Protein Alignment CG15611 and ARHGEF25

DIOPT Version :10

• Sequence 1: NP_611189.2
• Gene: CG15611 / 36930
• FlyBaseID: FBgn0034194
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_001104740.2
• Gene: ARHGEF25 / 115557
• HGNCID: 30275
• Length: 619
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 114/549 - (20%)
• Similarity: 205/549 - (37%)
• Gaps: 164/549 - (29%)

  Fly    55 KECPLLESQSP--SSPIAT--TLPKSQASSN------------GKLE-KQISLLDSDSGISLSSI 102
            :.|.|...:.|  .||:..  |.|:|:.:..            |.|: :..|:..|:..||.|:
Human    24 RACALPGQEGPPRRSPLGLVGTEPESERTEGDHRRDREHEVLAGALQPESYSIAGSEGSISASA- 87

  Fly   103 NTCSTTAANSSPTYRAPNGFHSFP-------------------SHTLSFET-------------- 134
              .|..||.|.|:    :|..|.|                   .|.||.||
Human    88 --ASGLAAPSGPS----SGLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVETEADSGQAGPYENWM 146

  Fly   135 ------LGDEYHE------------------DEDTLSLENLFPCDQTEIYASKKI----SFIIDE 171
                  .|:|..|                  :|:|||     ...::|....||.    .:::.|
Human   147 LEPALATGEELPELTLLTTLLEGPGDKTQPPEEETLS-----QAPESEEEQKKKALERSMYVLSE 206

  Fly   172 LIQTEVNYVNNLKKGMLNYGQLKDVEDLPEALSGETKQKMLLGNIKEILELHEKEILPLMLRNQR 236
            |::||..||::|.:.:..|......:.:||:|.|  :.:::.|||::|.|.|....|..:.|..:
Human   207 LVETEKMYVDDLGQIVEGYMATMAAQGVPESLRG--RDRIVFGNIQQIYEWHRDYFLQELQRCLK 269

  Fly   237 DLKGLFDEFAAHFEKNSFYCYVSFTMGK-KSSMQLRQDNRLWLQTYQTQIKDKLGIDSFLVQPIQ 300
            |...|...|..|  :...:.||.:...| ||...:.:....:.:..:.|:..:|.::..|::|:|
Human   270 DPDWLAQLFIKH--ERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQ 332

  Fly   301 RLTRYPLLLQQFISEFYKSGISCKPVLTAV---CKLETRMRRALDVVNQAEEIPNIEELNELDVL 362
            |:.:|.|||:.|:..:.::|:....:..||   |.:..|..                     |::
Human   333 RIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCN---------------------DMM 376

  Fly   363 QLGNFRR------------------ATEFDAQHFPTRKKYRSKVFLFDRCLVCTE-----VR--- 401
            .||..|.                  .||.:|....:.:....:||||::.::.:|     ||
Human   377 TLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGT 441

  Fly   402 KKRLAYRQHYNWEHVELQRPLDSVSSNANKIINLLVKQEEGGSSVGSKREEYSFMAAEASVVKQW 466
            :....|:.......:.|:..|......    ..|..:..|||.      :.|...||:.::.:.|
Human   442 QPGYVYKNSIKVSCLGLEGNLQGDPCR----FALTSRGPEGGI------QRYVLQAADPAISQAW 496

  Fly   467 LQATHKIIEIARN---------EHARRNT 486
            ::...:|:|..|:         |:.||.:
Human   497 IKHVAQILESQRDFLNALQSPIEYQRRES 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15611	NP_611189.2	RhoGEF	167..313	CDD:470622	39/146 (27%)
ARHGEF25	NP_001104740.2	RhoGEF	203..373	CDD:459876	45/173 (26%)
		PH2_Kalirin_Trio_p63RhoGEF	378..520	CDD:270061	27/151 (18%)