Protein Alignment CG46491 and quob

DIOPT Version :10

• Sequence 1: NP_611188.3
• Gene: CG46491 / 36929
• FlyBaseID: FBgn0287631
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: XP_068077749.1
• Gene: quob / 321031
• ZFINID: ZDB-GENE-030131-9944
• Length: 1988
• Species: Danio rerio
• Alignment Length: 660
• Identity: 139/660 - (21%)
• Similarity: 265/660 - (40%)
• Gaps: 144/660 - (21%)

  Fly    33 HQAAEQERHSSTLVSSNLESNDVARPVSSVSSSSSSIQLSYSVN-SDTDSSYRHRSLLKMHEAES 96
            ::||||..:.:.....:.|.:...:.::|.....|:.::..||. ::.::.:.|.:..|:|.|.|
Zfish  1237 NRAAEQGDNETLTYLQSAEGSKFEQVMTSSVHEQSASRIQQSVECTEQETRHLHETKDKLHNASS 1301

  Fly    97 VGGLGTESTPESPMSPQTPDPALLDVRQKVHRFEAFRTNICFIKQERHSLKLLENRRHPSFEDQS 161
               :..|||..:..|.|                       |.:::.....:.....|:||....|
Zfish  1302 ---MHNESTSHAQQSVQ-----------------------CTVQKASMLQETNNTSRNPSMHKDS 1340

  Fly   162 EDH---------------HTPPATPPRRIRLPGLGSRGSSRSSSIPSFQAGIHE-VRSEDEVDQI 210
            ..|               |.|.|.               |...|....:...|: ..|:|::.:.
Zfish  1341 ASHIQESVQCTDQNTSHLHEPQAI---------------SHHPSDRKLKEHHHKHSHSDDDLRKS 1390

  Fly   211 SDFETDSHTAAEEYLVVDTTSEV--------VP--SEEVADSKVDQQQVQRSISADQSKEALTLP 265
            ........||..:..:...::|.        :|  ..:.|.|.|           ..|.|.|:..
Zfish  1391 GRIHKFGQTAHYKVFIRSQSAESCLRGYRYNIPLCKTDAAASCV-----------GASLEGLSSE 1444

  Fly   266 LKMRNDFPRNYRSTPRRKTEIIGTTNEHLVG----------KFHSVYQPKDEEEEVEIELRDKSD 320
            |...:.|..:.....::.:...| :.:|..|          :..||.:|:...|.....|:
Zfish  1445 LNQHDSFCSSASGFSQKCSSDCG-SEDHGSGVRCSDNAFTKQEESVCKPECILENTSTALK---- 1504

  Fly   321 KCVHPILEELIKTEEAYVNNLFTGIENYGNIFQRKDLPLGLRGKKYDLFGNIEQIAEFHRDEFLP 385
              :..|::||::||:.||..|...:|||....:|.|:|..|||::..:|||:|::.:||:..|:.
Zfish  1505 --LQRIMQELLQTEQEYVRALAYVVENYMPELERPDVPQDLRGQRGLIFGNLEKLRDFHQHHFIQ 1567

  Fly   386 MLQRNRRDLKRLFDEFLQFLDQHCFYG-YVIFTMNKQKSLKLCDLY-KNYFTSIRLERDDKLGIN 448
            .|:   ..|::.|.....||.....:| |.:::.||.:|..|...: |::|...:....|.|.::
Zfish  1568 ELE---LCLEKPFSVGRCFLKHKESFGLYALYSKNKPRSENLLIQHGKDFFKQKQQLLKDALDLS 1629

  Fly   449 SFLVQPIQRMARYPLLLTQFINTFFKNRDIVMKPLIESC-CRLEKRLR------AL------LTT 500
            |:|::|:||:::|.|||               :.|:..| |.....|:      ||      |..
Zfish  1630 SYLLKPVQRISKYSLLL---------------QDLLRECECVTNAELQRTEIHTALNIIQFQLRH 1679

  Fly   501 TNESEIINDIVDCHEFNVYYQGKFRKVNEFQVLDHKLKRSYRSKVFIFDKCIIY-----TEIKGK 560
            .|....::||..| :.|:..||:..:.:|| :|..:.|:.|| .:|:|...|::     |::...
Zfish  1680 GNNLLAMDDIYGC-DVNLKEQGQLIRQDEF-LLTFRKKKCYR-HIFLFQDLILFSKTRKTDVGND 1741

  Fly   561 NLLFHGRYPCEHIGISAKTKS----FTLYYERRKQQE---CEFTADPVQIAIWLDLIRDMINNYA 618
            ..::...:....||::..:..    |.:::.|||.|:   .:..:..|:.:...||.|.:.....
Zfish  1742 TYIYKQSFKTSDIGMTHNSGDSGLCFEIWFRRRKTQDTYVLQAASREVKESWTRDLERILWEQAI 1806

  Fly   619 NEERQKLQER 628
            :....::|||
Zfish  1807 HNREIRMQER 1816

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG46491	NP_611188.3	RhoGEF	326..469	CDD:459876	48/144 (33%)
		ROM1	<438..>660	CDD:227709	49/216 (23%)
quob	XP_068077749.1	RhoGEF	1508..1654	CDD:459876	49/163 (30%)
		PH_puratrophin-1	1674..1809	CDD:270062	29/137 (21%)