DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG46491 and TIAM1

DIOPT Version :10

Sequence 1:NP_611188.3 Gene:CG46491 / 36929 FlyBaseID:FBgn0287631 Length:682 Species:Drosophila melanogaster
Sequence 2:NP_003244.2 Gene:TIAM1 / 7074 HGNCID:11805 Length:1591 Species:Homo sapiens


Alignment Length:568 Identity:123/568 - (21%)
Similarity:204/568 - (35%) Gaps:172/568 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 SSNLESNDVARPVSSVSSSS---SSIQLSYSVNSDTDSSYRHRSLLKMHEAESVGGLGTESTPES 108
            |.::|.:|.|......|.||   ..|:..| |||..::....:..||         .|.|     
Human   845 SIHIEKSDTAADTYGFSLSSVEEDGIRRLY-VNSVKETGLASKKGLK---------AGDE----- 894

  Fly   109 PMSPQTPDPALLDVRQKVHRFEAFRTNIC--FIKQERHSLKLLENRRHPSFEDQSEDHHTPPATP 171
                      :|::..:.  .:|..:::.  |:.|.  ||.||. |.:|..|:..|...:||.  
Human   895 ----------ILEINNRA--ADALNSSMLKDFLSQP--SLGLLV-RTYPELEEGVELLESPPH-- 942

  Fly   172 PRRIRLPGLGSRGSSRSSSIPSFQAGIHEVRSEDEVDQISDFETDSHTAAEEYLVVDTTSEVVPS 236
                |:.|....|.|..:.:.|...  |.:.||.        .:.:.||.||....|..|    |
Human   943 ----RVDGPADLGESPLAFLTSNPG--HSLCSEQ--------GSSAETAPEETEGPDLES----S 989

  Fly   237 EEVADSKVDQQQVQ---RSI----SADQSKEALTLPLKMRNDFPRNYRSTPRRKTEIIGTTNEHL 294
            :|...|....:||.   ||:    .:|||.                                   
Human   990 DETDHSSKSTEQVAAFCRSLHEMNPSDQSP----------------------------------- 1019

  Fly   295 VGKFHSVYQPKDEEEEVEIELRDKSD-KCVHPILEELIKTEEAYVNNLFTGIENYGNIFQRKDLP 358
                    .|:|........:|..|| ..:..::.||::||..||.:|...:|.|....|::.. 
Human  1020 --------SPQDSTGPQLATMRQLSDADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETF- 1075

  Fly   359 LGLRGKKYD-LFGNIEQIAEFHRDEFLPMLQRNRR---DLKRL--FDE-----------FLQFLD 406
              |...:.| ||||:.::.|| :.|||..|:...|   ||::|  .|:           ||.:.|
Human  1076 --LTQDELDVLFGNLTEMVEF-QVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYAD 1137

  Fly   407 QHCFYGYVIFTMNKQK------SLKLCDLYKNYFTSIRLERDDKLGINSFLVQPIQRMARYPLLL 465
            :  |..|..|..:..|      ..|....:|.:..:...::.....:.|:|::||||:.:|||||
Human  1138 R--FKLYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLL 1200

  Fly   466 TQFINTFFKNRDIVMKPLIESCCRLEKRLRALLTTTNE-SEIINDIVDCH-EFNVYYQ------- 521
            .:..            .|.::.......|...:.|.|: :..||::...| ||...:.       
Human  1201 RELF------------ALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQT 1253

  Fly   522 GKFRKVNEFQVLD---H-------------KLKRSYRSKVFIFDKCII 553
            |:.::|.:..:.|   |             |.|:......|:|...::
Human  1254 GEKKEVADLSMGDLLLHTTVIWLNPPASLGKWKKEPELAAFVFKTAVV 1301

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG46491NP_611188.3 RhoGEF 326..469 CDD:459876 47/165 (28%)
ROM1 <438..>660 CDD:227709 28/141 (20%)
TIAM1NP_003244.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..78
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 298..379
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 393..422
PH1_Tiam1_2 432..558 CDD:269937
Tiam_CC_Ex 572..669 CDD:408184
Ubl1_cv_Nsp3_N-like 766..832 CDD:475130
PDZ 858..>901 CDD:214570 13/67 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..1034 28/157 (18%)
RhoGEF 1044..1233 CDD:214619 52/206 (25%)
PH2_Tiam1_2 1235..1406 CDD:269957 11/67 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1456..1482
Blue background indicates that the domain is not in the aligned region.

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