DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG46491 and Trio

DIOPT Version :10

Sequence 1:NP_611188.3 Gene:CG46491 / 36929 FlyBaseID:FBgn0287631 Length:682 Species:Drosophila melanogaster
Sequence 2:NP_001101128.3 Gene:Trio / 310192 RGDID:1308360 Length:3103 Species:Rattus norvegicus


Alignment Length:661 Identity:157/661 - (23%)
Similarity:251/661 - (37%) Gaps:175/661 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 ISHQAAEQE-----RHSSTLVSSNLESNDVARPVSSVSSSSSSIQLSYSVNSDTDSSYRHRSLLK 90
            |:|..:..|     .|..:|   ::.||| |.|.:||:|                        |:
  Rat  1718 IAHSRSSMEMEGIFNHKDSL---SVSSND-ASPPASVAS------------------------LQ 1754

  Fly    91 MHEAESVGGLGTESTPESPMSPQTPDPALLD-VRQKVHRFEAFRTNICFIKQERHSLKLLENRRH 154
            .|.      :|.:|:|    .|:.|...|.. :...|.|..:.       |.:.|:.||....:.
  Rat  1755 PHM------MGAQSSP----GPKRPGNTLRKWLTSPVRRLSSG-------KADGHAKKLAHKHKK 1802

  Fly   155 P----------SFEDQSEDHHTP-PATPPRRIRLPGLGSRGSSRSSSIPSFQAGIHEVRSEDEVD 208
            .          |.:|..:...|| ..|...|.|..||.|...|:|||......|  |...|:..|
  Rat  1803 SREVRKSADAGSQKDSDDSAATPQDETIEERGRNEGLSSGTLSKSSSSGMQSCG--EEEGEEGAD 1865

  Fly   209 -----------QISDFETDSH-TAAEEYLVVDTTSEVVPS--------EEVADSKVDQQQVQRSI 253
                       |.|..:.||. ..|...|:|..||...||        ||:..||:..:....|:
  Rat  1866 AVPLPPPMAIQQHSLLQPDSQDDKASSRLLVRPTSSETPSAAELVSAIEELVKSKMALEDRPSSL 1930

  Fly   254 SADQSKEALTLPLKMRNDFPRNYRSTPRRKTEIIGTTNEHLVGKFHSVYQPKDEEEEVEIELRDK 318
            ..||...                 |:|.     ...::..|:    |...|.||.|    |.:..
  Rat  1931 LVDQGDS-----------------SSPS-----FNPSDNSLL----SSSSPIDEME----ERKCS 1965

  Fly   319 SDKCVHPILEELIKTEEAYVNNLFTGIENYGNIFQRKDLPLGLRGKKYDLFGNIEQIAEFHRDEF 383
            |.|..|.:|:||::||..||.:|...:|.|..:.:...:|..::||...:||||.||.::|||.|
  Rat  1966 SLKRRHYVLQELVETERDYVRDLGCVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFF 2030

  Fly   384 LPMLQRNRRDLKRLFDEFLQFLDQHCFYGYVIFTMNKQKSLKLCDLY-KNYFTSIRLERDDKLGI 447
            |..|::...|.::|...|::  .:...:.|:::..||.||..:...| ..:|..::.....:|.:
  Rat  2031 LGELEKCLEDPEKLGSLFVK--HERRLHMYIVYCQNKPKSEHIVSEYIDTFFEDLKQRLGHRLQL 2093

  Fly   448 NSFLVQPIQRMARYPLLLTQFINTFFKNRDI---VMKPLIESCCRLEKRLRALLTTTNESEIIND 509
            ...|::|:||:.:|.|||..|:. :.|...:   .::..:|..|.:.||             .||
  Rat  2094 TDLLIKPVQRIMKYQLLLKDFLK-YSKKASLDTSELEKAVEVMCIVPKR-------------CND 2144

  Fly   510 IVDC-----HEFNVYYQGKFRKVNEFQVLDHK---LKRSYRSKVFIFDKCIIYTEIKGK------ 560
            :::.     .:..:..|||....:.|.|.|..   |.|....:||:|::.:|::|...|      
  Rat  2145 MMNVGRLQGFDGKIVAQGKLLLQDTFLVTDQDAGLLPRCKERRVFLFEQIVIFSEPLDKKKGFSM 2209

  Fly   561 -NLLFHGRYPCEHIGISAKTKSFTLYYERRKQQECEF-----TADPVQIAI-----------WLD 608
             ..||..         |.|.....| .|..:...|:|     |.|.|:..|           |:.
  Rat  2210 PGFLFKN---------SIKVSCLCL-EENVESDPCKFALTSRTGDAVETFILHSSSPSVRQTWIH 2264

  Fly   609 LIRDMINNYAN 619
            .|..::.|..|
  Rat  2265 EINQILENQRN 2275

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG46491NP_611188.3 RhoGEF 326..469 CDD:459876 44/143 (31%)
ROM1 <438..>660 CDD:227709 47/216 (22%)
TrioNP_001101128.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27
SEC14 69..204 CDD:214706
SPEC 227..445 CDD:238103
Spectrin 1 311..418
SPEC 341..566 CDD:238103
Spectrin 2 538..644
SPEC 567..783 CDD:238103
SPEC 787..1014 CDD:238103
Spectrin 3 878..984
SPEC 908..1137 CDD:238103
Spectrin 4 1109..1216
SPEC 1143..1243 CDD:197544
RhoGEF 1295..1465 CDD:238091
PH1_Kalirin_Trio_like 1472..1594 CDD:270060
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1601..1651
SH3_Kalirin_1 1659..1718 CDD:212786 157/661 (24%)
SH3-RhoG_link 1715..1972 CDD:465196 74/330 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1738..1907 51/212 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1927..1956 7/54 (13%)
RhoGEF 1970..2143 CDD:238091 51/188 (27%)
PH2_Kalirin_Trio_p63RhoGEF 2148..2286 CDD:270061 30/138 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2287..2556
SH3_Kalirin_2 2559..2617 CDD:212787
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2643..2667
I-set 2689..2780 CDD:400151
Ig strand B 2706..2710 CDD:409570
Ig strand C 2719..2730 CDD:409570
Ig strand E 2746..2750 CDD:409570
Ig strand F 2760..2765 CDD:409570
Ig strand G 2773..2776 CDD:409570
STKc_Trio_C 2792..3054 CDD:271015
Blue background indicates that the domain is not in the aligned region.

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