Protein Alignment CG30456 and ROM2

DIOPT Version :9

• Sequence 1: NP_611188.3
• Gene: CG30456 / 36929
• FlyBaseID: FBgn0050456
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_013475.1
• Gene: ROM2 / 851086
• SGDID: S000004363
• Length: 1356
• Species: Saccharomyces cerevisiae
• Alignment Length: 863
• Identity: 158/863 - (18%)
• Similarity: 273/863 - (31%)
• Gaps: 314/863 - (36%)

  Fly    16 NLSNRNFNKRNSRRRISHQAAEQERHSSTLVSSNLESN-----DVARPVSSVSSSSSSIQLSYSV 75
            |.:|.|.|...:..::....:...:||.::.|.::..|     ::|....|.:|:|......|.:
Yeast   256 NHNNNNTNNNGAHYQVGSSNSNYPQHSHSISSRSMSLNSSTLKNIASSFQSKTSNSRKATQKYDI 320

  Fly    76 NSDT-----------DSSYRHRSLLKMHEA-------------------------------ESVG 98
            .|:.           .||..|.||..:|.:                               .||.
Yeast   321 TSNPFSDPHHHHHHHHSSNSHSSLNNVHGSGNSSSVMGSSSNIGLGLKTRVSSTSLALKRYTSVS 385

  Fly    99 GLGTESTPESPMSPQTPD--------------PALLD-VRQK---------------VHRFEAFR 133
            |....|...|.|:|.:..              ||||. |..|               |:| :||.
Yeast   386 GTSLSSPRRSSMTPLSASRPVMSASSKKPQVYPALLSRVATKFKSSIQLGEHKKDGLVYR-DAFT 449

  Fly   134 TN-----IC-FIKQERHSLKLLENR---RHPSFEDQSEDHHTPPATPPRRI-------RLPGLGS 182
            ..     || .|:....:|.||..|   ....|.|...:|....:  |..:       |..|.||
Yeast   450 GQQAVDVICAIIRTSDRNLALLFGRSLDAQKLFHDVVYEHRLRDS--PHEVYEFTDNSRFTGTGS 512

  Fly   183 RGSS------RSSSIPSFQAGIHEVRSEDEVDQISDFETDSHTAAEEYLVVDTTSEVVPSEEVAD 241
            ..:.      .:||  ||.:|.|..                           ..|.:|||...:.
Yeast   513 TNAHDPLMLLPNSS--SFNSGNHSY---------------------------PNSGMVPSSSTSS 548

  Fly   242 SKVDQ-----QQVQRSISADQSKEALTLPLKMRND------FPRNYRSTPRRKTEIIGTTNEHLV 295
            ...||     .::..|.|..|.|.    |..:.|.      ....|..|         .|.:.|.
Yeast   549 LNSDQATLTGSRLHMSSSLSQQKN----PAAIHNVNGVFTLLAECYSPT---------CTRDALC 600

  Fly   296 GKFHSVYQPKDEEEEVEIELRDKS--DKCVHPILEELIKTEEAYVNNLFTGIENYGNIFQRKDLP 358
               :|:..|:..|::..:.|:...  .:.:...|::..:.:.::.:::  ..|::.|: .:|::
Yeast   601 ---YSISCPRRLEQQARLNLKPNGGLKRNISMALDDDDEEKPSWTSSV--SKEDWENL-PKKEI- 658

  Fly   359 LGLRGKK----YDLF---GNIEQIAEFHRDEFLPMLQR--------------------------N 390
                 |:    |:::   .|..:..|..||.|:..|..                          |
Yeast   659 -----KRQEAIYEVYITEKNFVKSLEITRDTFMKTLAETNIISADIRKNFIKHVFAHINDIYSVN 718

  Fly   391 RRDLKRLFD----------------EFLQFLDQHCFY----GYVIFTMNKQKSLKLCDLYKNYFT 435
            ||.||.|.|                .|:.|.:....|    .|..:.:..|:|:      ..||.
Yeast   719 RRFLKALTDRQRSSPVVRGIGDIVLRFIPFFEPFVSYVASRPYAKYLIETQRSV------NPYFA 777

  Fly   436 SIRLERDDKL-------GINSFLVQPIQRMARYPLLLTQFINTFFKNRDIVMKPLIESCCRLEKR 493
            ..    ||.:       ||:|||.|.:.|..||.||:.:.:.:....:|   |...|...:....
Yeast   778 RF----DDDMMSSSLRHGIDSFLSQGVSRPGRYMLLVKEIMKSTDPEKD---KSDYEDLSKAMDA 835

  Fly   494 LRALLTTTNESE-----------IINDIVDCHEF-NVYYQGKFRKVNEFQVLDHK-LKRSYRSKV 545
            ||..:...:::.           :...|:..:|: |:....:.||:....:|..| |.:|..:.|
Yeast   836 LRDFMKRIDQASGAAQDRHDVKLLKQKILFKNEYVNLGLNDERRKIKHEGILSRKELSKSDGTVV 900

  Fly   546 -----FIFDKCIIYTEIKGKN---------------LLFH-------------GRYP-C------ 570
                 ::.|..:::.:.|..|               |||.             |.:| |
Yeast   901 GDIQFYLLDNMLLFLKAKAVNKWHQHKVFQRPIPLPLLFACPGEDMPALRKYIGDHPDCSGTVIQ 965

  Fly   571 -EHIGISAKTKSFTLYYERRKQQECEFTADPVQIAIWLDLIRDMINNYANEERQKLQERYSREND 634
             |:...:.|.....|||..:::.:....|                ..||.  .|.|.|:..:...
Yeast   966 PEYNTSNPKNAITFLYYGAKQRYQVTLYA----------------AQYAG--LQTLLEKIKQGQA 1012

  Fly   635 HLHRKAPSFSLYRDSNRF 652
            .:..|...|::.:.|:||
Yeast  1013 AIISKTEMFNVTKMSDRF 1030

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30456	NP_611188.3	RhoGEF	326..470	CDD:279015	40/203 (20%)
ROM2	NP_013475.1	ROM1	4..1356	CDD:227709	158/863 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	1	0.960