Protein Alignment CG15611 and PLEKHG2

DIOPT Version :10

• Sequence 1: NP_611189.2
• Gene: CG15611 / 36930
• FlyBaseID: FBgn0034194
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_073746.2
• Gene: PLEKHG2 / 64857
• HGNCID: 29515
• Length: 1386
• Species: Homo sapiens
• Alignment Length: 449
• Identity: 105/449 - (23%)
• Similarity: 172/449 - (38%)
• Gaps: 115/449 - (25%)

  Fly    96 GISLSSIN----------------TCSTTAANSSPTYRAPNGFHSFPSHTLSFETLGDEYHEDED 144
            |:|||..:                .|.|..|.::||..:|.|..|    :.|..|:|.|......
Human     7 GLSLSKPSPSLGCGRRGEVCDCGTVCETRTAPAAPTMASPRGSGS----STSLSTVGSEGDPAPG 67

  Fly   145 -----TLSLENLFPCDQTEIYAS----------KKISFIIDELIQTEVNYVNNLKKGMLNY-GQL 193
                 :.|.....|.....::.|          .::..:..|:::||..||.:|:..:.:| |.|
Human    68 PTPACSASRPEPLPGPPIRLHLSPVGIPGSARPSRLERVAREIVETERAYVRDLRSIVEDYLGPL 132

  Fly   194 KDVEDLPEALSGETKQKMLLGNIKEILELHEKEILPLMLRNQRDLKGLFDEFAAHFEKNSFYCYV 258
            .|...|  .||.| :...|..||::|.|. ..|:|. .|.|.....|:.:.|....|  .|..|.
Human   133 LDGGVL--GLSVE-QVGTLFANIEDIYEF-SSELLE-DLENSSSAGGIAECFVQRSE--DFDIYT 190

  Fly   259 SFTMGKKSSMQLRQD------NRLWLQTYQTQIKDKLGIDSFLVQPIQRLTRYPLLLQQFISEFY 317
            .:.|...||:.|.::      ..||||..|.|::..|.:.|||::|:||:.:|.||||: :.:.:
Human   191 LYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQE-LGKHW 254

  Fly   318 KSG-------------ISCKPVLTAVCKLETRMRRALDVVNQAEEI---------PNIEELNELD 360
            ..|             :|    :|||......|:|..:...:.:|:         |.:....||
Human   255 AEGPGTGGREMVEEAIVS----MTAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSAFGEL- 314

  Fly   361 VLQLGNFRRATEFDAQHFPTRKKYRSKVFLFDRCLVCTEVRKKRLAYRQHYNWEHVELQRPLDSV 425
            ||: |.||..    ....|..:.....:|||.|.|:..:.|.....|:.|.
Human   315 VLE-GAFRGG----GGGGPRLRGGERLLFLFSRMLLVAKRRGLEYTYKGHI-------------- 360

  Fly   426 SSNANKIINLLVKQEEGGSSVGSKREEYSFMAAEASVVKQWLQATHKIIEIARNEHARR 484
                 ...||.|.:        |.|:...|..::.::.|      |:.:..|:|:..:|
Human   361 -----FCCNLSVSE--------SPRDPLGFKVSDLTIPK------HRHLLQAKNQEEKR 400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15611	NP_611189.2	RhoGEF	167..313	CDD:470622	50/152 (33%)
PLEKHG2	NP_073746.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		4/13 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..82		11/49 (22%)
		RhoGEF	106..281	CDD:459876	55/186 (30%)
		PH_PLEKHG1_G2_G3	263..413	CDD:270063	35/181 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	436..540
		PHA03247	<443..904	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	554..612
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	701..739
		Atrophin-1	769..>1153	CDD:460830
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	790..815
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	829..859
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1037..1099
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1162..1191
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1291..1333
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1367..1386