Protein Alignment CG46491 and Pura

DIOPT Version :10

• Sequence 1: NP_611188.3
• Gene: CG46491 / 36929
• FlyBaseID: FBgn0287631
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_996016.2
• Gene: Pura / 2768948
• FlyBaseID: FBgn0035802
• Length: 1904
• Species: Drosophila melanogaster
• Alignment Length: 671
• Identity: 169/671 - (25%)
• Similarity: 286/671 - (42%)
• Gaps: 114/671 - (16%)

  Fly    31 ISHQAAEQERHSSTLVSSNLESNDVARPVSSVSSSSSSIQLSYSVNSDTDSSYRHRSLLKMHEAE 95
            :.|.|..::.|::.|..|.| |.......|::...:..::|::   ...|::.|...||..|:.|
  Fly  1096 MKHLAKGRDLHAAALKVSVL-SESANNLKSALDQFAQKLELAH---ERYDAAGRLLHLLTQHQRE 1156

  Fly    96 SVGGLGTESTPESPMSPQTPDPALLDVRQKVHRFEAFRTNICFIKQERHSLKLLENRRHPSFEDQ 160
            :......:...|     |....:||:....|.|             :.|:|.:..:
  Fly  1157 NAAREELQRLAE-----QLGATSLLEKHWPVMR-------------KTHTLPVASS--------- 1194

  Fly   161 SEDHHTPPATPPRRIRLPGLGSRGSSRSSSIPSFQAG--------IHEVRSEDEVDQI------S 211
                 ||.|...:|:     ..|.||.|.|  ||:.|        ..|.|:.:::||:      .
  Fly  1195 -----TPAAAAGKRV-----SYRCSSASRS--SFEGGPSSSNCSCWRESRNLEDMDQMEEEEEEQ 1247

  Fly   212 DFETDSHTAAEEYLVVDTTSEVVPSE-EVADSKVDQQQVQRSISADQSKEALTLPLKMRNDFPRN 275
            |.:.|.....|:      .|::..|. .|.|:.....::.|..|.....|.....|.....|.|
  Fly  1248 DHDCDGGDGEEQ------QSKIADSGLGVCDNCERNPKLARICSCQSLNEKSHDELLEDECFDR- 1305

  Fly   276 YRSTPRRKTEIIGT---TNEHLVGKFHSVYQPKDEEEEVEIELRDKSDKCVHPILEELIKTEEAY 337
               ..:|..:|:.:   .|.||.....|:..||.||...   |..|..|.:..|:.|:|.||..|
  Fly  1306 ---PSKRYMDIMHSPMEANAHLQCHGSSLELPKLEELSC---LDPKIQKTLLLIMREMIGTERDY 1364

  Fly   338 VNNLFTGIENYGNIFQRKDLPLGLRGKKYDLFGNIEQIAEFHRDEFLPMLQRNRRDLKRLFDEFL 402
            |.:|:..||||.:...|:|:|..|||::..:|||||:|.|||...||..|:|..|:..::...||
  Fly  1365 VRSLYYVIENYIDELLREDIPQPLRGQRNVIFGNIEKIFEFHNSHFLGELERYERNPLKVGAAFL 1429

  Fly   403 QFLDQHCFYGYVIFTMNKQKSLKLCDLY-KNYFTSIRLERDDKLGINSFLVQPIQRMARYPLLLT 466
            :.  :..||.|.::..||.||..|...| .::|...:::..|||.:.|:|::|:|||.:|.|||.
  Fly  1430 EM--ESKFYLYALYNKNKPKSDTLLSEYGSSFFKPKQMQLQDKLDLASYLLKPVQRMGKYALLLQ 1492

  Fly   467 QFINTFFKNRDIVMKPL---IESCCRLEKRLRALLTTTNESEIINDIVDCHEFNVYYQGKFRKVN 528
            |.:..........::.:   :|...|.|:.::..|...|:...::.:.|| :.||..||:..:.|
  Fly  1493 QLVKACKGVEGAALQEIAADVEELQRAEEMVKFQLRHGNDLLAMDSLRDC-DVNVKEQGRLLRQN 1556

  Fly   529 EFQVLDHKLKRSYRSKVFIFDKCIIYTEIK----GKNL---LFHGRYPCEHIGISAKT----KSF 582
            ||.|...:..:....:||:|::.:::::.:    .|||   ::........||::|.|    ..|
  Fly  1557 EFLVWQGRGGKKTLRQVFLFEELVLFSKARRFPDHKNLDIYIYKNSIKTSDIGLTAHTGDSATKF 1621

  Fly   583 TLYYERRKQQECEFTADPVQIAIW-LDLIRDMINNYANEERQKLQERYSRENDHLHRKAPSFSL- 645
            .:::.:||..:           .| |..:.:.|.|...||..||..:.::.|..: |.|...|:
  Fly  1622 EIWFRKRKPDD-----------TWMLQCMSEDIKNAWTEEISKLLWKQAKRNREV-RLAEMSSMG 1674

  Fly   646 --------YRDSNRFSSDSGI 658
                    .|.||...||..|
  Fly  1675 IGSKPCLDIRPSNNQISDRSI 1695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG46491	NP_611188.3	RhoGEF	326..469	CDD:459876	58/143 (41%)
		ROM1	<438..>660	CDD:227709	60/245 (24%)
Pura	NP_996016.2	COG4913	<1020..>1167	CDD:443941	15/74 (20%)
		RhoGEF	1353..1524	CDD:459876	61/172 (35%)
		PH_puratrophin-1	1524..1663	CDD:270062	33/150 (22%)