DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG15611 and PLEKHG4

DIOPT Version :10

Sequence 1:NP_611189.2 Gene:CG15611 / 36930 FlyBaseID:FBgn0034194 Length:508 Species:Drosophila melanogaster
Sequence 2:NP_001123199.1 Gene:PLEKHG4 / 25894 HGNCID:24501 Length:1191 Species:Homo sapiens


Alignment Length:458 Identity:94/458 - (20%)
Similarity:163/458 - (35%) Gaps:128/458 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 LLESQSPSSPIATTLPKSQASSNGKLEKQISLLDSDSGISLS----------SINTCSTTAA--- 110
            |..||.|::|....|.|:.:            .|.:.|.|||          :|..|....|   
Human   658 LCVSQVPAAPAHPPLRKAYS------------FDRNLGQSLSEPACHCHHAATIAACRRPEAGGG 710

  Fly   111 ---NSSPTYRAPNGFHSFPSHTLSFETLGDEYHEDEDTLSLENLFPCDQTEIYASKKISFIIDEL 172
               .:|||...|.                     ..|..||              .::..::.|:
Human   711 ALPQASPTVPPPG---------------------SSDPRSL--------------NRLQLVLAEM 740

  Fly   173 IQTEVNYVNNLKKGMLNYGQLKDVEDLPEALSGETKQKMLLGNIKEILELHEKEILPLMLRNQRD 237
            :.||..||..|:..|.||....|..|:|:.|.|:  :..|.||::::.:.|....|..:....|.
Human   741 VATEREYVRALEYTMENYFPELDRPDVPQGLRGQ--RAHLFGNLEKLRDFHCHFFLRELEACTRH 803

  Fly   238 LKGLFDEFAAHFEKNSFYCYVSFTMGK-KSSMQLRQDNRLWLQTYQTQIKDKLGIDSFLVQPIQR 301
            ...:...|..|  :..|..|..::..| :|...:......:.:..|..:.|.|.:.|:|::||||
Human   804 PPRVAYAFLRH--RVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQQALGDHLDLASYLLKPIQR 866

  Fly   302 LTRYPLLLQQFISEFYKSGISCKPVLTAVCKLETRMRRALDVVNQAEEIPNIE-----ELNELDV 361
            :.:|.||||:               |...|...|   :.|..:.:|:.:.:.:     :|..:|.
Human   867 MGKYALLLQE---------------LARACGGPT---QELSALREAQSLVHFQLRHGNDLLAMDA 913

  Fly   362 LQ--------LGNFRRATEFDAQHFPTRKKYRSKVFLFDRCLVCTEVRK-----KRLAYRQHYNW 413
            :|        .|...|..||..:  ..|.|...::|||:..|:.::.|.     ...||::.:..
Human   914 IQGCDVNLKEQGQLVRQDEFVVR--TGRHKSVRRIFLFEELLLFSKPRHGPTGVDTFAYKRSFKM 976

  Fly   414 EHVELQRPLDSVSSNANKIINLLVKQEEGGSSVGSKREEYSFMAAEASVVKQ----------WLQ 468
            ..:    .|.....|:|....:..::.        |..:...:.|.:..:||          |.|
Human   977 ADL----GLTECCGNSNLRFEIWFRRR--------KARDTFVLQASSLAIKQAWTADISHLLWRQ 1029

  Fly   469 ATH 471
            |.|
Human  1030 AVH 1032

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG15611NP_611189.2 RhoGEF 167..313 CDD:470622 40/146 (27%)
PLEKHG4NP_001123199.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..152
SEC14 193..321 CDD:469559
SPEC 447..>598 CDD:413338
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 707..728 6/41 (15%)
RhoGEF 736..898 CDD:459876 45/183 (25%)
PH_puratrophin-1 899..1034 CDD:270062 27/148 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1150..1176
Blue background indicates that the domain is not in the aligned region.

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