Protein Alignment CG15611 and PLEKHG1

DIOPT Version :10

• Sequence 1: NP_611189.2
• Gene: CG15611 / 36930
• FlyBaseID: FBgn0034194
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_001316727.1
• Gene: PLEKHG1 / 57480
• HGNCID: 20884
• Length: 1444
• Species: Homo sapiens
• Alignment Length: 581
• Identity: 117/581 - (20%)
• Similarity: 213/581 - (36%)
• Gaps: 157/581 - (27%)

  Fly    60 LESQSPSSPIATTLPKSQASSNGKLE-KQISLLDSDSGISLSSINTCSTTAANSSPTYRAPNGFH 123
            |..:.||:......||:.|..:...| |.:.|.|||..:|..|        .:||.:.|..:|
Human    31 LRLEVPSAVTKVPHPKTTARRSCPQELKTMELSDSDRPVSFGS--------TSSSASSRDSHG-- 85

  Fly   124 SFPSH-TLSFETLGDEYHEDEDT----LSLENLFPCDQTEIY----------------------- 160
            ||.|. ||...:....:::|::.    |.|....|...:|:.
Human    86 SFGSRMTLVSNSHMGLFNQDKEVGAIKLELIPARPFSSSELQRDNPATGQQNADEGSERPPRAQW 150

  Fly   161 ---------------ASKKISF---IIDELIQTEVNYVNNLKKGMLNYGQLKDVEDLPEALSGET 207
                           .|.|:.:   ::.|:::||..||.:||..:.:|  |..:.|..:...|..
Human   151 RVDSNGAPKTIADSATSPKLLYVDRVVQEILETERTYVQDLKSIVEDY--LDCIRDQTKLPLGTE 213

  Fly   208 KQKMLLGNIKEILELHEKEILPLMLRNQRDLKGLFDEFAAHFEKNSFYCYVSFTMGKKSSMQLRQ 272
            ::..|.|||::|...: .|:|..:...:.|...:.:.|.:..|:  |:.|..:......|:.:..
Human   214 ERSALFGNIQDIYHFN-SELLQDLENCENDPVAIAECFVSKSEE--FHIYTQYCTNYPRSVAVLT 275

  Fly   273 D---NRL---WLQTYQTQIKDKLGIDSFLVQPIQRLTRYPLLLQQFISEFYKSGISCKPVLTAVC 331
            :   |::   :.:..|..:|..|.:.|:|::|:||:.:|.|||.:..:...|.......||.|:.
Human   276 ECMRNKILAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAID 340

  Fly   332 KLETRMRRALDVVNQAEEIPNIEELNEL-------DVLQLGNFRRATEFDAQHFPTRKKYRSKVF 389
            .::.......|:..:.|....::|:..|       |:...|.......|..|    |.|....:|
Human   341 TMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQ----RAKNERTLF 401

  Fly   390 LFDRCLVCTEVRKKRLAYRQH---------------------YNWEHVELQRPLDSVSSNANKII 433
            |||:.|:.|:.|.....|:.|                     :::::.:||..:.:.|....::.
Human   402 LFDKLLLITKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLW 466

  Fly   434 NLLVKQ--------------------------------EEGGSSV--GSK----------REEYS 454
            .|.:|:                                .|||:..  |||          :.|.|
Human   467 VLHLKRLILENHAAKIPAKAKQAILEMDAIHHPGFCYSPEGGTKALFGSKEGSAPYRLRRKSEPS 531

  Fly   455 FMAAEASVVKQWLQATHKI--------IEIARNEHARRNT--FSLPMDLVL---GVVLAIW 502
            ..:.:.....:..|...|:        :..||...|:||:  .|..|..||   |.:..||
Human   532 SRSHKVLKTSETAQDIQKVSREEGSPQLSSARPSPAQRNSQPSSSTMISVLRAGGALRNIW 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15611	NP_611189.2	RhoGEF	167..313	CDD:470622	37/154 (24%)
PLEKHG1	NP_001316727.1	RhoGEF	176..350	CDD:459876	41/178 (23%)
		PH_PLEKHG1_G2_G3	332..477	CDD:270063	27/148 (18%)