Protein Alignment CG15611 and Trio

DIOPT Version :10

• Sequence 1: NP_611189.2
• Gene: CG15611 / 36930
• FlyBaseID: FBgn0034194
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_001101128.3
• Gene: Trio / 310192
• RGDID: 1308360
• Length: 3103
• Species: Rattus norvegicus
• Alignment Length: 524
• Identity: 110/524 - (20%)
• Similarity: 213/524 - (40%)
• Gaps: 117/524 - (22%)

  Fly    39 NADNGKSIDVVDKAPAKECPLLESQSPSSPIAT-TLPKSQAS---SNGKLE-------------- 85
            :||.|...|..|.|...:...:|.:..:..::: ||.||.:|   |.|:.|
  Rat  1809 SADAGSQKDSDDSAATPQDETIEERGRNEGLSSGTLSKSSSSGMQSCGEEEGEEGADAVPLPPPM 1873

  Fly    86 --KQISLLDSDSGISLSSINTCSTTAANSSPT-----------YRAPNGFHSFPSHTLSFETLGD 137
              :|.|||..||....:|........::.:|:           .::.......||..|..:  ||
  Rat  1874 AIQQHSLLQPDSQDDKASSRLLVRPTSSETPSAAELVSAIEELVKSKMALEDRPSSLLVDQ--GD 1936

  Fly   138 ----EYHEDEDTLSLENLFPCDQTE---IYASKKISFIIDELIQTEVNYVNNLKKGMLNYGQLKD 195
                .::..:::| |.:..|.|:.|   ..:.|:..:::.||::||.:||.:|...:..|..|..
  Rat  1937 SSSPSFNPSDNSL-LSSSSPIDEMEERKCSSLKRRHYVLQELVETERDYVRDLGCVVEGYMALMK 2000

  Fly   196 VEDLPEALSGETKQKMLLGNIKEILELHEKEILPLMLRNQRDLKGLFDEFAAHFEKNSFYCYVSF 260
            .:.:|:.:.|  |.|::.|||.:|.:.|....|..:.:...|.:.|...|..|  :...:.|:.:
  Rat  2001 EDGVPDDMKG--KDKIVFGNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKH--ERRLHMYIVY 2061

  Fly   261 TMGKKSSMQLRQDNRLWLQTYQTQIKDKLG----IDSFLVQPIQRLTRYPLLLQQFISEFYKSGI 321
            ...|..|..:..:   ::.|:...:|.:||    :...|::|:||:.:|.|||:.|:....|:.:
  Rat  2062 CQNKPKSEHIVSE---YIDTFFEDLKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASL 2123

  Fly   322 SCKPVLTAVCKLETRMRRALDVV----NQAEEIPNIEELNELD-------VLQLGNFRRATEFDA 375
            .           .:.:.:|::|:    .:..::.|:..|...|       .|.|.:....|:.||
  Rat  2124 D-----------TSELEKAVEVMCIVPKRCNDMMNVGRLQGFDGKIVAQGKLLLQDTFLVTDQDA 2177

  Fly   376 QHFPTRKKYRSKVFLFDRCLVCTEVRKKRLAYRQHYNWEHVELQRPLDS---------VSSNANK 431
            ...|..|:.|  ||||::.::.:|                     |||.         :..|:.|
  Rat  2178 GLLPRCKERR--VFLFEQIVIFSE---------------------PLDKKKGFSMPGFLFKNSIK 2219

  Fly   432 IINLLVKQEEGG--------SSVGSKREEYSFMAAEASVVKQWLQATHKIIEIARNEHARRNTFS 488
            :..|.:::....        |..|...|.:...::..||.:.|:   |:|.:|..|:....|..:
  Rat  2220 VSCLCLEENVESDPCKFALTSRTGDAVETFILHSSSPSVRQTWI---HEINQILENQRNFLNALT 2281

  Fly   489 LPMD 492
            .|::
  Rat  2282 SPIE 2285

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15611	NP_611189.2	RhoGEF	167..313	CDD:470622	38/149 (26%)
Trio	NP_001101128.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27
		SEC14	69..204	CDD:214706
		SPEC	227..445	CDD:238103
		Spectrin 1	311..418
		SPEC	341..566	CDD:238103
		Spectrin 2	538..644
		SPEC	567..783	CDD:238103
		SPEC	787..1014	CDD:238103
		Spectrin 3	878..984
		SPEC	908..1137	CDD:238103
		Spectrin 4	1109..1216
		SPEC	1143..1243	CDD:197544
		RhoGEF	1295..1465	CDD:238091
		PH1_Kalirin_Trio_like	1472..1594	CDD:270060
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1601..1651
		SH3_Kalirin_1	1659..1718	CDD:212786
		SH3-RhoG_link	1715..1972	CDD:465196	34/165 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1738..1907		23/97 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1927..1956		7/31 (23%)
		RhoGEF	1970..2143	CDD:238091	42/190 (22%)
		PH2_Kalirin_Trio_p63RhoGEF	2148..2286	CDD:270061	33/164 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2287..2556
		SH3_Kalirin_2	2559..2617	CDD:212787
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2643..2667
		I-set	2689..2780	CDD:400151
		Ig strand B	2706..2710	CDD:409570
		Ig strand C	2719..2730	CDD:409570
		Ig strand E	2746..2750	CDD:409570
		Ig strand F	2760..2765	CDD:409570
		Ig strand G	2773..2776	CDD:409570
		STKc_Trio_C	2792..3054	CDD:271015