DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30456 and mcf2a

DIOPT Version :9

Sequence 1:	NP_611188.3	Gene:	CG30456 / 36929	FlyBaseID:	FBgn0050456	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	XP_021328504.1	Gene:	mcf2a / 557201	ZFINID:	ZDB-GENE-030616-52	Length:	1111	Species:	Danio rerio

Alignment Length:	808	Identity:	165/808 - (20%)
Similarity:	285/808 - (35%)	Gaps:	218/808 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 RRISHQAAEQERHSSTLVSSNLESNDVARPVSSVSSSSSSIQLSYSVNSDTDSSYRHRSLLKMHE 93
            ||:........|....|: ||||:          |.....:...:.:..|.|:..|..:.|...|
Zfish   249 RRLKDAIRSVMREGRQLL-SNLET----------SRKEGDVDTRWDITQDWDTMQRLLAQLTDME 302

  Fly    94 AESVGGLGTESTPESPMSPQTPDPALLDVRQ--KVHRFE-AFRTNICFIK----QER-------- 143
            ....|..               |...|.::|  ::.|:| :|:...|.::    |||
Zfish   303 IAFDGFF---------------DKHHLKLQQYLQLLRYEHSFQEMECSLEKLRAQERKISIIGES 352

  Fly   144 -----HSLKLLENRRHPSFEDQSE-------------DHHTPPATPPRRI-----RLPGLGSRGS 185
                 .|::.|:.....:.|:.|.             .||...|...:|.     :...|.|..|
Zfish   353 LNQTEQSVRELDGLDKRAQEEMSRAQVLILHGHQLAAGHHYAMALIIQRCNELRHQCDTLTSALS 417

  Fly   186 SRSSSIPSFQAGIHEVRSED-----------------------------EVDQISDFETDSHTAA 221
            ::.||:...|..:|.:....                             ::::..:......||.
Zfish   418 TKRSSLTQAQTLLHRLEEAQRWCDDGAYLLANQQVEKCQCKEGAQTALRDIEKFQEAAPPLLTAG 482

  Fly   222 EEYLVVDTTSEVVP---------------------SEEVADSKVDQQQVQ-------RSISADQS 258
            .:.|.::..|.:.|                     |.::...|:..:.::       |..:..:|
Zfish   483 ADVLFLEYESVLTPYLQSHIEKTFQKYSSVQALIQSRQICLKKMADKHIRPIQLVAPRPENPPRS 547

  Fly   259 KEALTLP-------LKMRNDFP----RNYRSTPR-RKTEIIGTTNEHLVGKFHSVYQPKDEEEEV 311
            |..|..|       ||...|.|    |..|.:|. ||.|:|           |. || :......
Zfish   548 KSPLFSPKHDFNSGLKFTFDLPLPGKRTSRKSPNSRKIEVI-----------HD-YQ-RSSSLPY 599

  Fly   312 EIELRDKSDKCVHPILEELIKTEEAYVNNLFTGIENY----GNIFQRKDLPLGLRGKKYDLFGNI 372
            .|:..|.||.....:::|||:||..||..|...:..|    .|......||..||.|:..||||:
Zfish   600 SIDGEDSSDLLKRHVMKELIETERIYVEELLAVLLGYRAEMDNPSLAPLLPTSLRNKRDVLFGNL 664

  Fly   373 EQIAEFHRDEFLPMLQRNRRDLKRLFDE-------FLQFLDQHCFYGYVIFTMNKQKSLKLCDLY 430
            ..|..||...||       :||:...:.       ||:..|.  |:.|..:..||.:|..|...:
Zfish   665 PDIYNFHSSVFL-------QDLESCLESPEAVGACFLERKDH--FHLYECYCQNKPRSESLWRQF 720

  Fly   431 KN--YFTSIRLERDDKLGINSFLVQPIQRMARYPLLLTQFINTFFKNRDIVMKPLIESCCRLEKR 493
            .:  :|...:.:.:.||.::|:|::||||:.:|.|||.:.:.            ....|.|:.:.
Zfish   721 SDCPFFQECQKKLEHKLALDSYLLKPIQRLTKYQLLLKELLK------------YSSGCERVSEL 773

  Fly   494 LRALLTTTNESEIINDIVDCHEFNVY-YQGKFRKV------NEFQV-LDHK-----LKRSYRSK- 544
            ..||....:..:.:||  ..|:..:. |:|....:      ..|.| :.||     :|...|.|
Zfish   774 QGALEAMLDLLKSVND--SMHQIAITGYEGDLSDLGRVLMQGSFSVWIGHKKGPTRVKEMARFKP 836

  Fly   545 ----VFIFDKCIIY---TEIKGKNLLFHGRYPCEH------IGIS----AKTKSFTLYYERRKQQ 592
                :|:.:..:::   .|..|:|......|..:|      :||:    ...|.|.::|..| ::
Zfish   837 MQRHLFLHEHALLFCKRREEHGENADKTPSYSFKHCLKMSAVGITENVKGDVKKFEIWYSGR-EE 900

  Fly   593 ECEFTADPVQIAI-WLDLIRDMINNYANEERQKLQERYSRENDHLHRKAPSFSLYRDSNRFSSDS 656
            .....|..|::.| ||:.||.::.|...:.:::|....:.......:.:|..|:.:......|..
Zfish   901 VYVIQAPTVEVKIAWLNEIRKILTNQQKQLKEELCLSTAVSEQMQMQISPPLSVSKQQRASVSSD 965

  Fly   657 GIGNIWIMPKA---DEDTISNRTTWYAA 681
            |..:....|.|   ......||.:|..|
Zfish   966 GTESGHSSPDAFSCSSQQQRNRRSWPGA 993

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30456	NP_611188.3	RhoGEF	326..470	CDD:279015	48/156 (31%)
mcf2a	XP_021328504.1	SEC14	46..191	CDD:214706
		SPEC	324..520	CDD:321951	28/195 (14%)
		RhoGEF	611..788	CDD:238091	52/197 (26%)
		PH_Dbs	795..926	CDD:269934	28/131 (21%)
		SH3_DBS	1030..1084	CDD:212791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910