Protein Alignment CG46491 and PLEKHG2

DIOPT Version :10

• Sequence 1: NP_611188.3
• Gene: CG46491 / 36929
• FlyBaseID: FBgn0287631
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_073746.2
• Gene: PLEKHG2 / 64857
• HGNCID: 29515
• Length: 1386
• Species: Homo sapiens
• Alignment Length: 330
• Identity: 72/330 - (21%)
• Similarity: 134/330 - (40%)
• Gaps: 72/330 - (21%)

  Fly   326 ILEELIKTEEAYVNNLFTGIENY------GNIFQRKDLPLGLRGKKY-DLFGNIEQIAEFHRDEF 383
            :..|:::||.|||.:|.:.:|:|      |.:       |||..::. .||.|||.|.|| ..|.
Human   106 VAREIVETERAYVRDLRSIVEDYLGPLLDGGV-------LGLSVEQVGTLFANIEDIYEF-SSEL 162

  Fly   384 LPMLQRNRRDLKRLFDEFLQFLDQHCFYGYVIFTMNKQKSLKLC-DLYKNYFTSIRLERDD---- 443
            |..|: |......:.:.|:|..:.  |..|.::.||...||.|. :|..:...::.|:...
Human   163 LEDLE-NSSSAGGIAECFVQRSED--FDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLR 224

  Fly   444 -KLGINSFLVQPIQRMARYPLLLTQFINTFFKNRDIVMKPLIESCCRLEKRLRALLTTTNESEII 507
             .|.:.|||::|:||:.:|.|||.:....:.:......:.::|         .|:::.|..:..|
Human   225 HSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVE---------EAIVSMTAVAWYI 280

  Fly   508 NDIVDCHEFNVYYQGKFRKVNEFQ----------VLDHKLK---------RSYRSKVFIFDKCII 553
            ||:....|.....|...|::..:.          ||:...:         |.....:|:|.:.::
Human   281 NDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRMLL 345

  Fly   554 YTEIKGKNLLFHGRYPCEHIGISA--------KTKSFTLYYERR----KQQECEFTADPVQIAIW 606
            ..:.:|....:.|...|.::.:|.        |....|:...|.    |.||        :..:|
Human   346 VAKRRGLEYTYKGHIFCCNLSVSESPRDPLGFKVSDLTIPKHRHLLQAKNQE--------EKRLW 402

  Fly   607 LDLIR 611
            :..::
Human   403 IHCLQ 407

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG46491	NP_611188.3	RhoGEF	326..469	CDD:459876	47/155 (30%)
		ROM1	<438..>660	CDD:227709	37/210 (18%)
PLEKHG2	NP_073746.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..82
		RhoGEF	106..281	CDD:459876	50/194 (26%)
		PH_PLEKHG1_G2_G3	263..413	CDD:270063	25/162 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	436..540
		PHA03247	<443..904	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	554..612
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	701..739
		Atrophin-1	769..>1153	CDD:460830
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	790..815
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	829..859
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1037..1099
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1162..1191
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1291..1333
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1367..1386