Protein Alignment CG15611 and VAV1

DIOPT Version :10

• Sequence 1: NP_611189.2
• Gene: CG15611 / 36930
• FlyBaseID: FBgn0034194
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_005419.2
• Gene: VAV1 / 7409
• HGNCID: 12657
• Length: 845
• Species: Homo sapiens
• Alignment Length: 498
• Identity: 99/498 - (19%)
• Similarity: 178/498 - (35%)
• Gaps: 158/498 - (31%)

  Fly    83 KLEKQISLLD-SDSGISLSSINTCSTT--AANSSPTYRAPNGFHSFPSHTLSFETLGDE------ 138
            :|.:...|.| .|.|..:.:::..|.|  |.|        .|...||:..   |::|||
Human    92 ELFEAFDLFDVQDFGKVIYTLSALSWTPIAQN--------RGIMPFPTEE---ESVGDEDIYSGL 145

  Fly   139 -------YHEDEDTLSLENLFPC------DQTEIY----ASKKISF------------IIDELIQ 174
                   ..||||      |:.|      :..|||    .|:.:|.            .:.|:.|
Human   146 SDQIDDTVEEDED------LYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLREIQQ 204

  Fly   175 TEVNYVNNLKKGMLNYGQLKDVEDL--PEALSGETKQKMLLGNIKEILELHEKEILPLMLRNQRD 237
            ||..|.:.|  |.:....||.::..  |:.:      :::..||:::|.:|..     .|:..::
Human   205 TEEKYTDTL--GSIQQHFLKPLQRFLKPQDI------EIIFINIEDLLRVHTH-----FLKEMKE 256

  Fly   238 LKG------LFDEFAAHFEKNSFYCYVSFTMGKKSSMQ-------LRQDNRLWLQTYQTQIKD-K 288
            ..|      |:..|..:  |..|..|..:....:|:.:       .|:|.::.|:....:..: :
Human   257 ALGTPGAANLYQVFIKY--KERFLVYGRYCSQVESASKHLDRVAAAREDVQMKLEECSQRANNGR 319

  Fly   289 LGIDSFLVQPIQRLTRYPLLLQQFISEFYKSGISCKPVLTAVCKLETRMRRALDVVNQAEEIPNI 353
            ..:...|:.|:||:.:|.||||:.:..            |.....:..:|.|||.:....:..|.
Human   320 FTLRDLLMVPMQRVLKYHLLLQELVKH------------TQEAMEKENLRLALDAMRDLAQCVNE 372

  Fly   354 EELNELDVLQLGNFRRATE-------------FDAQHFPTRKKYRSKV----FLFDRC-LVCT-- 398
            .:.:...:.|:.||:.:.|             .|.:...|..:.|||:    ||.|:. |:|.
Human   373 VKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRR 437

  Fly   399 ---------------EVRKKRLAYRQHYNWEHVELQRPLDSVSSNANKIINLLVKQEEGGSSVGS 448
                           :||......|.:..|.|                 :.||::.:      |:
Human   438 GDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSH-----------------MFLLIEDQ------GA 479

  Fly   449 KREEYSFMAAEASVVKQWLQATHKIIEIARNEHARRNTFSLPM 491
            :..|..|...|  :.|:|::.....|.....|:|..|.....|
Human   480 QGYELFFKTRE--LKKKWMEQFEMAISNIYPENATANGHDFQM 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15611	NP_611189.2	RhoGEF	167..313	CDD:470622	34/173 (20%)
VAV1	NP_005419.2	CH_VAV1	2..121	CDD:409111	7/28 (25%)
		RhoGEF	195..371	CDD:238091	39/202 (19%)
		PH_Vav	385..508	CDD:269930	27/147 (18%)
		C1_VAV1	510..566	CDD:410417	3/11 (27%)
		SH3_VAV1_1	596..658	CDD:212912
		SH2_Vav1	665..767	CDD:198268
		SH3_VAV1_2	786..839	CDD:212909