DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG15611 and Arhgef25

DIOPT Version :10

Sequence 1:NP_611189.2 Gene:CG15611 / 36930 FlyBaseID:FBgn0034194 Length:508 Species:Drosophila melanogaster
Sequence 2:NP_082303.2 Gene:Arhgef25 / 52666 MGIID:1277173 Length:618 Species:Mus musculus


Alignment Length:544 Identity:111/544 - (20%)
Similarity:209/544 - (38%) Gaps:157/544 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 PAKECPLLESQSPSSPIATTLPKS--QASSNGKLEKQI----------SLLDSDSGISLSSINTC 105
            |.:|.|  ..:.|..|.:|.....  :....|:.|.::          |:..|:..:|.|::   
Mouse    29 PGQEGP--PERDPLGPGSTKTESDCIEEDQTGQREPEVLAWAPQPESYSIAVSEGSMSASAV--- 88

  Fly   106 STTAANSSPTYRAPNGFHSFP-------------------SHTLSFE------------------ 133
            |..||.|.|:    :|..|.|                   .|.||.|                  
Mouse    89 SGLAALSGPS----SGLSSDPCSPIPPGPVTGLRRWLDHSKHCLSVETEAESGQTGQCENWTLEP 149

  Fly   134 --TLGDEYHE------------------DEDTLSLENLFPCDQTEIYASKKIS-----FIIDELI 173
              |.|.|..|                  :|:|||..   |.::.|   .||::     |::.||:
Mouse   150 TLTTGQELPELTLLTTLLEGPGDKAQPAEEETLSQA---PKNEEE---QKKMALERSMFVLGELV 208

  Fly   174 QTEVNYVNNLKKGMLNYGQLKDVEDLPEALSGETKQKMLLGNIKEILELHEKEILPLMLRNQRDL 238
            :||..||::|.:.:..|......:.:||:|.|  :.:::.|||::|.|.|....|..:.:..:|.
Mouse   209 ETERTYVDDLGQIVEGYMATMATQGVPESLRG--RDRIVFGNIQQIYEWHRDYFLQELQQCLKDP 271

  Fly   239 KGLFDEFAAHFEKNSFYCYVSFTMGK-KSSMQLRQDNRLWLQTYQTQIKDKLGIDSFLVQPIQRL 302
            ..|...|..|  :...:.||.:...| ||...|.:....:.:..:.|:..:|.::..|::|:||:
Mouse   272 DWLAQLFIKH--ERRLHMYVVYCQNKPKSEHVLSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRI 334

  Fly   303 TRYPLLLQQFISEFYKSGISCKPVLTAVCKLETRMRRALDVVNQAEEIPNIEELNELDVLQLGNF 367
            .:|.|||:.|:..:.::|           |....:.:|::|:....:..|       |::.||..
Mouse   335 MKYQLLLKDFLKYYRRAG-----------KDTEELEQAVEVMCFVPKRCN-------DMMSLGRL 381

  Fly   368 R------------------RATEFDAQHFPTRKKYRSKVFLFDRCLVCTEV--------RKKRLA 406
            |                  ..||.:|....:.:....:||||::.::.:|.        .:....
Mouse   382 RGFEGKLTAQGKLLGQDTFLVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGGRGGAQPGYV 446

  Fly   407 YRQHYNWEHVELQRPLDSVSSNANKIINLLVKQEEGGSSVGSKREEYSFMAAEASVVKQWLQATH 471
            |:.......:.|:   .::..|..:.. |..:..|||.      :.|...|::.:|.:.|::...
Mouse   447 YKNSIKVSCLGLE---GNLQGNPCRFA-LTSRGPEGGI------QRYVLQASDPAVSQAWIKQVA 501

  Fly   472 KIIEIARN---------EHARRNT 486
            :|:|..|:         |:.||.:
Mouse   502 QILESQRDFLNALQSPIEYQRRES 525

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG15611NP_611189.2 RhoGEF 167..313 CDD:470622 40/146 (27%)
Arhgef25NP_082303.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..63 8/35 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 169..193 6/29 (21%)
RhoGEF 203..373 CDD:459876 44/184 (24%)
Important for binding to Rho GTPases. /evidence=ECO:0000250 317..338 5/20 (25%)
PH2_Kalirin_Trio_p63RhoGEF 378..520 CDD:270061 25/151 (17%)
Sufficient to bind activated GNAQ. /evidence=ECO:0000250 506..532 4/20 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 521..556 2/5 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 584..604
Blue background indicates that the domain is not in the aligned region.

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