Protein Alignment CG15611 and Kalrn

DIOPT Version :10

• Sequence 1: NP_611189.2
• Gene: CG15611 / 36930
• FlyBaseID: FBgn0034194
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: XP_011244253.1
• Gene: Kalrn / 545156
• MGIID: 2685385
• Length: 2999
• Species: Mus musculus
• Alignment Length: 474
• Identity: 111/474 - (23%)
• Similarity: 204/474 - (43%)
• Gaps: 74/474 - (15%)

  Fly    41 DNGKSIDVVDKAPAKE-CPLLESQSPSSPIATTLPKSQASSNGKLEKQISLLDSDSGISLSSINT 104
            |..||.|:....|..| .|..:|....|.......:....|:..|...:.:.|:|.    :....
Mouse  1802 DGRKSFDLGSPKPGDETTPQGDSADEKSKKGWGEDEPDEESHTPLPPPMKIFDNDP----TQDEM 1862

  Fly   105 CSTTAANSSPTYRAP------NGFHSFPSHTLSFETLGDEYH---EDEDTLSLENLFPC------ 154
            .|..||..:|. ..|      :.......:.|:.|  |..|.   :|......|.:.|.
Mouse  1863 SSLLAARQAPP-DVPTAADLVSAIEKLVKNKLTLE--GGSYRGSLKDPTGCLNEGMTPPTPPRNL 1924

  Fly   155 -DQTEIYASKKISFIIDELIQTEVNYVNNLKKGMLNYGQLKDVED--LPEALSGETKQKMLLGNI 216
             ::.:..|.:...|:::||:|||.:||.:|  |::..|.:|.:|:  :||.:.|  |:|::.|||
Mouse  1925 EEEQKAKALRGRMFVLNELVQTEKDYVKDL--GIVVEGFMKRIEEKGVPEDMRG--KEKIVFGNI 1985

  Fly   217 KEILELHEKEILPLMLRNQRDLKGLFDEFAAHFEKNSFYCYVSFTMGKKSSMQLRQDNRLWLQTY 281
            .:|.:.|:...|..:.:..::...|...|..|..|  .:.||.:...|..|..:..:...:.:..
Mouse  1986 HQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERK--LHIYVWYCQNKPRSEYIVAEYDAYFEEV 2048

  Fly   282 QTQIKDKLGIDSFLVQPIQRLTRYPLLLQQFISEFYKSGISCKPVLTAV---CKLETRMRRALDV 343
            :.:|..:|.:..||::||||:|:|.|||:.|:....|:|:.|..:..||   |.:..|
Mouse  2049 KQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKR------- 2106

  Fly   344 VNQAEEIPNIEELNELD--------VLQLGNFRRATEFDAQHFPTRKKYRSKVFLFDRCLVCTE- 399
               ..::.|:..|...:        :||...| ...|.|| ...:|.|.| :||||::.::.:|
Mouse  2107 ---CNDMMNLGRLQGFEGTLTAQGKLLQQDTF-YVIELDA-GMQSRTKER-RVFLFEQIVIFSEL 2165

  Fly   400 VRKKRLA----YRQHYNWEHVELQRPLDSVSSNANKIINLLVKQEEGGSSVGSKREEYSFMAAEA 460
            :||..|.    :::.....::.|:   |:|..:..|.  .|:.:|..        |.....||.:
Mouse  2166 LRKGSLTPGYMFKRSIKMNYLVLE---DNVDGDPCKF--ALMNRETS--------ERVILQAANS 2217

  Fly   461 SVVKQWLQATHKIIEIARN 479
            .:.:.|:|..::::|..|:
Mouse  2218 DIQQAWVQDINQVLETQRD 2236

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15611	NP_611189.2	RhoGEF	167..313	CDD:470622	45/147 (31%)
Kalrn	XP_011244253.1	PH1_Kalirin_Trio_like	1469..1591	CDD:270060
		SH3_Kalirin_1	1657..1716	CDD:212786
		SH3-RhoG_link	1714..1896	CDD:465196	19/98 (19%)
		RhoGEF	1939..2108	CDD:459876	52/184 (28%)
		PH2_Kalirin_Trio_p63RhoGEF	2113..2247	CDD:270061	31/140 (22%)
		SH3_Kalirin_2	2331..2387	CDD:212787
		I-set	2478..2572	CDD:400151
		Ig strand B	2495..2499	CDD:409353
		Ig strand C	2508..2512	CDD:409353
		Ig strand E	2538..2542	CDD:409353
		Ig strand F	2552..2557	CDD:409353
		Ig strand G	2565..2568	CDD:409353
		FN3	2576..2667	CDD:238020
		STKc_Kalirin_C	2697..2944	CDD:271017
		SEC14	47..185	CDD:214706
		SPEC	198..418	CDD:238103
		SPEC	319..544	CDD:238103
		SPEC	545..774	CDD:238103
		SPEC	899..1137	CDD:238103
		SPEC	1143..1243	CDD:197544
		RhoGEF	1292..1462	CDD:238091