Protein Alignment CG15611 and Arhgef25

DIOPT Version :10

• Sequence 1: NP_611189.2
• Gene: CG15611 / 36930
• FlyBaseID: FBgn0034194
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_001387885.1
• Gene: Arhgef25 / 314904
• RGDID: 735210
• Length: 613
• Species: Rattus norvegicus
• Alignment Length: 547
• Identity: 112/547 - (20%)
• Similarity: 209/547 - (38%)
• Gaps: 163/547 - (29%)

  Fly    53 PAKECPLLESQSPSSPIATTLPK--SQASSNGKLEKQI----------SLLDSDSGISLSSINTC 105
            |.:|.|  :.:.|..|.:|....  ::....|:.|:::          |:..|:..:|.|::
  Rat    29 PGQEGP--QERDPLGPGSTKTESECTEEDQTGEREREVLAWAPQPESYSIAGSEGSMSASAV--- 88

  Fly   106 STTAANSSPTYRAPNGFHSFP-------------------SHTLSFE------------------ 133
            |..||.|.|:    :|..|.|                   .|.||.|
  Rat    89 SGLAALSGPS----SGLSSHPCSPVPPGPVTGLRRWLDHSKHCLSVETEADSGQTRQCENWMLEP 149

  Fly   134 --TLGDEYHE------------------DEDTLSLENLFPCDQTEIYASKKIS-----FIIDELI 173
              |.|.|..|                  :|:|||..   |.::.|   .||.:     |::.||:
  Rat   150 TLTTGQELPELTLLTTLLEGPGVKAQPAEEETLSQA---PKNEEE---QKKTALERSMFVLSELV 208

  Fly   174 QTEVNYVNNLKKGMLNYGQLKDVEDLPEALSGETKQKMLLGNIKEILELHEKEILPLMLRNQRDL 238
            :||..||::|.:.:..|......:.:||:|.|  :.:::.|||::|.|.|....|..:.:..:|.
  Rat   209 ETERMYVDDLGQIVEGYMATMATQGVPESLRG--RDRIVFGNIQQIYEWHRDYFLQELQQCLKDP 271

  Fly   239 KGLFDEFAAHFEKNSFYCYVSFTMGK-KSSMQLRQDNRLWLQTYQTQIKDKLGIDSFLVQPIQRL 302
            ..|...|..|  :...:.||.:...| ||...|.:....:.:..:.|:..:|.:...|::|:||:
  Rat   272 DWLAQLFIKH--ERRLHMYVVYCQNKPKSEHVLSEFGDSYFEELRQQLGHRLQLSDLLIKPVQRI 334

  Fly   303 TRYPLLLQQFISEFYKSGISCKPVLTAV---CKLETRMRRALDVVNQAEEIPNIEELNELDVLQL 364
            .:|.|||:.|:..:.::|:..:.:..||   |.:..|..                     |::.|
  Rat   335 MKYQLLLKDFLKYYRRAGMDTEELEQAVEVMCFVPKRCN---------------------DMMSL 378

  Fly   365 GNFR------------------RATEFDAQHFPTRKKYRSKVFLFDRCLVCTEV--------RKK 403
            |..|                  ..||.:|....:.:....:||||::.::.:|.        .:.
  Rat   379 GRLRGFEGKLTAQGKLLGQDTFLVTEPEAGGLLSSRGRERRVFLFEQIVIFSEALGGGGRGGTQP 443

  Fly   404 RLAYRQHYNWEHVELQRPLDSVSSNANKIINLLVKQEEGGSSVGSKREEYSFMAAEASVVKQWLQ 468
            ...|:.......:.|:   .::..||.:.. |..:..|||.      :.|...|::.:|.:.|::
  Rat   444 GYVYKNSIKVSCLGLE---GNLQGNACRFA-LTSRGPEGGI------QRYVLQASDPAVSQAWIK 498

  Fly   469 ATHKIIEIARN---------EHARRNT 486
            ...:|:|..|:         |:.||.:
  Rat   499 QVAQILESQRDFLNALQSPIEYQRRES 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15611	NP_611189.2	RhoGEF	167..313	CDD:470622	40/146 (27%)
Arhgef25	NP_001387885.1	RhoGEF	203..373	CDD:459876	45/173 (26%)
		PH2_Kalirin_Trio_p63RhoGEF	378..520	CDD:270061	26/151 (17%)