Protein Alignment CG46491 and ARHGEF40

DIOPT Version :10

• Sequence 1: NP_611188.3
• Gene: CG46491 / 36929
• FlyBaseID: FBgn0287631
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: XP_011535239.1
• Gene: ARHGEF40 / 55701
• HGNCID: 25516
• Length: 1523
• Species: Homo sapiens
• Alignment Length: 728
• Identity: 151/728 - (20%)
• Similarity: 249/728 - (34%)
• Gaps: 182/728 - (25%)

  Fly     1 MADEDLSPLPFRRERNLSNRNFNKRNSRRRISHQAAEQERHSSTLVSSNLESNDVARPVSSVSSS 65
            |..:.||.|   :|..|..|.|:           |..|||.:....:..||.|..::.|..:..
Human   809 MPGDTLSAL---QETELRFRAFS-----------AEVQERLAQAREALALEENATSQKVLDIFE- 858

  Fly    66 SSSIQLSYSVNSDTDSSYR-HRSLLKMHEAESVG-------GLGTESTPESPMSPQTPDPALLDV 122
                |....|.|....:.| .|...:.||....|       |.|.|:...:....:.|:|:
Human   859 ----QRLEQVESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGREAVLAALALRRAPEPS---- 915

  Fly   123 RQKVHRFEAFRTNICFIKQERHSLKLLE-----NRRHPSFEDQSEDHHTPPATPP--RRIRLPGL 180
               ...|:..|.    :..:..|...|.     ..|....|.:.:.|....|:|.  ||.|..|.
Human   916 ---AGTFQEMRA----LALDLGSPAALREWGRCQARCQELERRIQQHVGEEASPRGYRRRRADGA 973

  Fly   181 GSRGSS---RSSSIPSFQAGIHEVRSEDEVDQISDFETDSHTAAEEYLVVDTTSEVVPSEEVADS 242
            .|.|:.   ||.| ||..:                            |::.::    |....|.|
Human   974 SSGGAQWGPRSPS-PSLSS----------------------------LLLPSS----PGPRPAPS 1005

  Fly   243 KVDQQQVQRSISADQSKEALTLPLKMRNDFPRN--YRSTPRRKTEIIGTT---NEH-LVGKFH-- 299
            ...    ......|..:|...|..:.....||.  .|......||::..|   .|| |:|:..
Human  1006 HCS----LAPCGEDYEEEGPELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRARGP 1066

  Fly   300 ----SVYQPKDEEEEVEIELRDKSDKCVHPILEELIKTEEAYVNNLFTGIENYGNIFQRKDLPLG 360
                .|..|:.|        |.:|......::.|||..|:.||..|...:...|     .:|...
Human  1067 DGPWGVGTPRME--------RKRSISAQQRLVSELIACEQDYVATLSEPVPPPG-----PELTPE 1118

  Fly   361 LRGKKYDLFGNIEQIAEFHRDEFLPMLQRNRRDLKRLFDEFLQFLDQHCFYGYVIFTMNKQKS-- 423
            |||.........|::..|||..||..||.......|:...||:..||...|...:...:|.::
Human  1119 LRGTWAAALSARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGL 1183

  Fly   424 LKLCDLYKNYFTSIRLERDDKLGINSFLVQPIQRMARYPLLLTQFINTFFKNRDIVMKPLIESCC 488
            ..|..|.|.     .:|....|  ...|.||::::.||..||.:.:..        ..|.:.|.|
Human  1184 AALSPLSKG-----SMEAGPYL--PRALQQPLEQLTRYGRLLEELLRE--------AGPELSSEC 1233

  Fly   489 RLEKRLRALLTTTNESE-------IINDIVDCHEFNVYYQGKFRKVNEFQVLDHKLKRSYRSKVF 546
            |   .|.|.:....|.|       .:..:..| |.::..||:....:.|.|:..: |:..| .||
Human  1234 R---ALGAAVQLLREQEARGRDLLAVEAVRGC-EIDLKEQGQLLHRDPFTVICGR-KKCLR-HVF 1292

  Fly   547 IFDKCIIYTEIKG-----KNLLFHGRYPCEHIGISAKTKS----FTLYYERRKQQEC---EFTAD 599
            :|:..::::::||     :..::...:....:|::.....    |.|::.||:.:|.   :.|:.
Human  1293 LFEHLLLFSKLKGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSP 1357

  Fly   600 PVQIAIWLDLIRDMI-NNYANEERQKLQERYSRENDHLHRKAPSFSLYRDSNRFSSDSGIGNIWI 663
            .:::. |...|..:: ...|:.:..::|:..|                         .||||
Human  1358 EIKLK-WTSSIAQLLWRQAAHNKELRVQQMVS-------------------------MGIGN--- 1393

  Fly   664 MPKADEDTISNRT 676
            .|..|...:..||
Human  1394 KPFLDIKALGERT 1406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG46491	NP_611188.3	RhoGEF	326..469	CDD:459876	39/144 (27%)
		ROM1	<438..>660	CDD:227709	44/241 (18%)
ARHGEF40	XP_011535239.1	SPEC	786..964	CDD:413338	38/184 (21%)
		RhoGEF	1090..1245	CDD:459876	45/177 (25%)
		PH_puratrophin-1	1244..1379	CDD:270062	25/138 (18%)