Protein Alignment CG46491 and VAV1

DIOPT Version :10

• Sequence 1: NP_611188.3
• Gene: CG46491 / 36929
• FlyBaseID: FBgn0287631
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_005419.2
• Gene: VAV1 / 7409
• HGNCID: 12657
• Length: 845
• Species: Homo sapiens
• Alignment Length: 322
• Identity: 64/322 - (19%)
• Similarity: 117/322 - (36%)
• Gaps: 101/322 - (31%)

  Fly   291 NEHLVGKFHSVYQPKDEEEEVEI--ELRDKSDKCVHPILEELIKTEEAYVNNLFTGIENYGNIFQ 353
            ||...|  ..:|:.....|.|.:  ::.:...:|.  .|.|:.:|||.|.:.|       |:|.|
Human   165 NEEAEG--DEIYEDLMRSEPVSMPPKMTEYDKRCC--CLREIQQTEEKYTDTL-------GSIQQ 218

  Fly   354 RKDLPLGLRGKKYD---LFGNIEQIAEFHRDEFLPMLQRNRRDLK---------RLFDEFLQFLD 406
            ....||....|..|   :|.|||.:...| ..||       :::|         .|:..|:::.:
Human   219 HFLKPLQRFLKPQDIEIIFINIEDLLRVH-THFL-------KEMKEALGTPGAANLYQVFIKYKE 275

  Fly   407 QHCFYGYVIFTMNK---------------QKSLKLCDLYKNYFTSIRLERDDKLGINSFLVQPIQ 456
            :...||.....:..               |..|:.|....|         :.:..:...|:.|:|
Human   276 RFLVYGRYCSQVESASKHLDRVAAAREDVQMKLEECSQRAN---------NGRFTLRDLLMVPMQ 331

  Fly   457 RMARYPLLLTQFINTFFKNRDIVMKPLIESCCRLEKRLRALLTTTNE-SEIINDIVDCHEFNVYY 520
            |:.:|.|||.:.:    |:....|:         ::.||..|....: ::.:|::...:|
Human   332 RVLKYHLLLQELV----KHTQEAME---------KENLRLALDAMRDLAQCVNEVKRDNE----- 378

  Fly   521 QGKFRKVNEFQV----LDHKLKRSYRSKV-------------------FIFDKCIIYTEIKG 559
              ..|::..||:    ||..|....|.|:                   |:.||.::..:.:|
Human   379 --TLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRG 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG46491	NP_611188.3	RhoGEF	326..469	CDD:459876	38/169 (22%)
		ROM1	<438..>660	CDD:227709	27/146 (18%)
VAV1	NP_005419.2	CH_VAV1	2..121	CDD:409111
		RhoGEF	195..371	CDD:238091	44/214 (21%)
		PH_Vav	385..508	CDD:269930	11/54 (20%)
		C1_VAV1	510..566	CDD:410417
		SH3_VAV1_1	596..658	CDD:212912
		SH2_Vav1	665..767	CDD:198268
		SH3_VAV1_2	786..839	CDD:212909