Protein Alignment CG15611 and Plekhg2

DIOPT Version :10

• Sequence 1: NP_611189.2
• Gene: CG15611 / 36930
• FlyBaseID: FBgn0034194
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: XP_006539499.1
• Gene: Plekhg2 / 101497
• MGIID: 2141874
• Length: 1366
• Species: Mus musculus
• Alignment Length: 428
• Identity: 99/428 - (23%)
• Similarity: 166/428 - (38%)
• Gaps: 117/428 - (27%)

  Fly   108 TAANSSPTYRAPNGFHSFPSHTLSFETLGDEYHED------------EDTLSLENLFPCDQTEIY 160
            |||.::.|..:|.|..|    :.|..|:|.|....            |..:.| :|.|.......
Mouse    36 TAAQAATTMASPRGSGS----STSLSTVGSEGDPSPACSASRPEPLPEPPIRL-HLLPVGIQGSV 95

  Fly   161 ASKKISFIIDELIQTEVNYVNNLKKGMLNY-GQLKDVEDLPEALSGETKQ-KMLLGNIKEILELH 223
            ...::..:..|:::||..||.:|:..:.:| |.|.|    ..||....:| ..|..||::|.|.
Mouse    96 KPSRLERVAREIVETERAYVRDLRSIVEDYLGPLMD----GRALGLNMEQVGTLFANIEDIYEF- 155

  Fly   224 EKEILPLMLRNQRDLKG---------LFDEFAAHFEKNSFYCYVSFTMGKKSSMQLRQD------ 273
            ..|:|       .||:|         .|.:.:..|:..:.||     |...||:.|.::
Mouse   156 SSELL-------EDLEGCSSAGGIAECFVQRSEDFDIYTLYC-----MNYPSSLALLRELSVSPP 208

  Fly   274 NRLWLQTYQTQIKDKLGIDSFLVQPIQRLTRYPLLLQQFISEFYKSG-------------ISCKP 325
            ..||||..|.|::..|.:.|||::|:||:.:|.||||: :.:.:..|             :|
Mouse   209 ATLWLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQE-LGKHWAEGPDSGGREMVEEAIVS--- 269

  Fly   326 VLTAVCKLETRMRRALDVVNQAEEI---------PNIEELNELDVLQLGNFRRATEFDAQHFPTR 381
             :|||......|:|..:...:.:|:         |.:....|| ||: |.||..    ....|..
Mouse   270 -MTAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSAFGEL-VLE-GTFRGG----GGGGPRL 327

  Fly   382 KKYRSKVFLFDRCLVCTEVRKKRLAYRQHYNWEHVELQRPLDSVSSNANKIINLLVKQEEGGSSV 446
            :.....:|||.|.|:..:.|.....|:.|.                   ...||.|.:
Mouse   328 RGGERLLFLFSRMLLVAKRRGPEYTYKGHI-------------------FCCNLSVSE------- 366

  Fly   447 GSKREEYSFMAAEASVVKQWLQATHKIIEIARNEHARR 484
             :.|:...|..::.::.|      |:.:..|:|:..:|
Mouse   367 -TPRDPLGFKVSDLTIPK------HRHLFQAKNQEEKR 397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15611	NP_611189.2	RhoGEF	167..313	CDD:470622	49/162 (30%)
Plekhg2	XP_006539499.1	RhoGEF	103..278	CDD:459876	54/196 (28%)
		PH_PLEKHG1_G2_G3	260..410	CDD:270063	34/181 (19%)
		PTZ00449	<351..742	CDD:185628	12/80 (15%)