Protein Alignment CG15611 and ARHGEF9

DIOPT Version :10

• Sequence 1: NP_611189.2
• Gene: CG15611 / 36930
• FlyBaseID: FBgn0034194
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_001340852.1
• Gene: ARHGEF9 / 23229
• HGNCID: 14561
• Length: 529
• Species: Homo sapiens
• Alignment Length: 512
• Identity: 115/512 - (22%)
• Similarity: 199/512 - (38%)
• Gaps: 160/512 - (31%)

  Fly    69 IATTLPKSQASSNGKLEKQISLLDSDSGISLSSINTCSTTAANSSPTYRA--------------- 118
            :|...|.:.|.|.       ||:..||.:|..:: ....|.||....::|
Human     3 VALAAPHASARSR-------SLITGDSIVSAEAV-WDHVTMANRELAFKAGDVIKVLDASNKDWW 59

  Fly   119 ------PNGFHSFPSHTLSFETL----GDEYHEDEDTLSLENLFP-----C------DQTEIYAS 162
                  ..|:  ||:   ||..|    .||..|....:...:|.|     |      ::.::.|:
Human    60 WGQIDDEEGW--FPA---SFVRLWVNQEDEVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRAN 119

  Fly   163 KKISFIIDELIQTEVNYVNNLKKGMLNYGQLKDVEDLPEALSGETKQKMLLGNIKEILEL----- 222
                 :|:|::.||.:|:.:||.  :..|.||......:..|.| :.|::.|||::|...
Human   120 -----VINEIMSTERHYIKHLKD--ICEGYLKQCRKRRDMFSDE-QLKVIFGNIEDIYRFQMGFV 176

  Fly   223 ------------HEKEILPLMLRNQRDLKGLFDEFAAHFEKNSFYCYVSFTMGKKSSMQLRQDNR 275
                        |..||.|..|.:|       |.|..:.|    ||........:.| :|.:|:|
Human   177 RDLEKQYNNDDPHLSEIGPCFLEHQ-------DGFWIYSE----YCNNHLDACMELS-KLMKDSR 229

  Fly   276 LWLQTYQ---------TQIKDKLGIDSFLVQPIQRLTRYPLLLQQFISEFYKSGISCKPVLTAVC 331
                 ||         .|:.| :.||.||:.|:|::.:|||.|.:.:....:.....:.|..|:.
Human   230 -----YQHFFEACRLLQQMID-IAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALA 288

  Fly   332 KLETRMRRALDVVNQAE-EIPNIEELNEL----------DVLQLGNFRRATE--FDAQ----HFP 379
            .    ||.....:|:.: .:.||:::.:.          |:|.     |::|  :..:    :.|
Human   289 V----MRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILD-----RSSELIYTGEMAWIYQP 344

  Fly   380 TRKKYRSKVFLFDRCLV-CTE--VRKKRLAYRQHYN---WEHVELQRPLD---SVS-SNANKIIN 434
            ..:..:...||||..:| |.:  :|:..|.|:...:   :|.|:::...|   :|| .||.|:.|
Human   345 YGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHN 409

  Fly   435 LLVKQEEGGSSVGSKREEYSFMAAEASVVKQWLQA----------THKI-IEIARNE 480
               |:.|         |.:.|.|.:.....:||:|          ..|| .||:.|:
Human   410 ---KETE---------EIHLFFAKKLEEKIRWLRAFREERKMVQEDEKIGFEISENQ 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15611	NP_611189.2	RhoGEF	167..313	CDD:470622	46/171 (27%)
ARHGEF9	NP_001340852.1	SH3_ARHGEF9	20..81	CDD:212908	13/66 (20%)
		RhoGEF	120..299	CDD:214619	50/203 (25%)
		PH_Collybistin_ASEF	304..443	CDD:269931	33/155 (21%)