Protein Alignment CG46491 and sif

DIOPT Version :10

• Sequence 1: NP_611188.3
• Gene: CG46491 / 36929
• FlyBaseID: FBgn0287631
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_001261446.1
• Gene: sif / 43892
• FlyBaseID: FBgn0085447
• Length: 2734
• Species: Drosophila melanogaster
• Alignment Length: 592
• Identity: 119/592 - (20%)
• Similarity: 209/592 - (35%)
• Gaps: 204/592 - (34%)

  Fly   139 IKQERHSLKLL--ENRRHP-------SFEDQSEDH---HTPPATPP-------RRIRLPGLGSRG 184
            :.||..||.::  .:|..|       ...|...|.   ..||..||       ..:.:|..|..|
  Fly  1296 VLQEEQSLSMMMRSSRTEPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMSEEMITGLIVPAPGWNG 1360

  Fly   185 SSRSSSIPSFQAGIHEVRSEDEVDQISDFETDSHTAAEEYLVVDTTSEVV--------PSEEVAD 241
            :|:....|           |.|....:.|...:..||:  |.|.....||        |:...:.
  Fly  1361 TSKDLYSP-----------EAESSPATSFVDPAAMAAQ--LAVGGVGGVVVGGLGVAKPTSRTSS 1412

  Fly   242 SKVD------QQQVQR-----SISADQSKEALTLPLKMRNDFPRNYRSTPRRKTEIIGTTNEHLV 295
            .:::      :|:.::     |:::..|..||                ||.|
  Fly  1413 FEIENLLKTAEQETRKSSPTGSVTSSVSTTAL----------------TPSR------------- 1448

  Fly   296 GKFHSVYQPKDEEEEVEIELRDKSDKCVHPILEELIKTEEAYVNNLFTGIENYGNIFQRKDLPLG 360
                   |..|.|:             :..::.||:.||..||.:|...:|:|....:|:..
  Fly  1449 -------QLTDAEK-------------LRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETF--- 1490

  Fly   361 LRGKKYD-LFGNIEQIAEFHRDEFLPMLQRNRRDLKRLFDEFLQFLDQHC--------------- 409
            |...:.: |||||.:|..|.| :||..|:.: .||:..|::|     :||
  Fly  1491 LSNAEINALFGNIHEIVTFQR-QFLQNLEES-LDLEPDFNKF-----EHCGQFRNVLFAIGSAFL 1548

  Fly   410 -----FYGYVIFTMNKQKSLKLCDLYKN--------YFTSIRLERDDKLGINSFLVQPIQRMARY 461
                 |..|..|..:..|:.|:  |:.|        :..:...::.....:.|:|::||||:.:|
  Fly  1549 YYVNHFKLYSSFCASHSKAQKV--LHPNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKY 1611

  Fly   462 PLLLTQFINTFFKNRDIVMKPLIESCCRLEKRLRALLTTTNESEIIND----IVDCHEFN----- 517
            ||||.|..|......|..:     ..|...|.:..:....||.:.|::    |.| |.|.
  Fly  1612 PLLLQQMRNLTDTRADEHV-----HLCEALKGMEKVAEHINEMQRIHEEYGAIFD-HLFRQHQKS 1670

  Fly   518 ------------VYYQG-KFRKVNEFQVLDHKLKR--SYRSKVFIFDKCIIY---TEIKGKNLLF 564
                        :||.| ::..:::|.   .|:|:  ...:..|:|...:::   ..::.|..|
  Fly  1671 CKQPIDLSPGDLLYYGGVEWLNISDFL---GKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKL- 1731

  Fly   565 HGRYPCEHIGISAKTKSFTLYYERRKQQECEFTADPV-----QIAIWLDLIRDMINNYANE---E 621
                    :|:|:|..:          .|.|.....|     ::.:.....:||.:::..|   .
  Fly  1732 --------MGVSSKNAT----------NEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHL 1778

  Fly   622 RQKLQER 628
            |.:||.|
  Fly  1779 RSQLQRR 1785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG46491	NP_611188.3	RhoGEF	326..469	CDD:459876	47/171 (27%)
		ROM1	<438..>660	CDD:227709	46/226 (20%)
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		Tiam_CC_Ex	999..1096	CDD:408184
		RBD	1141..1207	CDD:128731
		PDZ	1220..1299	CDD:214570	0/2 (0%)
		RhoGEF	1456..1647	CDD:238091	51/207 (25%)
		PH2_Tiam1_2	1650..1823	CDD:269957	28/159 (18%)
		PHA03307	2227..>2510	CDD:223039