Protein Alignment CG46491 and ARHGEF4

DIOPT Version :10

• Sequence 1: NP_611188.3
• Gene: CG46491 / 36929
• FlyBaseID: FBgn0287631
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_001354422.1
• Gene: ARHGEF4 / 50649
• HGNCID: 684
• Length: 1876
• Species: Homo sapiens
• Alignment Length: 658
• Identity: 130/658 - (19%)
• Similarity: 224/658 - (34%)
• Gaps: 171/658 - (25%)

  Fly    74 SVNSDTDSSYR---HRSLLKMHEAESVGGLGTESTPESPMSPQTPDPALLDVRQKVHRFEAFRTN 135
            :|..:..|..|   |||.:      ||..|..|.|....:..|.      .|.:::|.....:..
Human  1232 TVRGEAPSQPRGIPHRSPV------SVDDLWLEKTQRKKLQKQA------HVERRLHIGAVHKDG 1284

  Fly   136 I-CFIK---QERHSLKLLENRRHP-------SFEDQSEDHHTPPATPPRRIRLPGLGSRGSSRSS 189
            : |:.|   ....||. |..|.||       .........|||....|
Human  1285 VKCWRKTIITSPESLN-LPRRSHPLSQSAPTGLNHMGWPEHTPGTAMP----------------- 1331

  Fly   190 SIPSFQAGIHEVRSEDEVDQISDFETDSHTAAEEYLVVDTTSE-VVPSEEVADSKVDQQQVQRSI 253
                 ...:......|||....|...|.|:::..|.......| :..:|.::|..|        :
Human  1332 -----DGALDTAVCADEVGSEEDLYDDLHSSSHHYSHPGGGGEQLAINELISDGSV--------V 1383

  Fly   254 SADQSKEALTLPLKMRNDFPRNYRSTPRRKTEIIGTTNEHL--------VGKFHSVY-------- 302
            .|:...:.:|:     :|....:::..  ..|::..||...        .|.|.:.:
Human  1384 CAEALWDHVTM-----DDQELGFKAGD--VIEVMDATNREWWWGRVADGEGWFPASFVRLRVNQD 1441

  Fly   303 QPKDEE---------EEVEIELRDKSDKCVHPILEELIKTEEAYVNNLFTGIENY-------GNI 351
            :|.|::         |:...|.:...|:....::.|::.||..|:.:|....|.|       .::
Human  1442 EPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADM 1506

  Fly   352 FQRKDLPLGLRGKKYDLFGNIEQIAEFHRDEFLPMLQRNRRDLKRLFDEFLQFLD-QHCFYGYVI 415
            |..:.|        ..:|||||.|....:.....:.||..|:...|.:....||: |..|..|..
Human  1507 FSEEQL--------RTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSE 1563

  Fly   416 FTMNKQKS------LKLCDLYKNYFTSIR-LERDDKLGINSFLVQPIQRMARYPLLLTQFIN-TF 472
            :..|...:      |.....|..:|.:.| |::...:.::.||:.|:|::.:|||.|.:.:. |.
Human  1564 YCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTH 1628

  Fly   473 FKNRDI--------VMKPLIESCCRLEKRLRALLTTTNESEIIND------IVDCHEFNVYYQGK 523
            .::||.        .||.:.:.....::||..:.........|.|      :|...|  :.|.|:
Human  1629 PQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSE--LIYSGE 1691

  Fly   524 FRKVNEFQVLDHKLKRSYRSKVFIFDKCIIYTEIKGKNLL------FHGRYPCE----------- 571
            ..:|.:.|.      :|.:...|:||..:||.:   |:||      :.||...:
Human  1692 LTRVTQPQA------KSQQRMFFLFDHQLIYCK---KDLLRRDVLYYKGRLDMDGLEVVDLEDGK 1747

  Fly   572 ----HIGISAKTKSFTLYYERRKQQECEFTADPVQIAIWLDLIRDMINNYANEERQ-KLQERYSR 631
                |:.|.   .:|.|:...........|..|.|...||       ..:|.|..| :|.:....
Human  1748 DRDLHVSIK---NAFRLHRGATGDSHLLCTRKPEQKQRWL-------KAFAREREQVQLDQETGF 1802

  Fly   632 ENDHLHRK 639
            ....|.||
Human  1803 SITELQRK 1810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG46491	NP_611188.3	RhoGEF	326..469	CDD:459876	38/157 (24%)
		ROM1	<438..>660	CDD:227709	52/240 (22%)
ARHGEF4	NP_001354422.1	PRK07003	<617..>871	CDD:235906
		PHA03307	658..>1103	CDD:223039
		SH3_ASEF	1366..1438	CDD:212906	12/86 (14%)
		RhoGEF	1474..1653	CDD:214619	43/186 (23%)
		PH_Collybistin_ASEF	1658..1797	CDD:269931	32/159 (20%)