:..:.|...::....:....:..:...|.:..:..:..|.||...|   :.|||.:.
Human   108 TETSE--AEIHQSFQHLLRTLNQSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEAFATDF 170

  Fly   136 LDE------VNTFYSHEMGEQIGQVVKESWWKPNSQGL--LVNAIFFNLSWERTFNPEATYPREF 192
            .|.      :|.:..:....:|..::|:.    :||.:  |||.|||...||..|:|:.|:...|
Human   171 QDSAAAKKLINDYVKNGTRGKITDLIKDL----DSQTMMVLVNYIFFKAKWEMPFDPQDTHQSRF 231

  Fly   193 RVNATKSVMIPMM---------HEDSKFAFGILGNLKATAVLVPFSHGDLRMLLIKPDQPDGLAA 248
            .::..|.||:|||         ..|.:        |..|.|.:.:: |:...|.|.||| |.:..
Human   232 YLSKKKWVMVPMMSLHHLTIPYFRDEE--------LSCTVVELKYT-GNASALFILPDQ-DKMEE 286

  Fly   249 LQMKLQAMNILSVARNLTMMDV-FVGIPKFKIHSDLELSPAFEKMGIKDIFKPSKSFSTLLHRNT 312
            ::..|....:.....:|...:: .:.:|||.|..|..|:....::||::.|......|.:....
Human   287 VEAMLLPETLKRWRDSLEFREIGELYLPKFSISRDYNLNDILLQLGIEEAFTSKADLSGITGAR- 350

  Fly   313 NFRIDGVIHVVTFEFQEQGIGTPSTDVGN----GSLTHTFNGVKYFLATHPFAFYII--DNTSIY 371
            |..:..|:|....:..|:|....:.....    .:|..|...|::   ..||...|:  |..:|:
Human   351 NLAVSQVVHKAVLDVFEEGTEASAATAVKITLLSALVETRTIVRF---NRPFLMIIVPTDTQNIF 412

  Fly   372 FAGHVTS 378
            |...||:
Human   413 FMSKVTN 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn53F	NP_001036553.1	serpin42Dd-like_insects	20..379	CDD:381070	86/386 (22%)
SERPINA3	NP_001076.2	serpinA3_A1AC	40..421	CDD:381019	90/397 (23%)
		RCL	369..394		3/24 (13%)
		O-glycosylated at one site	381..389		1/7 (14%)