Protein Alignment CG46491 and trio

DIOPT Version :10

• Sequence 1: NP_611188.3
• Gene: CG46491 / 36929
• FlyBaseID: FBgn0287631
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_651960.2
• Gene: trio / 43974
• FlyBaseID: FBgn0024277
• Length: 2263
• Species: Drosophila melanogaster
• Alignment Length: 767
• Identity: 169/767 - (22%)
• Similarity: 293/767 - (38%)
• Gaps: 227/767 - (29%)

  Fly    38 QERHSSTLVSSNLESNDVARPVSSVSSSSSSIQLSYSVNSD-------TDSSYRHRSLLKMHEAE 95
            :|||.  ||::::.....|..|.||   ..|::..|....|       :|.:.....|:..|:.:
  Fly   993 EERHK--LVTASINFYKTAEQVCSV---LDSLEREYKREDDWCDGGGGSDKAQAIVQLISKHQEQ 1052

  Fly    96 SVGGLGTESTPESPMSPQTPDPALLDVRQKVHRF--EAFRTNICF---------IKQERHSLKLL 149
            ....|                .|....|:....|  .|.|:..|:         :|.:...|...
  Fly  1053 KEAFL----------------KACTLARRTAETFLKYANRSQQCYQYKGNCEGHVKSKLDKLLTQ 1101

  Fly   150 ENR-------RHPS---------FEDQSED-----HHTPPATPPRRIRLPGLGSRGSSRSSSIPS 193
            ||:       |..|         ||..::.     |:|..|..             ||||:.:
  Fly  1102 ENQVLDYWTLRKKSLDQCQQFVLFERSAKQAIEWIHNTGEAYL-------------SSRSNLV-- 1151

  Fly   194 FQAGIHEVRSEDEVDQISDFETDSHTAAEEYLVVDTTSEVVPSEEVADSKVDQQQVQRS------ 252
               ||.:..:|..:.:.::|.:   ||.|      |...|....::|||.|::.....|
  Fly  1152 ---GISKEETEGLLKEHNEFRS---TAKE------TRERVKLLIQLADSLVEKGHAHASDIKQWV 1204

  Fly   253 ISADQSKEALTLPLKMRNDFPRNYRSTPRRKTEIIGTTNEHLV-------------GKFHS---- 300
            .|.||..:          ||.....|...:..:.:|.:.:.|:             |..||
  Fly  1205 ASVDQRYK----------DFSNRMDSYCEQLEKSLGMSQQQLLLGSDGNSSISSSSGDRHSDPTL 1259

  Fly   301 ---VYQPKDEEEEVEIELRDKSDKCVHPILEELIKTEEAYVNNLFTGIENYGNIFQR-KDLPLGL 361
               :.....|.:|:..|.| ||.:....|:.||::||.||||:|.|.|:.:...|:. |.:|..|
  Fly  1260 EAKLNSSNKENKEINEEKR-KSARRKEFIMAELMQTERAYVNDLATCIKCFLEEFRAGKSVPSAL 1323

  Fly   362 RGKKYDLFGNIEQIAEFHRDEFLPMLQRNRRDLKRLFDEFLQFLDQHCFYG-------YVIFTMN 419
            .|::..:||||::|..||:..||       |:|::.  |.:.....|||..       ||.:..|
  Fly  1324 IGQEDVIFGNIKEIHHFHQKIFL-------RELEKY--ETMPEDVGHCFVTWASKFDMYVHYCKN 1379

  Fly   420 KQKSLKLCDLY-KNYFTSI--RLERDDKLGINSFLVQPIQRMARYPLLLTQFINTFFKNRDIVMK 481
            |..|..|...: .::|..:  |||.|..|  .::|::|:||:.:|.|||          :|::
  Fly  1380 KPTSNNLLVQHGGSFFEELQRRLEVDHPL--PAYLIKPVQRITKYQLLL----------KDLL-- 1430

  Fly   482 PLIESCC-----RLEKRLRALLTT---TNESEIINDIVDCHEFNVYYQGKFRKVNEFQVLDHK-- 536
                |||     .:::.|..:|..   .|::..::.:.:| :.:|...|:....:.||..|.|
  Fly  1431 ----SCCEESHGEIKEGLEVMLNVPKKANDAMHLSLLENC-DVSVDKLGEVVLQDAFQAWDTKQI 1490

  Fly   537 LKRSYRSKVFIFDKCIIYT-EIKGKNLL---FHGRYPCEHIGISA-----KTKSFTLYYERRKQ- 591
            :::....:||:|:..:::. |:|..|::   |..:.....:||:.     :|| |.::..|...
  Fly  1491 IRKGRERRVFLFELYLLFAKEVKESNVVKYQFKSKLMTTDMGITEHIEGDETK-FAVWTGRSPML 1554

  Fly   592 QECEFTADPVQI---AIWLDLIRDMI-------------------NNYANEERQKLQERYSREND 634
            .:|........:   .||:..:|:::                   :..:....:.|.|:.: |||
  Fly  1555 SDCRIVLKATSLETKQIWVKKLREVMQETCFSGTSLTLPKSPAKHSGSSQRSSRDLDEQLT-END 1618

  Fly   635 HLHRKAPSFSLYRDSNRFSSDSGIGNIWIMPKADEDTISNRTTW----YAAT 682
            |......||.   ..|...||:.:||             ...||    |.||
  Fly  1619 HDRCSLASFG---SGNTTDSDNKLGN-------------QEATWVVADYIAT 1654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG46491	NP_611188.3	RhoGEF	326..469	CDD:459876	52/153 (34%)
		ROM1	<438..>660	CDD:227709	55/263 (21%)
trio	NP_651960.2	SEC14	13..152	CDD:214706
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103
		SPEC	782..997	CDD:238103	2/3 (67%)
		SPEC	897..1119	CDD:238103	28/146 (19%)
		SPEC	1125..1226	CDD:197544	29/137 (21%)
		RhoGEF	1287..1455	CDD:459876	58/194 (30%)
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060	24/123 (20%)
		SH3_Kalirin_1	1643..1707	CDD:212786	5/12 (42%)
		RhoGEF	1945..2121	CDD:459876
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061