Protein Alignment CG46491 and Kalrn

DIOPT Version :10

• Sequence 1: NP_611188.3
• Gene: CG46491 / 36929
• FlyBaseID: FBgn0287631
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: XP_011244253.1
• Gene: Kalrn / 545156
• MGIID: 2685385
• Length: 2999
• Species: Mus musculus
• Alignment Length: 700
• Identity: 156/700 - (22%)
• Similarity: 265/700 - (37%)
• Gaps: 195/700 - (27%)

  Fly    30 RISHQAAEQERHSSTLVSSNLESNDVARPVSSVSSSSSSIQLSYSVNSDTDSSYRHRSLLKMHEA 94
            |.|....|.::     :|...|...|.:..|:..||..|||:..:|.            |....:
Mouse  1641 RTSQNTVESDK-----LSGGCELTVVLQDFSAGHSSELSIQVGQTVE------------LLERPS 1688

  Fly    95 ESVGGLGTESTPESPMSPQ---TPDPALLDVRQKVHRFEAFRTNICFIKQERHSLK------LLE 150
            |..|.....:|..||  ||   .|..||                 | |...|.|::      |.:
Mouse  1689 ERPGWCLVRTTERSP--PQEGLVPSSAL-----------------C-ISHSRSSVEMDCFFPLKD 1733

  Fly   151 NRRHPSFED----QSEDH----------HTPP-------------ATPPRRIRLPGLGS------ 182
            :..|.|.|:    :|..|          |:.|             .:|.||:. .|...
Mouse  1734 SYSHSSSENGGKSESVAHLQSQPSLNSIHSSPGPKRSTNTLKKWLTSPVRRLN-SGKADGNIKKQ 1797

  Fly   183 ---RGSSRSSSIPSFQAGIHEVRSEDEVDQIS-------DFETDSHTAAEEYLVVDTTSEVVPSE 237
               |...:|..:.|.:.|.......|..|:.|       :.:.:|||            .:.|..
Mouse  1798 KKVRDGRKSFDLGSPKPGDETTPQGDSADEKSKKGWGEDEPDEESHT------------PLPPPM 1850

  Fly   238 EVADSKVDQQQVQRSISADQS------------------KEALTLPLKMRNDFPRNYRSTPRRKT 284
            ::.|:...|.::...::|.|:                  |..|||.       ..:||.:.:..|
Mouse  1851 KIFDNDPTQDEMSSLLAARQAPPDVPTAADLVSAIEKLVKNKLTLE-------GGSYRGSLKDPT 1908

  Fly   285 EIIGTTNEHLVGKFHSVYQPKDEEEEVEIELRDKSDKCVHPILEELIKTEEAYVNNLFTGIENYG 349
               |..||.:.        |......:|.|.:.|:.:....:|.||::||:.||.:|...:|.:.
Mouse  1909 ---GCLNEGMT--------PPTPPRNLEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFM 1962

  Fly   350 NIFQRKDLPLGLRGKKYDLFGNIEQIAEFHRDEFLPMLQRNRRDLKRLFDEFLQFLDQHCFYGYV 414
            ...:.|.:|..:|||:..:||||.||.::|:|.||..|::..::..||...|::  .:...:.||
Mouse  1963 KRIEEKGVPEDMRGKEKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIK--HERKLHIYV 2025

  Fly   415 IFTMNKQKSLKLCDLYKNYFTSIRLERDDKLGINSFLVQPIQRMARYPLLLTQFINTFFKN---- 475
            .:..||.:|..:...|..||..::.|.:.:|.::.||::||||:.:|.|||..|:....|.
Mouse  2026 WYCQNKPRSEYIVAEYDAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLEC 2090

  Fly   476 RDIVMKPLIESCCRLEKRLRALLTTTNESEIINDIVDC-----HEFNVYYQGKFRKVNEFQVLDH 535
            .||  :..:|..|.:.||             .||:::.     .|..:..|||..:.:.|.|::.
Mouse  2091 SDI--EKAVELMCLVPKR-------------CNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIEL 2140

  Fly   536 KLKRSYRSK---VFIFDKCIIYTEIKGKNLLFHG---------RY----------PCEHIGISAK 578
            ......|:|   ||:|::.:|::|:..|..|..|         .|          ||:...::.:
Mouse  2141 DAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEDNVDGDPCKFALMNRE 2205

  Fly   579 TKSFTLYYERRKQQECEFTADPVQIAIWLDLIRDMIN------NYANEER 622
            |....:........:..:..|..|:   |:..||.:|      .|..:||
Mouse  2206 TSERVILQAANSDIQQAWVQDINQV---LETQRDFLNALQSPIEYQRKER 2252

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG46491	NP_611188.3	RhoGEF	326..469	CDD:459876	48/142 (34%)
		ROM1	<438..>660	CDD:227709	50/221 (23%)
Kalrn	XP_011244253.1	PH1_Kalirin_Trio_like	1469..1591	CDD:270060
		SH3_Kalirin_1	1657..1716	CDD:212786	21/90 (23%)
		SH3-RhoG_link	1714..1896	CDD:465196	35/212 (17%)
		RhoGEF	1939..2108	CDD:459876	56/185 (30%)
		PH2_Kalirin_Trio_p63RhoGEF	2113..2247	CDD:270061	26/136 (19%)
		SH3_Kalirin_2	2331..2387	CDD:212787
		I-set	2478..2572	CDD:400151
		Ig strand B	2495..2499	CDD:409353
		Ig strand C	2508..2512	CDD:409353
		Ig strand E	2538..2542	CDD:409353
		Ig strand F	2552..2557	CDD:409353
		Ig strand G	2565..2568	CDD:409353
		FN3	2576..2667	CDD:238020
		STKc_Kalirin_C	2697..2944	CDD:271017
		SEC14	47..185	CDD:214706
		SPEC	198..418	CDD:238103
		SPEC	319..544	CDD:238103
		SPEC	545..774	CDD:238103
		SPEC	899..1137	CDD:238103
		SPEC	1143..1243	CDD:197544
		RhoGEF	1292..1462	CDD:238091