DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG15611 and trio

DIOPT Version :10

Sequence 1:NP_611189.2 Gene:CG15611 / 36930 FlyBaseID:FBgn0034194 Length:508 Species:Drosophila melanogaster
Sequence 2:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster


Alignment Length:496 Identity:113/496 - (22%)
Similarity:204/496 - (41%) Gaps:137/496 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    83 KLEKQIS------LLDSDSGISLSSINTCSTTAANSSPTYRAPNGFHSFPSHTLSFETLGDEYHE 141
            :|||.:.      ||.||...|:||    |:...:|.||..|               .|.....|
  Fly  1224 QLEKSLGMSQQQLLLGSDGNSSISS----SSGDRHSDPTLEA---------------KLNSSNKE 1269

  Fly   142 DEDTLSLENLFPCDQTEIYASKKISFIIDELIQTEVNYVNNLK---KGMLNYGQLKDVEDLPEAL 203
            :::         .::.:..::::..||:.||:|||..|||:|.   |..|.  :.:..:.:|.||
  Fly  1270 NKE---------INEEKRKSARRKEFIMAELMQTERAYVNDLATCIKCFLE--EFRAGKSVPSAL 1323

  Fly   204 SGETKQKMLLGNIKEILELHEK---------EILPLMLRNQRDLKGLFDEFAAHFEKNSFYCYVS 259
            .|:  :.::.||||||...|:|         |.:|      .|:...|..:|:.|:     .||.
  Fly  1324 IGQ--EDVIFGNIKEIHHFHQKIFLRELEKYETMP------EDVGHCFVTWASKFD-----MYVH 1375

  Fly   260 FTMGKKSSMQLRQDNRLWLQ---TYQTQIKDKLGID----SFLVQPIQRLTRYPLLLQQFISEFY 317
            :...|.:|      |.|.:|   ::..:::.:|.:|    ::|::|:||:|:|.|||:..:|...
  Fly  1376 YCKNKPTS------NNLLVQHGGSFFEELQRRLEVDHPLPAYLIKPVQRITKYQLLLKDLLSCCE 1434

  Fly   318 KSGISCKPVLTAVCKLETRMRRALDVVNQAEEIPNIEELNELDVL--QLGNFRRATEFDAQHFPT 380
            :|....|..|..:          |:|..:|.:..::..|...||.  :||.......|.|  :.|
  Fly  1435 ESHGEIKEGLEVM----------LNVPKKANDAMHLSLLENCDVSVDKLGEVVLQDAFQA--WDT 1487

  Fly   381 ----RKKYRSKVFLFDRCLV-CTEVRKKRLAYRQHYN---------WEHVELQRPLDSVSSNANK 431
                ||....:||||:..|: ..||::..:...|..:         .||:|......:|.:..:.
  Fly  1488 KQIIRKGRERRVFLFELYLLFAKEVKESNVVKYQFKSKLMTTDMGITEHIEGDETKFAVWTGRSP 1552

  Fly   432 IIN---LLVKQEEGGSSVGSKR----------EEYSFMAAEASVVKQWLQATHK----------I 473
            :::   :::|    .:|:.:|:          :|..|.....::.|.  .|.|.          .
  Fly  1553 MLSDCRIVLK----ATSLETKQIWVKKLREVMQETCFSGTSLTLPKS--PAKHSGSSQRSSRDLD 1611

  Fly   474 IEIARNEHARRNTFSL------PMDLVLGVVLAIWLIWQYL 508
            .::..|:|.|.:..|.      ..|..||...|.|::..|:
  Fly  1612 EQLTENDHDRCSLASFGSGNTTDSDNKLGNQEATWVVADYI 1652

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG15611NP_611189.2 RhoGEF 167..313 CDD:470622 49/164 (30%)
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103
SPEC 782..997 CDD:238103
SPEC 897..1119 CDD:238103
SPEC 1125..1226 CDD:197544 0/1 (0%)
RhoGEF 1287..1455 CDD:459876 54/198 (27%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 26/127 (20%)
SH3_Kalirin_1 1643..1707 CDD:212786 3/10 (30%)
RhoGEF 1945..2121 CDD:459876
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
Blue background indicates that the domain is not in the aligned region.

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