DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30456 and arhgef25b

DIOPT Version :9

Sequence 1:	NP_611188.3	Gene:	CG30456 / 36929	FlyBaseID:	FBgn0050456	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	XP_005166148.2	Gene:	arhgef25b / 569561	ZFINID:	ZDB-GENE-080225-17	Length:	625	Species:	Danio rerio

Alignment Length:	708	Identity:	147/708 - (20%)
Similarity:	273/708 - (38%)	Gaps:	172/708 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 ISHQAAEQERHSSTLVSSNLE--SNDVARPVSSVSSSSSSIQLSYSVNSDTDSSYRHRSLLKMHE 93
            :::|...||::...|:....:  |...|.|.:...|.:..::   .:..|.||
Zfish    27 LNNQQWIQEQNEGCLLLEEKQGCSKKGAGPENEKKSWNQRLE---RIPEDKDS------------ 76

  Fly    94 AESVGGLGTES-TPESPMSPQTPDPALLDVRQKVHR-FEAFRTNICFIKQERHSLKLLENRRHPS 156
             .::.||...| .|:.|.|.......|..:....|: |.:.|.::...:..:...:.|
Zfish    77 -YTLTGLSDVSLPPDDPPSASVSTDDLSPISPSNHQLFSSRRASVTSTRSIKAFKRWL------- 133

  Fly   157 FEDQSEDHHTPPATPPRRIRLPGLGSRGSSRSSSIPSFQAGIHEVRSEDEVDQISDFETDSHTAA 221
                        ::|.||:.|.|.....||:....|.                           .
Zfish   134 ------------SSPVRRLSLGGGNKSQSSKGIQSPE---------------------------G 159

  Fly   222 EEYLVVDTTSEVVPSEEVADSKVDQQQVQRS--------ISADQSKEALTLPLKMRNDFPRNYRS 278
            ..|:.:..:    |::.........|::.||        :|.:.|.::...|..:.:.|.|| :|
Zfish   160 STYMFLPLS----PAQSPLSPMEKSQKLTRSYRSLDCGELSRETSPDSPYYPRYLNDLFQRN-QS 219

  Fly   279 TPRRKTEIIGTTNEHLVGKFHSVYQPKDEEEEVEIELRDKSDKCVHPILEELIKTEEAYVNNLFT 343
            ...:.:.....|::.||.:..|:       |:.|...|...:|.:: :|.||::||:.||.:|..
Zfish   220 FDVQTSVSPSLTDKTLVEQSQSL-------EDNEQHRRTALEKSIY-VLTELVETEKLYVEDLGL 276

  Fly   344 GIENYGNIFQRKDLPLGLRGKKYDLFGNIEQIAEFHRDEFLPMLQR--NRRD-LKRLFDEFLQFL 405
            .:|.|....:...:|..|.||...:||||.||.::|:|.||..|::  :..| |.:||.:..:.|
Zfish   277 VVEGYMLTMRSVGVPEYLEGKDKIVFGNIHQIYDWHKDYFLGELEKCVSEPDLLAQLFIKHERRL 341

  Fly   406 DQHCFYGYVIFTMNKQKSLKLCDLY-KNYFTSIRLERDDKLGINSFLVQPIQRMARYPLLLTQFI 469
            :.     ||::..|..||..:...| :.||..:|.:...:|.:|..|::|:||:.:|.|||..|:
Zfish   342 NM-----YVVYCQNMPKSEHIVSEYIETYFEDLRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFL 401

  Fly   470 NTFFK----NRDIVMKPLIESCCRLEKRLRALLTTTNESEIINDIVDC-----HEFNVYYQGKFR 525
            ..:.|    ..|  ::..:|..|.:.||             .||:::.     .|..:..|||..
Zfish   402 KYYTKAGRQTED--LERAVEVMCFVPKR-------------CNDMMNVGRLQGFEGQLRAQGKLL 451

  Fly   526 KVNEFQVLDHK---LKRSYRSKVFIFDKCIIYTE------------------IKGKNLLFHGRY- 568
            :.:.|..::::   |.|....:||:|::.||.:|                  ||...|....|.
Zfish   452 QQDTFTFIENENSILSRPKERRVFLFEQLIILSEPMDRKRGFSLPGYVYKNSIKISCLSIEDRCP 516

  Fly   569 --PCEHI----GISAKTKSFTLYYERRKQQECEFTADPVQIAIWLDLIRDMI---NNYANEERQK 624
              ||..:    .|....:.|.|   |....|...:        |.:.|..|:   .|:.|..:..
Zfish   517 EDPCRLVLTSRNIDGSLQKFIL---RASSSEIRTS--------WANDIIQMLETQRNFLNALQSP 570

  Fly   625 LQERYSRENDHLHRKAPSFSLYRDSNRFSS-DSGIGNIWIMPKADEDTISNRTTWYAA 681
            ::  :.|      ::..|.||.:.....:| :||: ..:.....|..|:....:|:::
Zfish   571 IE--FQR------KEIKSLSLGKSMTASASLNSGL-RPYSSASIDRQTLPCLQSWHSS 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30456	NP_611188.3	RhoGEF	326..470	CDD:279015	50/147 (34%)
arhgef25b	XP_005166148.2	RhoGEF	258..429	CDD:238091	56/191 (29%)
arhgef25b	XP_005166148.2	PH-like	434..573	CDD:327399	29/151 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22826
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910