Protein Alignment CG46491 and VAV2

DIOPT Version :10

• Sequence 1: NP_611188.3
• Gene: CG46491 / 36929
• FlyBaseID: FBgn0287631
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: XP_047279801.1
• Gene: VAV2 / 7410
• HGNCID: 12658
• Length: 919
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 113/543 - (20%)
• Similarity: 180/543 - (33%)
• Gaps: 182/543 - (33%)

  Fly   174 RIRLPGLGSRGSSRSSSIPSFQA-------------GIHEVRSEDEVDQISDFETDSHTAAEEYL 225
            :|.:.|||.|.....|.:....|             ||....||:..:...|........|:|:.
Human   169 QICVSGLGQRDGPFLSPVMVISAVSRLSLHSIAQNKGIRPFPSEETTENDDDVYRSLEELADEHD 233

  Fly   226 VVDTTSEVVPSEEVADS------KVDQQQVQRSISADQSKEALTLPLKMRNDFPRNYRSTPRRKT 284
            :.:...:.||.|:..|.      ||:.||                |:||
Human   234 LGEDIYDCVPCEDGGDDIYEDIIKVEVQQ----------------PMKM---------------- 266

  Fly   285 EIIGTTNEHLVGKFHSVYQPKDEEEEVEIELRDKSDKCVHPILEELIKTEEAYVNNLFTGIENYG 349
               |.|.:                        ||.:.|    |.|:.:||..|...|....:||.
Human   267 ---GMTED------------------------DKRNCC----LLEIQETEAKYYRTLEDIEKNYM 300

  Fly   350 NIFQRKDLPLGLRGKKYDL---FGNIEQIAEFHRDEFLPMLQRNRRDL------KRLFDEFLQFL 405
            :       ||.|.....|:   |.|:|.:.:.|. .||..:     |:      ..|...||.|.
Human   301 S-------PLRLVLSPADMAAVFINLEDLIKVHH-SFLRAI-----DVSVMVGGSTLAKVFLDFK 352

  Fly   406 DQHCFYG-YVIFTMNKQKSLKLCDLYKNYFTSIRLE------RDDKLGINSFLVQPIQRMARYPL 463
            ::...|| |.....:.|.:|......:..|.. ::|      :|.|..:...||.|:||:.:|.|
Human   353 ERLLIYGEYCSHMEHAQNTLNQLLASREDFRQ-KVEECTLKVQDGKFKLQDLLVVPMQRVLKYHL 416

  Fly   464 LLTQFINTFFKNRDIVMKPLIESCCRLEKR--LRALLTTTNESEIINDIVDCHEFNVYYQGKFRK 526
            ||.:.::              .|..|.|::  ..||....:.:..||::....|       ..||
Human   417 LLKELLS--------------HSAERPERQQLKEALEAMQDLAMYINEVKRDKE-------TLRK 460

  Fly   527 VNEFQV----LDHKLKRSYRSKV-------------------FIFDKCIIYTEIKGKN------- 561
            ::|||.    |..||:...|.|:                   |:|||.:|..:.||.:
Human   461 ISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEII 525

  Fly   562 -LLFHGRY--PCEHIGISAKTKSFTLYYERRKQQECEFTADPVQIAIWLDLIRDMINNYANEERQ 623
             ||||...  |..:..:...:..|.|.:.:.||....|.........|::.....::|...::
Human   526 ELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDK-- 588

  Fly   624 KLQERYSRENDHLHRKAPSFSLY 646
                  :..|.|      ||.:|
Human   589 ------ANANHH------SFQMY 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG46491	NP_611188.3	RhoGEF	326..469	CDD:459876	41/158 (26%)
		ROM1	<438..>660	CDD:227709	54/250 (22%)
VAV2	XP_047279801.1	CH_SF	2..110	CDD:469584
		RhoGEF	277..450	CDD:214619	48/204 (24%)
		PH_Vav	464..586	CDD:269930	26/121 (21%)
		C1_VAV2	589..646	CDD:410418	5/17 (29%)
		SH3_VAV2_1	660..719	CDD:212913
		SH2_Vav2	737..839	CDD:198269
		SH3_VAV2_2	860..917	CDD:212910