Protein Alignment CG46491 and plekhg4

DIOPT Version :10

• Sequence 1: NP_611188.3
• Gene: CG46491 / 36929
• FlyBaseID: FBgn0287631
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_001128280.3
• Gene: plekhg4 / 779571
• XenbaseID: XB-GENE-5998210
• Length: 1921
• Species: Xenopus tropicalis
• Alignment Length: 706
• Identity: 157/706 - (22%)
• Similarity: 286/706 - (40%)
• Gaps: 159/706 - (22%)

  Fly    28 RRRISHQAAEQERHSSTLVSSNLESNDVARPVSSVSSSSSSIQLSYS--------VNSDTDSSYR 84
            |.:|.|....:|:.        :|..::|..: .:..::...:.::|        :....:::.|
 Frog  1139 RYKIQHPEISEEKF--------MEMKELACEL-KIEKATKQWKFAWSKCQEARHVLEKKLEAALR 1194

  Fly    85 HRSLLKMHEAESVGGLGTESTPESPMSPQTPDPALLDVRQKVHRFEAFRTNICFIKQERHSLKLL 149
            .:|:|.          |.:|:|......:..:  ||:..:..:.|::...|.....:||...::|
 Frog  1195 AKSMLS----------GEQSSPREADGMEQKE--LLESNRNKYFFQSKPYNSPLCPRERRLGRVL 1247

  Fly   150 ENRRHPSFEDQSEDHHTPPATPPRRIRLPGLGSRGSSRSSSIPSFQAGIHEVRSEDEVDQISDFE 214
            .||  |.. ..::||.|..|:|        ....||:.:|...:.:..:..:..||
 Frog  1248 CNR--PEI-GNTDDHTTRKASP--------TSDAGSTVTSVFRTRKMSLQSISGED--------- 1292

  Fly   215 TDSHTAAEEYLVVDTTSEVVPSEEVADSKVDQQQVQRSISADQSKEALTLPLKMRNDFP------ 273
                      |.:|.. .:.||.....:...:...:|.:...||   ..||   .::.|
 Frog  1293 ----------LSLDLL-HIAPSGSSTPTVTPRPFTRRLLRKAQS---FDLP---GSEGPGYGCQR 1340

  Fly   274 RNYRSTPRRKTEI----IGTTNEHLVGKFHSVYQPKDEEEEV----------EIELRDKSDKCVH 324
            |....|.|..|.:    :..::..||.:..|..|.:|...|.          ..:.|.:|.|..|
 Frog  1341 RLSEPTRRGNTGVFIKGLEVSSTELVDRPCSPRQTRDWSAECMYSERRCSVSSSDGRSRSSKLRH 1405

  Fly   325 PILEELIKTEEAYVNNLFTGIENYGNIFQRKDLPLGLRGKKYDLFGNIEQIAEFHRDEFLPMLQR 389
             |::|::.||..||.:|:...|||....:|.|||..||||:..:|||:|::.:||...||..|:.
 Frog  1406 -IIDEMVTTEREYVRSLWYISENYFPEMERVDLPQDLRGKRGIIFGNLEKLRDFHSQYFLKELES 1469

  Fly   390 NRRDLKRLFDEFLQFLDQHCFYGYVIFTMNKQKSLKLCDLYKN-YFTSIRLERDDKLGINSFLVQ 453
            ......|:...||:..||  |..|.:::.||.:|..|...:.| :|.:.:....||:.:.|:|::
 Frog  1470 CCNHPLRVSHCFLRHKDQ--FGMYALYSKNKPRSDALLGSHGNIFFKNKQFLLGDKMDLASYLLK 1532

  Fly   454 PIQRMARYPLLLTQFINTFFKNRDIVMKPLIESCCRLEKRLRALLTTTNESEII-----NDIV-- 511
            |||||::|.|||               |.||:.|...:::..|.|....|....     ||::
 Frog  1533 PIQRMSKYALLL---------------KDLIKECEEAQEQELAYLRAAEEMVKFQLRHGNDLLAM 1582

  Fly   512 ----DCHEFNVYYQGKFRKVNEFQV-LDHKLKRSYRSKVFIFDKCIIYTEIK----GKNLLFHGR 567
                || :.|:..||:..:.:||.| |..|   ..:..||:|:..|::::.|    |.::..:.|
 Frog  1583 DAIRDC-DVNLKEQGQLVRQDEFTVWLGRK---KCQRHVFLFEDLILFSKPKRIEGGLDVYIYKR 1643

  Fly   568 -YPCEHIGISAKTKS----FTLYYERRKQQECEF--TADPVQIAIWLDLIRDMINNYANEERQ-K 624
             :....||::..:..    |.:::.|||..:...  .::|.....|...|..::...|...:: :
 Frog  1644 SFKTADIGLTENSGDSGLRFEIWFRRRKSSDTHILQASNPETKHAWTSDIAKILWQQATRNKEIR 1708

  Fly   625 LQERYSRENDHLHRKAPSFSLYRDSNRFSSDSGIGN-IWIMPKADEDTISNRTTWY 679
            :||..|                         .|:|| .::..|..:..|:||...|
 Frog  1709 MQEMVS-------------------------MGVGNKPFLDIKPSDAAINNRAVDY 1739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG46491	NP_611188.3	RhoGEF	326..469	CDD:459876	53/143 (37%)
		ROM1	<438..>660	CDD:227709	53/245 (22%)
plekhg4	NP_001128280.3	SEC14	726..857	CDD:469559
		SPEC	989..1193	CDD:413338	7/62 (11%)
		RhoGEF	1406..1568	CDD:459876	59/178 (33%)
		PH_puratrophin-1	1570..1705	CDD:270062	29/138 (21%)