Protein Alignment CG15611 and VAV2

DIOPT Version :10

• Sequence 1: NP_611189.2
• Gene: CG15611 / 36930
• FlyBaseID: FBgn0034194
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: XP_047279801.1
• Gene: VAV2 / 7410
• HGNCID: 12658
• Length: 919
• Species: Homo sapiens
• Alignment Length: 509
• Identity: 101/509 - (19%)
• Similarity: 183/509 - (35%)
• Gaps: 125/509 - (24%)

  Fly    53 PAKECPLLESQSPSSPIATTLPKSQASSNGKLEKQI--SLLDSDSGISLSSINTCSTTAANSSPT 115
            |...|.|:..:.....:.|          |:.|.||  |.|....|..||.:...|..:..|..:
Human   145 PVDFCTLMSGRCRQVLLQT----------GRCESQICVSGLGQRDGPFLSPVMVISAVSRLSLHS 199

  Fly   116 YRAPNGFHSFPSHTL---------SFETLGDEYHEDEDTLSLENLFPCD-----------QTEIY 160
            .....|...|||...         |.|.|.||:...||   :.:..||:           :.|:.
Human   200 IAQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGED---IYDCVPCEDGGDDIYEDIIKVEVQ 261

  Fly   161 ASKKISFIID--------ELIQTEVNYVNNLKKGMLNYGQLKDVEDLPEALSGETKQKMLLGNIK 217
            ...|:....|        |:.:||..|...|:....||     :..|...||......:.: |::
Human   262 QPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNY-----MSPLRLVLSPADMAAVFI-NLE 320

  Fly   218 EILELHEK-------------EILPLMLRNQRDLKGLFDEFAAHFEKNSFYCYVSFTMGKKSSMQ 269
            :::::|..             ..|..:..:.::...::.|:.:|.|      :...|:.:  .:.
Human   321 DLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHME------HAQNTLNQ--LLA 377

  Fly   270 LRQDNRLWLQTYQTQIKD-KLGIDSFLVQPIQRLTRYPLLLQQFISEFYK--SGISCKPVLTAVC 331
            .|:|.|..::....:::| |..:...||.|:||:.:|.|||::.:|...:  .....|..|.|:.
Human   378 SREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEAMQ 442

  Fly   332 KLETRMRRALDVVNQAEEIPNIEEL-NELDVLQLGNFRRATEFDAQHFPTRKKYRSKV------- 388
            .|...:.   :|....|.:..|.|. :.::.||:    :..||.........|.||.|
Human   443 DLAMYIN---EVKRDKETLRKISEFQSSIENLQV----KLEEFGRPKIDGELKVRSIVNHTKQDR 500

  Fly   389 --FLFDR-CLVCTEVRKKRLAYRQHYNWEHVEL-----QRPLDSVSSNAN--------KIINLLV 437
              ||||: .:||.         |:.|::|..|:     .:..|...:|.:        .:|:|..
Human   501 YLFLFDKVVIVCK---------RKGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQG 556

  Fly   438 KQEEGGSSVGSKREEYSFMAAEASVVKQWLQATHKIIEIARNEHARRNTFSLPM 491
            ||            .:.|......:.::|::.....:...:.:.|..|..|..|
Human   557 KQ------------GFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQM 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15611	NP_611189.2	RhoGEF	167..313	CDD:470622	32/167 (19%)
VAV2	XP_047279801.1	CH_SF	2..110	CDD:469584
		RhoGEF	277..450	CDD:214619	36/189 (19%)
		PH_Vav	464..586	CDD:269930	26/146 (18%)
		C1_VAV2	589..646	CDD:410418	4/10 (40%)
		SH3_VAV2_1	660..719	CDD:212913
		SH2_Vav2	737..839	CDD:198269
		SH3_VAV2_2	860..917	CDD:212910