Protein Alignment CG46491 and Arhgef40

DIOPT Version :10

• Sequence 1: NP_611188.3
• Gene: CG46491 / 36929
• FlyBaseID: FBgn0287631
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: XP_038949404.1
• Gene: Arhgef40 / 361034
• RGDID: 1308093
• Length: 1520
• Species: Rattus norvegicus
• Alignment Length: 750
• Identity: 152/750 - (20%)
• Similarity: 257/750 - (34%)
• Gaps: 205/750 - (27%)

  Fly    17 LSNRNFNKRNSRRRISHQAAE---------QERHSSTLVSSNLESNDVARPVSSVSSSSSSIQLS 72
            |||....::..|:|: .|..|         :|:.:|..:..|                      |
  Rat   769 LSNLRVQQQEQRQRL-RQVQEVLQWLSGPGEEQLASFTIPGN----------------------S 810

  Fly    73 YSVNSDTDSSYR------HRSLLKMHEAESVGGLGTESTPESPMSPQTPDPALLDVRQKVHRFEA 131
            .||..:|:..:|      ...|::..||     |..|....|.......:..|..|...:||  |
  Rat   811 LSVLQETELRFRAFSTEVQERLVQAREA-----LALEEDITSQKVLDIFEQRLEQVESGLHR--A 868

  Fly   132 FRTNICFIKQERHS-------------------LKLLENRRHP-----SFEDQ---SEDHHTPPA 169
            .|....|  |:.|.                   |..|..||.|     :|::.   :.|..:|.|
  Rat   869 LRLQRFF--QQAHEWVDEGCARLAGAGPGREAVLAALALRRAPEPSAGTFQEMRALALDLGSPAA 931

  Fly   170 TP------------PRRIRLPGLGSRGSSRSSSIPSFQAGIHEVRSEDEVDQISDFETDSHTAAE 222
            ..            .|||: ..||...|.||          |..|..|.... :..:..:|:.:.
  Rat   932 LREWGRCRARCQELERRIQ-QQLGEEASPRS----------HRRRRADSASS-AGAQHGAHSPSP 984

  Fly   223 EYLVVDTTSEVVPSE---EVADSKVDQQQVQRSISADQSKEALTLPLKMRNDFPRN--YRSTPRR 282
                 ..:|.::||.   ..|.|...    ......|..:|.|.|..:.....||.  .|.....
  Rat   985 -----SLSSLLLPSSPGPRAAPSHCS----LTPCGEDYEEEGLELAPEADGRPPRAVLIRGLEVT 1040

  Fly   283 KTEIIGTT---NEH-LVGKF------HSVYQPKDEEEEVEIELRDKSDKCVHPILEELIKTEEAY 337
            .||::..|   .|| |:|:.      ..:..|:.|        |.:|......::.|||..|:.|
  Rat  1041 STEVVDRTCSPREHVLLGRAGGPDGPWGIGTPRME--------RKRSISAQQRLVSELIDCEQEY 1097

  Fly   338 VNNLFTGIENYGNIFQRKDLPLGLRGKKYDLFGNIEQIAEFHRDEFLPMLQRNRRDLKRLFDEFL 402
            :..|...:...|     .:|..|||..........|::..||...||..||.......|:...||
  Rat  1098 ITTLNEPVPPPG-----PELTPGLRCTWAAALSVRERLRSFHGTHFLQELQGCTAHPLRIGACFL 1157

  Fly   403 QFLDQHCFYGYVIFTMNKQKSLKLCDLYKNYFTSIRLERDDKLGINSFLVQPIQRMARYPLLLTQ 467
            :..||...|...:...:|.:| .|..|    ..|::...:....:...|.||::::|||..||.:
  Rat  1158 RHGDQFNLYAQFVKHRHKLES-GLTAL----TPSVKGSMEGSPCLPRALQQPLEQLARYAQLLEE 1217

  Fly   468 FINTFFKNRDIVMKPLIESCCRLEKR-LRALLTTTNESE-------IINDIVDCHEFNVYYQGKF 524
            .:..        ..|.:.|    |:: |||.:....|.|       .:..:..| |.::..||:.
  Rat  1218 LLRE--------AGPELSS----ERQALRAAVQLLQEQEARGRDLLAVEAVRGC-EIDLREQGQL 1269

  Fly   525 RKVNEFQVLDHKLKRSYRSKVFIFDKCIIYTEIKG-----KNLLFHGRYPCEHIGISAKTKS--- 581
            ...:.|.|:..: |:..| .||:|:..:::::.||     :..::...:....:|::.....
  Rat  1270 LHRDPFTVICGR-KKCLR-HVFLFEDLLLFSKSKGSEGGSETFVYKQAFKTADMGLTENIGDSGL 1332

  Fly   582 -FTLYYERRKQQEC---EFTADPVQIAIWLDLIRDMI-NNYANEERQKLQERYSRENDHLHRKAP 641
             |.|::.||:.:|.   :.|:...::. |...|..:: ...|:.:..::|:..|
  Rat  1333 CFELWFRRRRAREAYTLQATSPETKLK-WTSSIAQLLWRQAAHNKELRVQQMVS----------- 1385

  Fly   642 SFSLYRDSNRFSSDSGIGNIWIMPKADEDTISNRT 676
                          .||||   .|..|...:..||
  Rat  1386 --------------MGIGN---KPFLDIKALGERT 1403

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG46491	NP_611188.3	RhoGEF	326..469	CDD:459876	37/142 (26%)
		ROM1	<438..>660	CDD:227709	43/242 (18%)
Arhgef40	XP_038949404.1	PHA03247	<251..446	CDD:223021
		SPEC	789..967	CDD:413338	42/219 (19%)
		RhoGEF	1087..1242	CDD:459876	43/176 (24%)
		PH_puratrophin-1	1241..1376	CDD:270062	25/138 (18%)