Protein Alignment CG46491 and Plekhg1

DIOPT Version :10

• Sequence 1: NP_611188.3
• Gene: CG46491 / 36929
• FlyBaseID: FBgn0287631
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_001177928.1
• Gene: Plekhg1 / 679812
• RGDID: 1583676
• Length: 1380
• Species: Rattus norvegicus
• Alignment Length: 434
• Identity: 99/434 - (22%)
• Similarity: 184/434 - (42%)
• Gaps: 84/434 - (19%)

  Fly   257 QSKEALTLPLKMRNDFPRNYRSTPRRKTEIIGTTNEHLVGKFHSVYQPKDE-EEEVEIELRDKSD 320
            |.|||..:.|::....|  :.|:..:|....|..|...||:    .||:.. ..:.....:..:|
  Rat    45 QDKEAGAIKLELVPAQP--FSSSELQKDNPAGPPNMDGVGE----KQPRAPWRVDTNGTPQTTAD 103

  Fly   321 KCVHP-------ILEELIKTEEAYVNNLFTGIENY-GNIFQRKDLPLGLRGKKYDLFGNIEQIAE 377
            ....|       :::|:::||..||.:|.:.:|:| ..|..:..||||...:. .|||||:.|..
  Rat   104 SATSPKLLYVDRVVQEILETERTYVQDLKSIVEDYLACIRDQTKLPLGTEDRA-ALFGNIQDIYH 167

  Fly   378 FHRDEFLPMLQRNRRDLKRLFDEFLQFLDQHCFYGYVIFTMNKQKSLK-LCDLYKN-----YFTS 436
            |: .|.|..|:....|...:.:.|:...::  |:.|..:..|..:|:. |.:..:|     :|..
  Rat   168 FN-SELLQELENCENDPVAIAECFVSKSEE--FHIYTQYCTNYPRSVAVLTECMRNKMLAKFFRE 229

  Fly   437 IRLERDDKLGINSFLVQPIQRMARYPLLLTQFINTFFKNR---DIV----------------MKP 482
            .:......|.:.|:|::|:||:.:|.|||.:..|...|:.   |:|                ||.
  Rat   230 RQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKR 294

  Fly   483 LIESCCRLEKRLRALLTT------TNESEIINDIVDCHEFNVYYQGKFRKVNEFQVLDHKLKRSY 541
            ..|...||:: :::|||.      |:..|::            .:|.||           ::|:.
  Rat   295 KHEHAVRLQE-IQSLLTNWKGPDLTSYGELV------------LEGTFR-----------IQRAK 335

  Fly   542 RSK-VFIFDKCIIYTEIKGKNLLFHGRYPCEHI----GISAKTKSFTLY-YERRKQQECEFTADP 600
            ..: :|:.||.::.|:.:.....:.....|.::    .|..:..||::: |:..|.|........
  Rat   336 NERTLFLLDKLLLITKKREDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKSPKLQHTVQAKSQ 400

  Fly   601 VQIAIW-LDLIRDMINNYANEERQKLQERYSRENDHLHRKAPSF 643
            .:..:| |.|.|.::.|:|.:...|.::.. .|.|.:|.  |.|
  Rat   401 QEKRLWILHLKRLILENHAAKIPAKAKQAI-LEMDAIHH--PGF 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG46491	NP_611188.3	RhoGEF	326..469	CDD:459876	42/149 (28%)
		ROM1	<438..>660	CDD:227709	51/238 (21%)
Plekhg1	NP_001177928.1	RhoGEF	116..290	CDD:459876	46/177 (26%)
		PH_PLEKHG1_G2_G3	272..417	CDD:270063	31/168 (18%)