Protein Alignment CG15611 and Kalrn

DIOPT Version :10

• Sequence 1: NP_611189.2
• Gene: CG15611 / 36930
• FlyBaseID: FBgn0034194
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: XP_038944566.1
• Gene: Kalrn / 84009
• RGDID: 621865
• Length: 2989
• Species: Rattus norvegicus
• Alignment Length: 474
• Identity: 110/474 - (23%)
• Similarity: 201/474 - (42%)
• Gaps: 74/474 - (15%)

  Fly    41 DNGKSIDVVDKAPAKE-CPLLESQSPSSPIATTLPKSQASSNGKLEKQISLLDSDSGISLSSINT 104
            |..||.|:....|..| .|..:|....|.......:....|:..|...:.:.|:|.    :....
  Rat  1798 DGRKSFDLGSPKPGDETTPQGDSADEKSKKGWGEDEPDEESHTPLPPPMKIFDNDP----TQDEM 1858

  Fly   105 CSTTAANSSPTYRAP------NGFHSFPSHTLSFETLGDEYH---EDEDTLSLENLFPC------ 154
            .|..||..:|| ..|      :.........|:.|  |..|.   :|......|.:.|.
  Rat  1859 SSLLAARQAPT-DVPTAADLVSAIEKLVKSKLTLE--GGSYRGSLKDPTVCLNEGMAPPTPPRNL 1920

  Fly   155 -DQTEIYASKKISFIIDELIQTEVNYVNNLKKGMLNYGQLKDVED--LPEALSGETKQKMLLGNI 216
             ::.:..|.:...|:::||:|||.:||.:|  |::..|.:|.:|:  :||.:.|  |:|::.|||
  Rat  1921 EEEQKAKALRGRMFVLNELVQTEKDYVKDL--GIVVEGFMKRIEEKGVPEDMRG--KEKIVFGNI 1981

  Fly   217 KEILELHEKEILPLMLRNQRDLKGLFDEFAAHFEKNSFYCYVSFTMGKKSSMQLRQDNRLWLQTY 281
            .:|.:.|:...|..:.:..::...|...|..|..|  .:.||.:...|..|..:..:...:.:..
  Rat  1982 HQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERK--LHIYVWYCQNKPRSEYIVAEYDAYFEEV 2044

  Fly   282 QTQIKDKLGIDSFLVQPIQRLTRYPLLLQQFISEFYKSGISCKPVLTAV---CKLETRMRRALDV 343
            :.:|..:|.:..||::||||:|:|.|||:.|:....|:|:.|..:..||   |.:..|
  Rat  2045 KQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKR------- 2102

  Fly   344 VNQAEEIPNIEELNELD--------VLQLGNFRRATEFDAQHFPTRKKYRSKVFLFDRCLVCTE- 399
               ..::.|:..|...:        :||...| ...|.|| ...:|.|.| :||||::.::.:|
  Rat  2103 ---CNDMMNLGRLQGFEGTLTAQGKLLQQDTF-YVIELDA-GMQSRTKER-RVFLFEQIVIFSEL 2161

  Fly   400 VRKKRLA----YRQHYNWEHVELQRPLDSVSSNANKIINLLVKQEEGGSSVGSKREEYSFMAAEA 460
            :||..|.    :::.....::.|:..:|.     :.....|:.:|..        |.....||..
  Rat  2162 LRKGSLTPGYMFKRSIKMNYLVLEEDVDD-----DPCKFALMNRETS--------ERVILQAANP 2213

  Fly   461 SVVKQWLQATHKIIEIARN 479
            .:.:.|:|..::::|..|:
  Rat  2214 DIQQAWVQDINQVLETQRD 2232

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15611	NP_611189.2	RhoGEF	167..313	CDD:470622	45/147 (31%)
Kalrn	XP_038944566.1	SEC14	42..180	CDD:214706
		SPEC	193..413	CDD:238103
		SPEC	314..539	CDD:238103
		SPEC	540..769	CDD:238103
		SPEC	894..1132	CDD:238103
		SPEC	1138..1238	CDD:197544
		RhoGEF	1287..1457	CDD:238091
		PH1_Kalirin_Trio_like	1464..1586	CDD:270060
		SH3_Kalirin_1	1652..1711	CDD:212786
		SH3-RhoG_link	1708..1892	CDD:465196	20/98 (20%)
		RhoGEF	1935..2104	CDD:459876	52/184 (28%)
		PH2_Kalirin_Trio_p63RhoGEF	2109..2243	CDD:270061	29/140 (21%)
		SH3_Kalirin_2	2327..2385	CDD:212787
		I-set	2474..2568	CDD:400151
		Ig strand B	2491..2495	CDD:409353
		Ig strand C	2504..2508	CDD:409353
		Ig strand E	2534..2538	CDD:409353
		Ig strand F	2548..2553	CDD:409353
		Ig strand G	2561..2564	CDD:409353
		FN3	2572..2663	CDD:238020
		STKc_Kalirin_C	2693..2940	CDD:271017